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Journal of Bone and Joint Infection An open-access journal of the European Bone and Joint Infection Society and the MusculoSkeletal Infection Society
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Osteomyelitis is an infection of bone and is often treated with surgical debridement. This results in a bone defect which requires the use of a void filler. This study evaluated the use of a gentamicin-impregnated ceramic void filler (CERAMENT G) and compared it to the same void filler without antibiotic (CERAMENT) and no void filler in a rat model of osteomyelitis. CERAMENT G was found to decrease the rate of persistent infection and grow more new bone than CERAMENT or an empty defect.
JBJI | Articles | Volume 6, issue 7
J. Bone Joint Infect., 6, 283–293, 2021
https://doi.org/10.5194/jbji-6-283-2021
J. Bone Joint Infect., 6, 283–293, 2021
https://doi.org/10.5194/jbji-6-283-2021

Original full-length article 20 Jul 2021

Original full-length article | 20 Jul 2021

Ceramic composite with gentamicin decreases persistent infection and increases bone formation in a rat model of debrided osteomyelitis

Aleksey Dvorzhinskiy et al.

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Ceramic Composite with Gentamicin Decreases Persistent Infection and Increases Bone Formation in Rat Model of Debrided Osteomyelitis Aleksey Dvorzhinskiy, Giorgio Perino, Robert Chojnowski, Marjolein C. H. van der Meulen, Mathias P. G. Bostrom, and Xu Yang https://doi.org/10.5281/zenodo.4581061

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Short summary
Osteomyelitis is an infection of bone and is often treated with surgical debridement. This results in a bone defect which requires the use of a void filler. This study evaluated the use of a gentamicin-impregnated ceramic void filler (CERAMENT G) and compared it to the same void filler without antibiotic (CERAMENT) and no void filler in a rat model of osteomyelitis. CERAMENT G was found to decrease the rate of persistent infection and grow more new bone than CERAMENT or an empty defect.
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