Journal of Bone and Joint Infection
Journal of Bone and Joint Infection
JBJI
Articles | Volume 8, issue 1
Articles | Volume 8, issue 1
https://doi.org/10.5194/jbji-8-19-2023
© Author(s) 2023. This work is distributed under
the Creative Commons Attribution 4.0 License.
https://doi.org/10.5194/jbji-8-19-2023
© Author(s) 2023. This work is distributed under
the Creative Commons Attribution 4.0 License.
Articles | Volume 8, issue 1
Original full-length article
 | 
09 Jan 2023
Original full-length article |  | 09 Jan 2023

Systemic rifampicin shows accretion to locally implanted hydroxyapatite particles in a rat abdominal muscle pouch model

Sujeesh Sebastian, Jintian Huang, Yang Liu, Mattias Collin, Magnus Tägil, Deepak Bushan Raina, and Lars Lidgren

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Latest update: 27 Oct 2025
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Short summary
Currently, there is no method available to reload antibiotic carriers to treat late bone infections or to prevent bacterial attachment. We propose a novel method to load and protect a biphasic calcium sulfate/hydroxyapatite (CaS/HA) carrier material from bacterial re-population by systemically administering a clinical dose of HA-seeking antibiotic rifampicin (RIF). CaS/HA-based carriers could recruit HA-seeking RIF to locally exert an adequate antibacterial effect at the targeted tissue.
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