Journal of Bone and Joint Infection
Journal of Bone and Joint Infection
JBJI
Articles | Volume 8, issue 1
Articles | Volume 8, issue 1
https://doi.org/10.5194/jbji-8-45-2023
© Author(s) 2023. This work is distributed under
the Creative Commons Attribution 4.0 License.
https://doi.org/10.5194/jbji-8-45-2023
© Author(s) 2023. This work is distributed under
the Creative Commons Attribution 4.0 License.
Articles | Volume 8, issue 1
Original full-length article
 | 
18 Jan 2023
Original full-length article |  | 18 Jan 2023

First evaluation of a commercial multiplex PCR panel for rapid detection of pathogens associated with acute joint infections

Jorrit Willem Adriaan Schoenmakers, Rosanne de Boer, Lilli Gard, Greetje Anna Kampinga, Marleen van Oosten, Jan Maarten van Dijl, Paulus Christiaan Jutte, and Marjan Wouthuyzen-Bakker

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Cited articles

Arvieux, C. and Common, H.: New diagnostic tools for prosthetic joint infection, Orthop. Traumatol. Surg. Res., 105, S23–S30, https://doi.org/10.1016/j.otsr.2018.04.029, 2019. 
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Berneking, L., Haas, M., Frielinghaus, L., Berinson, B., Lütgehetmann, M., Christner, M., Aepfelbacher, M., Gerlach, U., Seide, K., Both, A., and Rohde, H.: Evaluation of a syndromic panel polymerase chain reaction (spPCR) assay for the diagnosis of device-associated bone and joint infections (BJI), Int. J. Infect. Dis., 116, 283–288, https://doi.org/10.1016/j.ijid.2022.01.013, 2022. 
Cunha, C. B. and Opal, S. M.: Antibiotic Stewardship: Strategies to Minimize Antibiotic Resistance While Maximizing Antibiotic Effectiveness, Med. Clin. North Am., 102, 831–843, https://doi.org/10.1016/j.mcna.2018.04.006, 2018. 
Fye, K.: Arthrocentesis, synovial fluid analysis, and synovial biopsy, in: Primer on the Rheumatic Diseases, edited by: Klippel, J. H., 13th edn., Atlanta, USA, 2008. 
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In a first evaluation, the accuracy of a novel multiplex PCR (polymerase chain reaction) panel for rapid detection of pathogens in patients with a clinical suspicion of acute septic arthritis of native and prosthetic joints is assessed. Clear benefit is seen in patients with a suspected native septic arthritis and late acute prosthetic joint infection. This indicates that the panel allows for fast tailoring of antibiotics and may prompt the surgeon for surgical lavage in doubtful clinical cases.
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