Depypere, M., Kuehl, R., Metsemakers, W. J., Senneville, E., McNally, M. A.,
Obremskey, W. T., Zimmerli, W., Atkins, B. L., and Trampuz, A.:
Recommendations for systemic antimicrobial therapy in fracture-related
infection: A consensus from an international expert group, J. Orthop.
Trauma, 34, 30-41,
https://doi.org/10.1097/bot.0000000000001626, 2020.
Freeman, C. D., Nicolau, D. P., Belliveau, P. P., and Nightingale, C. H.:
Once-daily dosing of aminoglycosides: review and recommendations for
clinical practice, J. Antimicrob. Chemother., 39, 677–686,
https://doi.org/10.1093/jac/39.6.677, 1997.
Funk, G. A., Menuey, E. M., Ensminger, W. P., Kilway, K. V., and McIff, T.
E.: Elution of rifampin and vancomycin from a weight-bearing silorane-based
bone cement, Bone. Joint. Res., 10, 277–284,
https://doi.org/10.1302/2046-3758.104.Bjr-2020-0430.R1, 2021.
Gimza, B. D. and Cassat, J. E.: Mechanisms of antibiotic failure during
Staphylococcus aureus osteomyelitis, Front. Immunol., 12, 638085, https://doi.org/10.3389/fimmu.2021.638085, 2021.
Gordon, O., Lee, D. E., Liu, B., Langevin, B., Ordonez, A. A., Dikeman, D.
A., Shafiq, B., Thompson, J. M., Sponseller, P. D., Flavahan, K., Lodge, M.
A., Rowe, S. P., Dannals, R. F., Ruiz-Bedoya, C. A., Read, T. D., Peloquin,
C. A., Archer, N. K., Miller, L. S., Davis, K. M., Gobburu, J. V. S., and Jain,
S. K.: Dynamic PET-facilitated modeling and high-dose rifampin regimens
for
Staphylococcus aureus orthopedic implant-associated infections, Sci. Transl. Med., 13,
eabl6851, https://doi.org/10.1126/scitranslmed.abl6851, 2021.
Hanssen, A. D. and Spangehl, M. J.: Practical applications of
antibiotic-loaded bone cement for treatment of infected joint replacements,
Clin. Orthop. Relat. Res., 427, 79–85,
https://doi.org/10.1097/01.blo.0000143806.72379.7d, 2004.
Henry, S. L. and Galloway, K. P.: Local antibacterial therapy for the
management of orthopaedic infections. Pharmacokinetic considerations, Clin.
Pharmacokinet., 29, 36–45,
https://doi.org/10.2165/00003088-199529010-00005, 1995.
Hossain, M. S., Mahmud, M., Sultana, S., Bin Mobarak, M., Islam, M. S., and
Ahmed, S.: Coupled effect of particle size of the source materials and
calcination temperature on the direct synthesis of hydroxyapatite, R. Soc.
Open. Sci., 8, 210684, https://doi.org/10.1098/rsos.210684,
2021.
Iundusi, R., Gasbarra, E., D'Arienzo, M., Piccioli, A., and Tarantino, U.:
Augmentation of tibial plateau fractures with an injectable bone substitute:
CERAMENT™, Three year follow-up from a prospective study, BMC
Musculoskelet. Di., 16, 115, https://doi.org/10.1186/s12891-015-0574-6, 2015.
Kaczmarczyk, J., Sowinski, P., Goch, M., and Katulska, K.: Complete twelve
month bone remodeling with a bi-phasic injectable bone substitute in benign
bone tumors: a prospective pilot study, BMC Musculoskelet. Di., 16,
369, https://doi.org/10.1186/s12891-015-0828-3, 2015.
Kotrych, D., Korecki, S., Ziętek, P., Kruk, B., Kruk, A., Wechmann, M.,
Kamiński, A., Kotrych, K., and Bohatyrewicz, A.: Preliminary results of
highly injectable bi-phasic Bbne substitute (CERAMENT) in the treatment of
benign bone tumors and tumor-like lesions, Open. Med.-Warsaw, 13, 487–492,
https://doi.org/10.1515/med-2018-0072, 2018.
