Articles | Volume 8, issue 3
https://doi.org/10.5194/jbji-8-175-2023
https://doi.org/10.5194/jbji-8-175-2023
Original full-length article
 | 
28 Jun 2023
Original full-length article |  | 28 Jun 2023

Dalbavancin is thermally stable at clinically relevant temperatures against methicillin-sensitive Staphylococcus Aureus

Aaron K. Hoyt, Patrick Lawler, Mathias Bostrom, Alberto V. Carli, and Ashley E. Levack

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Cited articles

Almangour, T. A., Perry, G. K., Terriff, C. M., Alhifany, A. A., and Kaye, K. S.: Dalbavancin for the management of gram-positive osteomyelitis: Effectiveness and potential utility, Diagn. Microbiol. Infect. Dis., 93, 213–218, https://doi.org/10.1016/j.diagmicrobio.2018.10.007, 2019. 
Appelbaum, P. C.: Reduced glycopeptide susceptibility in methicillin-resistant Staphylococcus aureus (MRSA), Int. J. Antimicrob. Agents, 30, 398–408, https://doi.org/10.1016/j.ijantimicag.2007.07.011, 2007. 
Berend, K. R., Lombardi Jr., A. V., Morris, M. J., Bergeson, A. G., Adams, J. B., and Sneller, M. A.: Two-stage treatment of hip periprosthetic joint infection is associated with a high rate of infection control but high mortality, Clin. Orthop. Relat. Res., 471, 510–518, https://doi.org/10.1007/s11999-012-2595-x, 2013. 
Biedenbach, D. J., Ross, J. E., Fritsche, T. R., Sader, H. S., and Jones, R. N.: Activity of dalbavancin tested against Staphylococcus spp. and beta-hemolytic Streptococcus spp. isolated from 52 geographically diverse medical centers in the United States, J. Clin. Microbiol., 45, 998–1004, https://doi.org/10.1128/JCM.02368-06, 2007. 
Biedenbach, D. J., Bell, J. M., Sader, H. S., Turnidge, J. D., and Jones, R. N.: Activities of dalbavancin against a worldwide collection of 81,673 gram-positive bacterial isolates, Antimicrob. Agents Chemother., 53, 1260–1263, https://doi.org/10.1128/AAC.01453-08, 2009. 
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Short summary
This study investigates the ability of a promising new antibiotic, dalbavancin, to be used as an antibiotic incorporated into polymethyl methacrylate (PMMA) cement or other carriers (such as calcium sulfate) to treat bone and joint infections. For antibiotics to be used locally, they must retain their efficacy after heat exposure during PMMA polymerization and at human core body temperature. This study demonstrates that dalbavancin is stable at the temperatures required for local use.