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Journal of Bone and Joint Infection An open-access journal of the European Bone and Joint Infection Society and the MusculoSkeletal Infection Society
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Costs related to off-label expensive antibiotics used to treat bone and joint infections (BJIs) in a referral centre in France were analysed in this cohort study. Despite the large increase in the number of patients treated with these antibiotics, the overall costs remained stable (approximately EUR 1 million) and were helped by the appearance of generic molecules at lower prices. Production of generic antibiotics at low cost is essential to limit the financial burden of the management of BJIs.
JBJI | Articles | Volume 6, issue 8
J. Bone Joint Infect., 6, 337–346, 2021
https://doi.org/10.5194/jbji-6-337-2021
J. Bone Joint Infect., 6, 337–346, 2021
https://doi.org/10.5194/jbji-6-337-2021

Original full-length article 07 Sep 2021

Original full-length article | 07 Sep 2021

Cost of off-label antibiotic therapy for bone and joint infections: a 6-year prospective monocentric observational cohort study in a referral centre for management of complex osteo-articular infections

Truong-Thanh Pham et al.

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Association for Accessible Medicines: 2020 Generic Drug & Biosimilars Access & Savings in the U.S. Report, available at: https://accessiblemeds.org/2020-Access-Savings-Report, last access: 14 June 2021. 
Berbari, E. F., Kanj, S. S., Kowalski, T. J., Darouiche, R. O., Widmer, A. F., Schmitt, S. K., Hendershot, E. F., Holtom, P. D., Huddleston 3rd, P. M., Petermann, G. W., Osmon, D. R., and Infectious Diseases Society of, A.: 2015 Infectious Diseases Society of America (IDSA) Clinical Practice Guidelines for the Diagnosis and Treatment of Native Vertebral Osteomyelitis in Adults, Clin. Infect. Dis., 61, e26–46, https://doi.org/10.1093/cid/civ482, 2015. 
Carvalhaes, C. G., Sader, H. S., Flamm, R. K., and Mendes, R. E.: Tedizolid in vitro activity against Gram-positive clinical isolates causing bone and joint infections in hospitals in the USA and Europe (2014–17), J. Antimicrob. Chemother., 74, 1928–1933, https://doi.org/10.1093/jac/dkz120, 2019. 
da Silva, R. B. and Salles, M. J.: Outcomes and Risk Factors in Prosthetic Joint Infections by multidrug-resistant Gram-negative Bacteria: A Retrospective Cohort Study, Antibiotics (Basel), 23, 340, https://doi.org/10.3390/antibiotics10030340, 2021. 
Decollogny, A., Eggli, Y., Halfon, P., and Lufkin, T. M.: Determinants of generic drug substitution in Switzerland, BMC Health Serv. Res., 11, 17, https://doi.org/10.1186/1472-6963-11-17, 2011. 
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Short summary
Costs related to off-label expensive antibiotics used to treat bone and joint infections (BJIs) in a referral centre in France were analysed in this cohort study. Despite the large increase in the number of patients treated with these antibiotics, the overall costs remained stable (approximately EUR 1 million) and were helped by the appearance of generic molecules at lower prices. Production of generic antibiotics at low cost is essential to limit the financial burden of the management of BJIs.
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