Liu, Y., Raina, D. B., Sebastian, S., Nagesh, H., Isaksson, H., Engellau,
J., Lidgren, L., and Tägil, M.: Sustained and controlled delivery of
doxorubicin from an in-situ setting biphasic hydroxyapatite carrier for
local treatment of a highly proliferative human osteosarcoma, Acta
Biomater., 131, 555–571,
https://doi.org/10.1016/j.actbio.2021.07.016, 2021.
McNally, M. A., Ferguson, J. Y., Lau, A. C., Diefenbeck, M., Scarborough,
M., Ramsden, A. J., and Atkins, B. L.: Single-stage treatment of chronic
osteomyelitis with a new absorbable, gentamicin-loaded, calcium
sulphate/hydroxyapatite biocomposite: a prospective series of 100 cases,
Bone Joint. J., 98-b, 1289–1296, https://doi.org/10.1302/0301-620x.98b9.38057, 2016.
McNally, M. A., Ferguson, J. Y., Scarborough, M., Ramsden, A., Stubbs, D.
A., and Atkins, B. L.: Mid- to long-term results of single-stage surgery for
patients with chronic osteomyelitis using a bioabsorbable gentamicin-loaded
ceramic carrier, Bone Joint. J., 104-b, 1095–1100,
https://doi.org/10.1302/0301-620x.104b9.Bjj-2022-0396.R1, 2022.
Metsemakers, W. J., Kuehl, R., Moriarty, T. F., Richards, R. G., Verhofstad,
M. H. J., Borens, O., Kates, S., and Morgenstern, M.: Infection after
fracture fixation: Current surgical and microbiological concepts, Injury,
49, 511–522, https://doi.org/10.1016/j.injury.2016.09.019,
2018.
Nair, A. B. and Jacob, S.: A simple practice guide for dose conversion
between animals and human, J. Basic Clin. Pharm., 7, 27–31,
https://doi.org/10.4103/0976-0105.177703, 2016.
Neut, D., van de Belt, H., Stokroos, I., van Horn, J. R., van der Mei, H.
C., and Busscher, H. J.: Biomaterial-associated infection of
gentamicin-loaded PMMA beads in orthopaedic revision surgery, J. Antimicrob.
Chemother., 47, 885–891, https://doi.org/10.1093/jac/47.6.885, 2001.
Nilsson, M., Zheng, M. H., and Tägil, M.: The composite of
hydroxyapatite and calcium sulphate: a review of preclinical evaluation and
clinical applications, Expert Rev. Med. Devic., 10, 675–684,
https://doi.org/10.1586/17434440.2013.827529, 2013.
Osmon, D. R., Berbari, E. F., Berendt, A. R., Lew, D., Zimmerli, W.,
Steckelberg, J. M., Rao, N., Hanssen, A., and Wilson, W. R.: Diagnosis and
management of prosthetic joint infection: clinical practice guidelines by
the Infectious Diseases Society of America, Clin. Infect. Dis., 56,
e1–e25, https://doi.org/10.1093/cid/cis803, 2013.
Qayoom, I., Teotia, A. K., Panjla, A., Verma, S., and Kumar, A.: Local and
sustained delivery of rifampicin from a bioactive ceramic carrier treats
bone infection in Rat Tibia, ACS Infect. Dis., 6, 2938–2949,
https://doi.org/10.1021/acsinfecdis.0c00369, 2020.
Raina, D. B., Liu, Y., Isaksson, H., Tägil, M., and Lidgren, L.:
Synthetic hydroxyapatite: a recruiting platform for biologically active
molecules, Acta Orthop., 91, 126–132,
https://doi.org/10.1080/17453674.2019.1686865, 2020a.
Raina, D. B., Liu, Y., Jacobson, O. L. P., Tanner, K. E., Tägil, M., and
Lidgren, L.: Bone mineral as a drug-seeking moiety and a waste dump, Bone.
