Articles | Volume 7, issue 6
https://doi.org/10.5194/jbji-7-249-2022
© Author(s) 2022. This work is distributed under
the Creative Commons Attribution 4.0 License.
the Creative Commons Attribution 4.0 License.
https://doi.org/10.5194/jbji-7-249-2022
© Author(s) 2022. This work is distributed under
the Creative Commons Attribution 4.0 License.
the Creative Commons Attribution 4.0 License.
Review
| 
23 Nov 2022
Review |
| 23 Nov 2022
| 23 Nov 2022
Early switch to oral antibiotic therapy for the treatment of patients with bacterial native vertebral osteomyelitis: a quaternary center experience, systematic review, and meta-analysis
Matteo Passerini
CORRESPONDING AUTHOR
Division of Public Health, Infectious Diseases, and Occupational
Medicine, Mayo Clinic, Rochester, MN 55905, USA
Julian Maamari
Division of Public Health, Infectious Diseases, and Occupational
Medicine, Mayo Clinic, Rochester, MN 55905, USA
Tarek Nayfeh
Division of Public Health, Infectious Diseases, and Occupational
Medicine, Mayo Clinic, Rochester, MN 55905, USA
Leslie C. Hassett
Mayo Clinic Libraries, Mayo Clinic, Rochester, MN 55905, USA
Aaron J. Tande
Division of Public Health, Infectious Diseases, and Occupational
Medicine, Mayo Clinic, Rochester, MN 55905, USA
Mohammad H. Murad
Division of Public Health, Infectious Diseases, and Occupational
Medicine, Mayo Clinic, Rochester, MN 55905, USA
Zelalem Temesgen
Division of Public Health, Infectious Diseases, and Occupational
Medicine, Mayo Clinic, Rochester, MN 55905, USA
Elie F. Berbari
CORRESPONDING AUTHOR
Division of Public Health, Infectious Diseases, and Occupational
Medicine, Mayo Clinic, Rochester, MN 55905, USA
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Physicians have difficulties interpreting the isolation of Cutibacterium acnes in the spine tissue. Here we provide the experience of our center about this topic, adding data that can help physicians in their choices. Our results show that some clinical, radiological, and microbiological features can help distinguish patients to treat or not to treat. Moreover, treatment with parenteral beta-lactams appears to be effective, but targeted oral therapy could be a valid alternative.
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This retrospective case-matched study evaluated males and females with staphylococcal PJI (periprosthetic joint infection) treated with two-stage exchange arthroplasty. We matched 156 males and females for age, type of staphylococcal infection, and joint involved. We compared clinical parameters related to presentation, treatment, and outcome. We did not find a statistically significant difference in outcome between males and females treated with the same surgical approach at our institution.
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In this study, we prospectively enrolled patients with a suspected diagnosis of native vertebral osteomyelitis (NVO) undergoing image-guided needle aspiration of the intervertebral disc. Based on this pilot study, a high manual cell count or a high neutrophilic predominance from the disc aspirate was associated with the diagnosis of NVO.
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This paper describes five cases of prosthetic joint infection (PJI) caused by Mycobacterium avium complex (MAC). Infections occurred in both immune competent and immunosuppressed patients. Interestingly, using the Musculoskeletal Infection Society diagnostic criteria for PJI may miss some cases of MAC PJI. Treatment courses and outcomes are described.
Julian Maamari, Aaron J. Tande, Felix Diehn, Don Bambino Geno Tai, and Elie F. Berbari
J. Bone Joint Infect., 7, 23–32, https://doi.org/10.5194/jbji-7-23-2022, https://doi.org/10.5194/jbji-7-23-2022, 2022
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The yearly incidence of native vertebral osteomyelitis (NVO) is increasing. In 2013 the prevalence of NVO in the USA was 5.4 cases per 100 000. Delays in the diagnosis of NVO remain common, in part due to the insidious nature of the infection and its related symptoms. The mean time between the onset of symptoms to diagnosis of NVO is 45.5 d. We herein review available and novel diagnostic modalities at the disposal of healthcare providers to reach an accurate and timely diagnosis of NVO.
Miao Xian Zhou, Elie F. Berbari, Cory G. Couch, Scott F. Gruwell, and Alan B. Carr
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This was written to outline Mayo Clinic guidelines on prophylactic antibiotics prior to invasive procedures in patients with prosthetic joints. There is an emphasis on maintaining optimal oral health to reduce the risk of infection to minimize the patient’s risk of PJI.
Stephanie L. Grach and Aaron J. Tande
J. Bone Joint Infect., 6, 39–42, https://doi.org/10.5194/jbji-6-39-2020, https://doi.org/10.5194/jbji-6-39-2020, 2020
Cited articles
Alshamsi, F., Belley-Cote, E., Cook, D., Almenawer, S. A., Alqahtani, Z.,
Perri, D., Thabane, L., Al-Omari, A., Lewis, K., Guyatt, G., and Alhazzani,
W.: Efficacy and safety of proton pump inhibitors for stress ulcer
prophylaxis in critically ill patients: a systematic review and
meta-analysis of randomized trials, Crit. Care, 20, 120,
https://doi.org/10.1186/s13054-016-1305-6, 2016.
