Journal of Bone and Joint Infection
Journal of Bone and Joint Infection
JBJI
Articles | Volume 11, issue 1
Articles | Volume 11, issue 1
https://doi.org/10.5194/jbji-11-65-2026
© Author(s) 2026. This work is distributed under
the Creative Commons Attribution 4.0 License.
https://doi.org/10.5194/jbji-11-65-2026
© Author(s) 2026. This work is distributed under
the Creative Commons Attribution 4.0 License.
Articles | Volume 11, issue 1
Original full-length article
 | 
02 Feb 2026
Original full-length article |  | 02 Feb 2026

Gentamicin fails to eradicate Staphylococcus aureus biofilm in vitro, even in combination with rifampin

Willemijn Boot, Michel Schläppi, Virginia Post, T. Fintan Moriarty, and Peter Wahl

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Short summary
In this study, we tested whether very high doses and prolonged exposure of gentamicin, alone or with rifampin, can eliminate mature Staphylococcus aureus biofilm – one of the main causes of implant-associated infections. None of the regimes tested eradicated all bacteria. Adding rifampin gave no benefit. This suggests that aminoglycosides are not optimal for local antibiotic therapy.
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