Articles | Volume 8, issue 1
https://doi.org/10.5194/jbji-8-19-2023
https://doi.org/10.5194/jbji-8-19-2023
Original full-length article
 | 
09 Jan 2023
Original full-length article |  | 09 Jan 2023

Systemic rifampicin shows accretion to locally implanted hydroxyapatite particles in a rat abdominal muscle pouch model

Sujeesh Sebastian, Jintian Huang, Yang Liu, Mattias Collin, Magnus Tägil, Deepak Bushan Raina, and Lars Lidgren

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Subject: Biomaterials | Topic: All topics
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Cited articles

Alagboso, F. I., Mannala, G. K., Walter, N., Docheva, D., Brochhausen, C., Alt, V., and Rupp, M.: Rifampicin restores extracellular organic matrix formation and mineralization of osteoblasts after intracellular Staphylococcus aureus infection, Bone. Joint. Res., 11, 327–341, https://doi.org/10.1302/2046-3758.115.Bjr-2021-0395.R1, 2022. 
Anagnostakos, K., Hitzler, P., Pape, D., Kohn, D., and Kelm, J.: Persistence of bacterial growth on antibiotic-loaded beads: is it actually a problem?, Acta. Orthop., 79, 302–307, https://doi.org/10.1080/17453670710015120, 2008. 
Anagnostakos, K., Wilmes, P., Schmitt, E., and Kelm, J.: Elution of gentamicin and vancomycin from polymethylmethacrylate beads and hip spacers in vivo, Acta. Orthop., 80, 193–197, https://doi.org/10.3109/17453670902884700, 2009. 
Buchholz, H. W. and Engelbrecht, H.: Depot effects of various antibiotics mixed with Palacos resins, Chirurg, 41, 511–515, 1970. 
Chen, Y., Wu, X., Li, J., Jiang, Y., Xu, K., and Su, J.: Bone-targeted nanoparticle drug delivery system: an emerging strategy for bone-related disease, Front. Pharmacol., 13, 909408, https://doi.org/10.3389/fphar.2022.909408, 2022. 
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Short summary
Currently, there is no method available to reload antibiotic carriers to treat late bone infections or to prevent bacterial attachment. We propose a novel method to load and protect a biphasic calcium sulfate/hydroxyapatite (CaS/HA) carrier material from bacterial re-population by systemically administering a clinical dose of HA-seeking antibiotic rifampicin (RIF). CaS/HA-based carriers could recruit HA-seeking RIF to locally exert an adequate antibacterial effect at the targeted tissue.