Journal of Bone and Joint Infection
Journal of Bone and Joint Infection
JBJI
Articles | Volume 8, issue 3
Articles | Volume 8, issue 3
https://doi.org/10.5194/jbji-8-175-2023
© Author(s) 2023. This work is distributed under
the Creative Commons Attribution 4.0 License.
https://doi.org/10.5194/jbji-8-175-2023
© Author(s) 2023. This work is distributed under
the Creative Commons Attribution 4.0 License.
Articles | Volume 8, issue 3
Original full-length article
 | 
28 Jun 2023
Original full-length article |  | 28 Jun 2023

Dalbavancin is thermally stable at clinically relevant temperatures against methicillin-sensitive Staphylococcus Aureus

Aaron K. Hoyt, Patrick Lawler, Mathias Bostrom, Alberto V. Carli, and Ashley E. Levack

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Short summary
This study investigates the ability of a promising new antibiotic, dalbavancin, to be used as an antibiotic incorporated into polymethyl methacrylate (PMMA) cement or other carriers (such as calcium sulfate) to treat bone and joint infections. For antibiotics to be used locally, they must retain their efficacy after heat exposure during PMMA polymerization and at human core body temperature. This study demonstrates that dalbavancin is stable at the temperatures required for local use.
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