Journal of Bone and Joint Infection
Journal of Bone and Joint Infection
JBJI
Articles | Volume 11, issue 1
Articles | Volume 11, issue 1
https://doi.org/10.5194/jbji-11-77-2026
© Author(s) 2026. This work is distributed under
the Creative Commons Attribution 4.0 License.
https://doi.org/10.5194/jbji-11-77-2026
© Author(s) 2026. This work is distributed under
the Creative Commons Attribution 4.0 License.
Articles | Volume 11, issue 1
Review
 | 
05 Feb 2026
Review |  | 05 Feb 2026

Lyme in the prosthetic joint: two cases and a review of the literature

Hussam Tabaja, Matteo Passerini, Irene G. Sia, Elena Beam, and Gina A. Suh

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Short summary
In Lyme-endemic regions, Lyme disease should be considered in culture-negative periprosthetic joint infection (PJI). Diagnosis relies on microbial DNA detection, particularly Borrelia-targeted polymerase chain reaction (PCR) on synovial fluid or tissue. We present 10 cases highlighting the value of PCR for early recognition of this pathogen, which is not detectable by conventional culture media. Surgical debridement remains the standard of care, though several cases were successfully treated medically, an observation that merits further investigation.
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