Joint. Res., 9, 709–718,
https://doi.org/10.1302/2046-3758.910.Bjr-2020-0097.R1, 2020b.
Sebastian, S., Malhotra, R., Dhawan, B., Sreenivas, V., Kapil, A., and
Chaudhry, R.: Sonication of antibiotic loaded cement spacers: A valuable
technique for detection of infection persistence in two-stage revision for
infected joint arthroplasty, Indian J. Med. Microbi., 37, 99–101,
https://doi.org/10.4103/ijmm.IJMM_18_313, 2019.
Sebastian, S., Sezgin, E. A., Stučinskas, J., Tarasevičius, Š.,
Liu, Y., Raina, D. B., Tägil, M., Lidgren, L., and W-Dahl, A.: Different
microbial and resistance patterns in primary total knee arthroplasty
infections – a report on 283 patients from Lithuania and Sweden, BMC
Musculoskelet. Di., 22, 800,
https://doi.org/10.1186/s12891-021-04689-5, 2021.
Sebastian, S., Tandberg, F., Liu, Y., Tägil, M., Lidgren, L., and Raina,
D. B.: A Targeted drug delivery approach in deep bone infections using synthetic hydroxyapatite as a recruiting moiety, ORS 2022 Annual Meeting, 4–8 February, Tampa, Florida, Abstract no. 0031,
2022a.
Sebastian, S., Tandberg, F., Liu, Y., Raina, D. B., Tägil, M., Collin, M.,
and Lidgren, L.: Extended local release and improved bacterial eradication
by adding rifampicin to a biphasic ceramic carrier containing gentamicin or
vancomycin, Bone. Joint. Res., 11, 787–802, https://doi.org/10.1302/2046-3758.1111.BJR-2022-0101.R1, 2022b.
Sendi, P. and Zimmerli, W.: The use of rifampin in staphylococcal
orthopaedic-device-related infections, Clin. Microbiol. Infect., 23,
349–350, https://doi.org/10.1016/j.cmi.2016.10.002, 2017.
Stravinskas, M., Horstmann, P., Ferguson, J., Hettwer, W., Nilsson, M.,
Tarasevicius, S., Petersen, M. M., McNally, M. A., and Lidgren, L.:
Pharmacokinetics of gentamicin eluted from a regenerating bone graft
substitute: In vitro and clinical release studies, Bone. Joint. Res., 5,
427–435, https://doi.org/10.1302/2046-3758.59.Bjr-2016-0108.R1,
2016.
Stravinskas, M., Tarasevicius, S., Laukaitis, S., Nilsson, M., Raina, D. B.,
and Lidgren, L.: A ceramic bone substitute containing gentamicin gives good
outcome in trochanteric hip fractures treated with dynamic hip screw and in
revision of total hip arthroplasty: a case series, BMC Musculoskelet.
Di., 19, 438, https://doi.org/10.1186/s12891-018-2360-8,
2018.
Stravinskas, M., Nilsson, M., Vitkauskiene, A., Tarasevicius, S., and
Lidgren, L.: Vancomycin elution from a biphasic ceramic bone substitute,
Bone Joint. Res., 8, 49–54, https://doi.org/10.1302/2046-3758.82.Bjr-2018-0174.R2, 2019.
Vandiver, J., Dean, D., Patel, N., Bonfield, W., and Ortiz, C.: Nanoscale
variation in surface charge of synthetic hydroxyapatite detected by
chemically and spatially specific high-resolution force spectroscopy,
Biomaterials, 26, 271–283,
https://doi.org/10.1016/j.biomaterials.2004.02.053, 2005.
Zimmerli, W. and Sendi, P.: Role of Rifampin against staphylococcal biofilm
Infections in vitro, in animal models, and in orthopedic-device-related
infections, Antimicrob. Agents Ch., 63, e01746-18,
https://doi.org/10.1128/aac.01746-18, 2019.
