Ceramic composite with gentamicin decreases persistent infection and increases bone formation in a rat model of debrided osteomyelitis

Dvorzhinskiy, Aleksey; Perino, Giorgio; Chojnowski, Robert; van der Meulen, Marjolein C. H.; Bostrom, Mathias P. G.; Yang, Xu

doi:https://doi.org/10.5194/jbji-6-283-2021

Articles | Volume 6, issue 7

https://doi.org/10.5194/jbji-6-283-2021

© Author(s) 2021. This work is distributed under
the Creative Commons Attribution 4.0 License.

https://doi.org/10.5194/jbji-6-283-2021

© Author(s) 2021. This work is distributed under
the Creative Commons Attribution 4.0 License.

Articles | Volume 6, issue 7

Original full-length article

|

20 Jul 2021

Original full-length article |

| 20 Jul 2021

Ceramic composite with gentamicin decreases persistent infection and increases bone formation in a rat model of debrided osteomyelitis

Aleksey Dvorzhinskiy, Giorgio Perino, Robert Chojnowski, Marjolein C. H. van der Meulen, Mathias P. G. Bostrom, and Xu Yang

Data sets

Ceramic Composite with Gentamicin Decreases Persistent Infection and Increases Bone Formation in Rat Model of Debrided Osteomyelitis Aleksey Dvorzhinskiy, Giorgio Perino, Robert Chojnowski, Marjolein C. H. van der Meulen, Mathias P. G. Bostrom, and Xu Yang https://doi.org/10.5281/zenodo.4581061

Short summary

Osteomyelitis is an infection of bone and is often treated with surgical debridement. This results in a bone defect which requires the use of a void filler. This study evaluated the use of a gentamicin-impregnated ceramic void filler (CERAMENT G) and compared it to the same void filler without antibiotic (CERAMENT) and no void filler in a rat model of osteomyelitis. CERAMENT G was found to decrease the rate of persistent infection and grow more new bone than CERAMENT or an empty defect.