Articles | Volume 7, issue 6
https://doi.org/10.5194/jbji-7-279-2022
© Author(s) 2022. This work is distributed under
the Creative Commons Attribution 4.0 License.
the Creative Commons Attribution 4.0 License.
https://doi.org/10.5194/jbji-7-279-2022
© Author(s) 2022. This work is distributed under
the Creative Commons Attribution 4.0 License.
the Creative Commons Attribution 4.0 License.
Original full-length article
| 
21 Dec 2022
Original full-length article |
| 21 Dec 2022
| 21 Dec 2022
Osteosynthesis-associated infection of the lower limbs by multidrug-resistant and extensively drug-resistant Gram-negative bacteria: a multicentre cohort study
Efthymia Giannitsioti
CORRESPONDING AUTHOR
Fourth Department of Internal Medicine, University General Hospital Attikon, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece
Mauro José Salles
Division of Infectious Diseases, Department of Internal Medicine, Escola Paulista de Medicina, Universidade Federal de São Paulo (UNIFESP), São Paulo, Brazil
Andreas Mavrogenis
First Department of Orthopaedics, University General Hospital Attikon, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece
Dolors Rodriguez-Pardo
Department of Infectious Diseases, Hospital Universitari Vall d'Hebron, Barcelona, Spain
Ibai Los-Arcos
Department of Infectious Diseases, Hospital Universitari Vall d'Hebron, Barcelona, Spain
Alba Ribera
Department of Infectious Diseases, Hospital Universitari Bellvitge, Barcelona, Spain
Javier Ariza
Department of Infectious Diseases, Hospital Universitari Bellvitge, Barcelona, Spain
María Dolores del Toro
Infectious Diseases Unit, Hospital Universitario Virgen Macarena, Instituto de Biomedicina de Sevilla (IBIS), Universidad de Sevilla, Seville, Spain
Sophie Nguyen
Infectious Diseases Department, Gustave Dron Hospital, Tourcoing, France
Eric Senneville
Infectious Diseases Department, Gustave Dron Hospital, Tourcoing, France
Eric Bonnet
Department of Infectious Diseases, Clinique Pasteur, Toulouse, France
Monica Chan
Department of Infectious Diseases, Tan Tock Seng Hospital, Singapore, Singapore
Maria Bruna Pasticci
Infectious Diseases Unit, University of Perugia, Perugia, Italy
Sabine Petersdorf
Institute for Medical Laboratory Diagnostics, Helios University Clinic Wuppertal, Wuppertal, Germany
Natividad Benito
Infectious Diseases Unit, Hospital de la Santa Creu i Sant Pau, Institut d'Investigació Biomèdica Sant Pau, Universitat Autònoma de Barcelona, Barcelona, Spain
Nuala O' Connell
Department of Clinical Microbiology, University Hospital Limerick, Limerick, Ireland
Antonio Blanco García
Bone and Joint Infection Unit, Department of Emergency Medicine, IIS-Fundación Jiménez Díaz Hospital, Madrid, Spain
Gábor Skaliczki
Department of Orthopaedics, Semmelweis University, Budapest, Hungary
Pierre Tattevin
Infectious Diseases and Intensive Care Unit, Pontchaillou University Hospital, Rennes, France
Zeliha Kocak Tufan
Department of Infectious Diseases and Clinical Microbiology, Faculty of Medicine, Yildirim Beyazit University, Ankara Atatürk Education and Research Hospital, Ankara, Turkey
Nikolaos Pantazis
Department of Hygiene, Epidemiology and Medical Statistics, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece
Panayiotis D. Megaloikonomos
First Department of Orthopaedics, University General Hospital Attikon, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece
Panayiotis Papagelopoulos
First Department of Orthopaedics, University General Hospital Attikon, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece
Alejandro Soriano
Department of Infectious Diseases, Hospital Clínic, Barcelona, University of Barcelona, IDIBAPS, Barcelona, Spain
Antonios Papadopoulos
Fourth Department of Internal Medicine, University General Hospital Attikon, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece
A full list of authors appears at the end of the paper.
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Short summary
Our multicentre study on a lower-limb osteosynthesis-associated infection (OAI) cohort by multidrug (MDR) and extensively drug (XDR) resistant Gram-negative bacteria found the following: implant retention with debridement was mostly performed in early OAI; 50.9 % of patients achieved remission of infection; remission reached 50 % (MDR) vs. 25 % (XDR) in early OAI and 60 % (MDR) vs. 44.4 % (XDR) in late OAI; age (> 60) and multiple surgeries were independent factors influencing lack of remission.
Our multicentre study on a lower-limb osteosynthesis-associated infection (OAI) cohort by...
