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Journal of Bone and Joint Infection An open-access journal of the European Bone and Joint Infection Society and the MusculoSkeletal Infection Society
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Osteomyelitis is an infection of bone and is often treated with surgical debridement. This results in a bone defect which requires the use of a void filler. This study evaluated the use of a gentamicin-impregnated ceramic void filler (CERAMENT G) and compared it to the same void filler without antibiotic (CERAMENT) and no void filler in a rat model of osteomyelitis. CERAMENT G was found to decrease the rate of persistent infection and grow more new bone than CERAMENT or an empty defect.
JBJI | Articles | Volume 6, issue 7
J. Bone Joint Infect., 6, 283–293, 2021
https://doi.org/10.5194/jbji-6-283-2021
J. Bone Joint Infect., 6, 283–293, 2021
https://doi.org/10.5194/jbji-6-283-2021

Original full-length article 20 Jul 2021

Original full-length article | 20 Jul 2021

Ceramic composite with gentamicin decreases persistent infection and increases bone formation in a rat model of debrided osteomyelitis

Aleksey Dvorzhinskiy et al.

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Short summary
Osteomyelitis is an infection of bone and is often treated with surgical debridement. This results in a bone defect which requires the use of a void filler. This study evaluated the use of a gentamicin-impregnated ceramic void filler (CERAMENT G) and compared it to the same void filler without antibiotic (CERAMENT) and no void filler in a rat model of osteomyelitis. CERAMENT G was found to decrease the rate of persistent infection and grow more new bone than CERAMENT or an empty defect.
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