Articles | Volume 9, issue 5
https://doi.org/10.5194/jbji-9-207-2024
https://doi.org/10.5194/jbji-9-207-2024
Original full-length article
 | 
24 Sep 2024
Original full-length article |  | 24 Sep 2024

Musculoskeletal infections associated with Nocardia species: a case series

Ryan B. Khodadadi, Jack W. McHugh, Supavit Chesdachai, Nancy L. Wengenack, Wendelyn Bosch, Maria Teresa Seville, Douglas R. Osmon, Elena Beam, and Zachary A. Yetmar

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Cited articles

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Clinical and Laboratory Standards Institute: Susceptibility testing of mycobacteria, Nocardia spp, and other aerobic actinomycetes, 3rd edn., Wayne: Clinical and Laboratory Standards Institute, CLSI guideline M24, 2018a. 
Clinical and Laboratory Standards Institute: Performance standards for susceptibility testing of mycobacteria, Nocardia spp, and other aerobic actinomycetes, Wayne: Clinical and Laboratory Standards Institute, CLSI guideline M62, 2018b. 
Cortes-Penfield, N., Krsak, M., Damioli, L., Henry, M., Seidelman, J., Hewlett, A., and Certain, L.: How We Approach Suppressive Antibiotic Therapy Following Debridement, Antibiotics, and Implant Retention for Prosthetic Joint Infection, Clin. Infect. Dis., 78, 188–198, https://doi.org/10.1093/cid/ciad484, 2023. 
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Short summary
In a multicenter retrospective study of musculoskeletal Nocardia infections (2011–2022), nine cases were identified. Disseminated disease occurred in 33 %, all in solid organ transplant recipients. Surgical intervention was common (89 %), with varied treatment duration (21–467 d). The 1-year mortality was 22%; all fatal cases involved disseminated disease. Localized infection generally had favorable outcomes compared to disseminated disease and requires a collaborative approach for management.