Journal of Bone and Joint Infection
Journal of Bone and Joint Infection
JBJI
Articles | Volume 6, issue 7
Articles | Volume 6, issue 7
https://doi.org/10.5194/jbji-6-283-2021
© Author(s) 2021. This work is distributed under
the Creative Commons Attribution 4.0 License.
https://doi.org/10.5194/jbji-6-283-2021
© Author(s) 2021. This work is distributed under
the Creative Commons Attribution 4.0 License.
Articles | Volume 6, issue 7
Original full-length article
 | 
20 Jul 2021
Original full-length article |  | 20 Jul 2021

Ceramic composite with gentamicin decreases persistent infection and increases bone formation in a rat model of debrided osteomyelitis

Aleksey Dvorzhinskiy, Giorgio Perino, Robert Chojnowski, Marjolein C. H. van der Meulen, Mathias P. G. Bostrom, and Xu Yang

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Short summary
Osteomyelitis is an infection of bone and is often treated with surgical debridement. This results in a bone defect which requires the use of a void filler. This study evaluated the use of a gentamicin-impregnated ceramic void filler (CERAMENT G) and compared it to the same void filler without antibiotic (CERAMENT) and no void filler in a rat model of osteomyelitis. CERAMENT G was found to decrease the rate of persistent infection and grow more new bone than CERAMENT or an empty defect.
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