Articles | Volume 7, issue 2
https://doi.org/10.5194/jbji-7-91-2022
https://doi.org/10.5194/jbji-7-91-2022
Original full-length article
 | 
20 Apr 2022
Original full-length article |  | 20 Apr 2022

Standardized quantification of biofilm in a novel rabbit model of periprosthetic joint infection

Anabelle Visperas, Daniel Santana, Minseon Ju, Nathalie B. Milbrandt, Yu Hsin Tsai, Sameera Wickramasinghe, Alison K. Klika, Nicolas S. Piuzzi, Anna Cristina S. Samia, and Carlos A. Higuera-Rueda

Related subject area

Subject: Prosthesis-related infections | Topic: Other
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Eytan M. Debbi, Tyler Khilnani, Ioannis Gkiatas, Yu-Fen Chiu, Andy O. Miller, Michael W. Henry, and Alberto V. Carli
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Cited articles

Belmatoug, N., Crémieux, A. C., Bleton, R., Volk, A., Saleh-Mghir, A., Grossin, M., Garry, L., and Carbon, C.: A new model of experimental prosthetic joint infection due to methicillin-resistant Staphylococcus aureus: a microbiologic, histopathologic, and magnetic resonance imaging characterization, J. Infect. Dis., 174, 414–7, https://doi.org/10.1093/infdis/174.2.414, 1996. 
Breyne, K., Honaker, R. W., Hobbs, Z., Richter, M., Zaczek, M., Spangler, T., Steenbrugge, J., Lu, R., Kinkhabwala, A., Marchon, B., Meyer, E., and Mokres, L.: Efficacy and safety of a Bovine-Associated Staphylococcus aureus Phage Cocktail in a murine model of mastitis, Front. Microbiol., 8, 2348, https://doi.org/10.3389/fmicb.2017.02348, 2017. 
Carli, A., Ross, F., Bhimani, S., Nodzo, S., and Bostrom, M.: Developing a Clinically Representative Model of Periprosthetic Joint Infection, J. Bone Joint Surg. Am., 98, 1666–1676, https://doi.org/10.2106/jbjs.15.01432, 2016. 
Carli, A. V., Bhimani, S., Yang, X., Shirley, M. B., de Mesy Bentley, K. L., Ross, F. P., and Bostrom, M. P. G.: Quantification of Peri-Implant Bacterial Load and in Vivo Biofilm Formation in an Innovative, Clinically Representative Mouse Model of Periprosthetic Joint Infection, J. Bone Joint Surg., 99, e25, https://doi.org/10.2106/JBJS.16.00815, 2017. 
Craig, M. R., Poelstra, K. A., Sherrell, J. C., Kwon, M. S., Belzile, E. L., and Brown, T. E.: A novel total knee arthroplasty infection model in rabbits, J. Orthop. Res., 23, 1100–4, https://doi.org/10.1016/j.orthres.2005.03.007, 2005. 
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Short summary
Periprosthetic joint infection (PJI) is a complication of total joint arthroplasty, and treatment failure rates are still quite high. This study has developed a novel rabbit model of PJI that provides an opportunity to introduce treatments during ongoing infection, with readouts including a quantifiable method to assess biofilm coverage on implants via scanning electron microscopy (SEM).