Articles | Volume 11, issue 1
https://doi.org/10.5194/jbji-11-65-2026
© Author(s) 2026. This work is distributed under
the Creative Commons Attribution 4.0 License.
the Creative Commons Attribution 4.0 License.
https://doi.org/10.5194/jbji-11-65-2026
© Author(s) 2026. This work is distributed under
the Creative Commons Attribution 4.0 License.
the Creative Commons Attribution 4.0 License.
Gentamicin fails to eradicate Staphylococcus aureus biofilm in vitro, even in combination with rifampin
Willemijn Boot
AO Research Institute Davos, 7270 Davos, Switzerland
Michel Schläppi
Division of Orthopaedics and Traumatology, Cantonal Hospital Winterthur, 8401 Winterthur, Switzerland
Virginia Post
AO Research Institute Davos, 7270 Davos, Switzerland
T. Fintan Moriarty
AO Research Institute Davos, 7270 Davos, Switzerland
Endo-Team, Birshof Hospital, 4142 Muenchenstein, Switzerland
Department of Biomedical Engineering, University of Basel, 4123 Allschwil, Switzerland
ARTORG Centre for Biomedical Engineering Research, Faculty of Medicine, University of Bern, 3008 Bern, Switzerland
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Baixing Chen, T. Fintan Moriarty, Hans Steenackers, Georges F. Vles, Jolien Onsea, Thijs Vackier, Isabel Spriet, Rob Lavigne, R. Geoff Richards, and Willem-Jan Metsemakers
J. Bone Joint Infect., 9, 249–260, https://doi.org/10.5194/jbji-9-249-2024, https://doi.org/10.5194/jbji-9-249-2024, 2024
Short summary
Short summary
Our research explores natural antimicrobials to combat orthopedic-device-related infections, a challenging issue due to antibiotic resistance. We reviewed agents from bacteria, fungi, viruses, animals, plants and minerals, evaluating their effectiveness and synergy with traditional antibiotics. Our findings suggest these natural alternatives could revolutionize infection management in orthopedic patients, offering new hope for reducing antibiotic resistance and improving treatment outcomes.
Alexandra Wallimann, Yvonne Achermann, Ciara Ferris, Mario Morgenstern, Martin Clauss, Vincent Stadelmann, Hannes Andreas Rüdiger, Liam O'Mahony, and Thomas Fintan Moriarty
J. Bone Joint Infect., 9, 191–196, https://doi.org/10.5194/jbji-9-191-2024, https://doi.org/10.5194/jbji-9-191-2024, 2024
Short summary
Short summary
Skin commensal bacteria such as staphylococci are often the source of orthopaedic-device-related infections. Rifampicin is a widely used antibiotic in the treatment of these infections. The results of this study show that oral rifampicin therapy leads to a consistent and persistent induction of resistance in commensal staphylococci on the skin and in the nose for a prolonged time.
Katharina Reinisch, Michel Schläppi, Christoph Meier, and Peter Wahl
J. Bone Joint Infect., 7, 11–21, https://doi.org/10.5194/jbji-7-11-2022, https://doi.org/10.5194/jbji-7-11-2022, 2022
Short summary
Short summary
Despite potential pharmacokinetic advantages, the local application of antibiotics in the treatment of periprosthetic joint infections has so far been associated with bad outcomes. This study shows a major advantage for the local application of antibiotics with calcium sulfate as the carrier material in the implant-retaining treatment of a periprosthetic joint infection of the hip.
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Short summary
In this study, we tested whether very high doses and prolonged exposure of gentamicin, alone or with rifampin, can eliminate mature Staphylococcus aureus biofilm – one of the main causes of implant-associated infections. None of the regimes tested eradicated all bacteria. Adding rifampin gave no benefit. This suggests that aminoglycosides are not optimal for local antibiotic therapy.
In this study, we tested whether very high doses and prolonged exposure of gentamicin, alone or...