Azamgarhi, T., Shah, A., and Warren, S.: Clinical Experience of Implementing
Oral Versus Intravenous Antibiotics (OVIVA) in a Specialist Orthopedic
Hospital, Clin. Infect. Dis., 73, e2582–e2588,
https://doi.org/10.1093/cid/ciaa985, 2021.
Babouee Flury, B., Elzi, L., Kolbe, M., Frei, R., Weisser, M., Schären,
S., Widmer, A. F., and Battegay, M.: Is switching to an oral antibiotic
regimen safe after 2 weeks of intravenous treatment for primary bacterial
vertebral osteomyelitis?, BMC Infect. Dis., 14, 226,
https://doi.org/10.1186/1471-2334-14-226, 2014.
Berbari, E. F., Kanj, S. S., Kowalski, T. J., Darouiche, R. O., Widmer, A.
F., Schmitt, S. K., Hendershot, E. F., Holtom, P. D., Huddleston, P. M.,
Petermann, G. W., and Osmon, D. R.: 2015 Infectious Diseases Society of
America (IDSA) Clinical Practice Guidelines for the Diagnosis and Treatment
of Native Vertebral Osteomyelitis in Adultsa, Clin. Infect. Dis., 61,
e26–e46, https://doi.org/10.1093/cid/civ482, 2015.
Bernard, L., Dinh, A,, Ghout, I., Simo, D., Zeller, V., Issartel, B., Le
Moing, V., Belmatoug, N., Lesprit, P., Bru, J.P., Therby, A., Bouhour, D.,
Dénes, E., Debard, A., Chirouze, C., Fèvre, K., Dupon, M., Aegerter,
P., and Mulleman, D.: Duration of Treatment for Spondylodiscitis (DTS) study
group. Antibiotic treatment for 6 weeks versus 12 weeks in patients with
pyogenic vertebral osteomyelitis: an open-label, non-inferiority,
randomised, controlled trial, Lancet, 385, 875–882, https://doi.org/10.1016/S0140-6736(14)61233-2, 2015.
Bettini, N., Girardo, M., Dema, E., and Cervellati, S.: Evaluation of
conservative treatment of non specific spondylodiscitis, Eur. Spine J., 18, 143–150, https://doi.org/10.1007/s00586-009-0979-8, 2009.
Conterno, L. O. and Turchi, M. D.: Antibiotics for treating chronic
osteomyelitis in adults, Cochrane database Syst. Rev., 9, CD004439,
https://doi.org/10.1002/14651858.CD004439.pub3, 2013.
Esmaeilnejad-Ganji, S. M. and Esmaeilnejad-Ganji, S. M. R.: Osteoarticular
manifestations of human brucellosis: A review., World J. Orthop., 10,
54–62, https://doi.org/10.5312/wjo.v10.i2.54, 2019.
Euba, G., Murillo, O., Fernández-Sabé, N., Mascaró, J., Cabo,
J., Pérez, A., Tubau, F., Verdaguer, R., Gudiol, F., and Ariza, J.:
Long-term follow-up trial of oral rifampin-cotrimoxazole combination versus
intravenous cloxacillin in treatment of chronic staphylococcal
osteomyelitis, Antimicrob. Agents Chemother., 53, 2672–2676,
https://doi.org/10.1128/AAC.01504-08, 2009.
Fong, I. W., Ledbetter, W. H., Vandenbroucke, A. C., Simbul, M., and Rahm,
V.: Ciprofloxacin concentrations in bone and muscle after oral dosing,
Antimicrob. Agents Chemother., 29, 405–408,
https://doi.org/10.1128/AAC.29.3.405, 1986.
Ford, I. and Norrie, J.: Pragmatic Trials, N. Engl. J. Med., 375, 454–463,
https://doi.org/10.1056/NEJMra1510059, 2016.
García Del Pozo, E., Collazos, J., Cartón, J. A., Camporro, D., and
Asensi, V.: Bacterial osteomyelitis: microbiological, clinical, therapeutic,
and evolutive characteristics of 344 episodes, Rev. Esp. Quimioter., 31,
217–225, 2018.
Gomis, M.: Oral ofloxacin versus parenteral imipenem-cilastatin in the
treatment of osteomyelitis, Rev. Esp. Quimioter., 12, 244–249, 1999.
Guo, W., Wang, M., Chen, G., Chen, K.-H., Wan, Y., Chen, B., Zou, X., and
Peng, X.: Early surgery with antibiotic medication was effective and
efficient in treating pyogenic spondylodiscitis, BMC Musculoskelet.
Disord., 22, 288, https://doi.org/10.1186/s12891-021-04155-2, 2021.
