Journal of Bone and Joint Infection
Journal of Bone and Joint Infection
JBJI
Articles | Volume 8, issue 1
Articles | Volume 8, issue 1
https://doi.org/10.5194/jbji-8-19-2023
© Author(s) 2023. This work is distributed under
the Creative Commons Attribution 4.0 License.
https://doi.org/10.5194/jbji-8-19-2023
© Author(s) 2023. This work is distributed under
the Creative Commons Attribution 4.0 License.
Articles | Volume 8, issue 1
Original full-length article
 | 
09 Jan 2023
Original full-length article |  | 09 Jan 2023

Systemic rifampicin shows accretion to locally implanted hydroxyapatite particles in a rat abdominal muscle pouch model

Sujeesh Sebastian, Jintian Huang, Yang Liu, Mattias Collin, Magnus Tägil, Deepak Bushan Raina, and Lars Lidgren

Viewed

Total article views: 750 (including HTML, PDF, and XML)
HTML PDF XML Total BibTeX EndNote
555 155 40 750 31 38
  • HTML: 555
  • PDF: 155
  • XML: 40
  • Total: 750
  • BibTeX: 31
  • EndNote: 38
Views and downloads (calculated since 09 Jan 2023)
Cumulative views and downloads (calculated since 09 Jan 2023)

Viewed (geographical distribution)

Total article views: 718 (including HTML, PDF, and XML) Thereof 718 with geography defined and 0 with unknown origin.
Country # Views %
  • 1
1
 
 
 
 

Cited

Latest update: 20 Nov 2024
Download
Short summary
Currently, there is no method available to reload antibiotic carriers to treat late bone infections or to prevent bacterial attachment. We propose a novel method to load and protect a biphasic calcium sulfate/hydroxyapatite (CaS/HA) carrier material from bacterial re-population by systemically administering a clinical dose of HA-seeking antibiotic rifampicin (RIF). CaS/HA-based carriers could recruit HA-seeking RIF to locally exert an adequate antibacterial effect at the targeted tissue.
Read more