Guyatt, G., Oxman, A. D., Akl, E. A., Kunz, R., Vist, G., Brozek, J.,
Norris, S., Falck-Ytter, Y., Glasziou, P., DeBeer, H., Jaeschke, R., Rind,
D., Meerpohl, J., Dahm, P., and Schünemann, H. J.: GRADE guidelines: 1.
Introduction-GRADE evidence profiles and summary of findings tables, J.
Clin. Epidemiol., 64, 383–394,
https://doi.org/10.1016/j.jclinepi.2010.04.026, 2011.
Henry, M. W., Miller, A. O., Walsh, T. J., and Brause, B. D.: Fungal
Musculoskeletal Infections, Infect. Dis. Clin. North Am., 31, 353–368,
https://doi.org/10.1016/j.idc.2017.01.006, 2017.
Hogan, J. I., Hurtado, R. M., and Nelson, S. B.: Mycobacterial
Musculoskeletal Infections, Thorac. Surg. Clin., 29, 85–94,
https://doi.org/10.1016/j.thorsurg.2018.09.007, 2019.
Issa, K., Diebo, B. G., Faloon, M., Naziri, Q., Pourtaheri, S., Paulino, C.
B., and Emami, A.: The Epidemiology of Vertebral Osteomyelitis in the United
States From 1998 to 2013, Clin. Spine Surg., 31, E102–E108,
https://doi.org/10.1097/BSD.0000000000000597, 2018.
Iversen, K., Ihlemann, N., Gill, S. U., Madsen, T., Elming, H., Jensen, K.
T., Bruun, N. E., Høfsten, D. E., Fursted, K., Christensen, J. J.,
Schultz, M., Klein, C. F., Fosbøll, E. L., Rosenvinge, F.,
Schønheyder, H. C., Køber, L., Torp-Pedersen, C., Helweg-Larsen, J.,
Tønder, N., Moser, C., and Bundgaard, H.: Partial Oral versus Intravenous
Antibiotic Treatment of Endocarditis, N. Engl. J. Med., 380, 415–424,
https://doi.org/10.1056/NEJMoa1808312, 2019.
Kim, U. J., Bae, J. Y., Kim, S.-E., Kim, C.-J., Kang, S.-J., Jang, H.-C.,
Jung, S. I., Song, K.-H., Kim, E. S., Kim, H. Bin, Park, W. B., Kim, N. J.,
and Park, K.-H.: Comparison of pyogenic postoperative and native vertebral
osteomyelitis, Spine J., 19, 880–887,
https://doi.org/10.1016/j.spinee.2018.11.012, 2019.
Kutscha-Lissberg, F., Hebler, U., Muhr, G., and Köller, M.: Linezolid
penetration into bone and joint tissues infected with methicillin-resistant
staphylococci, Antimicrob. Agents Chemother., 47, 3964–3966,
https://doi.org/10.1128/AAC.47.12.3964-3966.2003, 2003.
Lestin-Bernstein, F., Tietke, M., Briedigkeit, L., and Heese, O.:
Diagnostics and antibiotic therapy for spondylodiscitis, J. Med. Microbiol.,
67, 757–768, https://doi.org/10.1099/jmm.0.000703, 2018.
Li, H. K., Scarborough, M., Zambellas, R., Cooper, C., Rombach, I., Walker,
A. S., Lipsky, B. A., Briggs, A., Seaton, A., Atkins, B., Woodhouse, A.,
Berendt, A., Byren, I., Angus, B., Pandit, H., Stubbs, D., McNally, M.,
Thwaites, G., and Bejon, P.: Oral versus intravenous antibiotic treatment
for bone and joint infections (OVIVA): study protocol for a randomised
controlled trial, Trials, 16, 583,
https://doi.org/10.1186/s13063-015-1098-y, 2015.
Li, H.-K., Rombach, I., Zambellas, R., Walker, A. S., McNally, M. A.,
Atkins, B. L., Lipsky, B. A., Hughes, H. C., Bose, D., Kümin, M.,
Scarborough, C., Matthews, P. C., Brent, A. J., Lomas, J., Gundle, R.,
Rogers, M., Taylor, A., Angus, B., Byren, I., Berendt, A. R., Warren, S.,
Fitzgerald, F. E., Mack, D. J. F., Hopkins, S., Folb, J., Reynolds, H. E.,
Moore, E., Marshall, J., Jenkins, N., Moran, C. E., Woodhouse, A. F.,
Stafford, S., Seaton, R. A., Vallance, C., Hemsley, C. J., Bisnauthsing, K.,
Sandoe, J. A. T., Aggarwal, I., Ellis, S. C., Bunn, D. J., Sutherland, R.
K., Barlow, G., Cooper, C., Geue, C., McMeekin, N., Briggs, A. H., Sendi,
P., Khatamzas, E., Wangrangsimakul, T., Wong, T. H. N., Barrett, L. K.,
Alvand, A., Old, C. F., Bostock, J., Paul, J., Cooke, G., Thwaites, G. E.,
Bejon, P., and Scarborough, M.: Oral versus Intravenous Antibiotics for Bone
and Joint Infection, N. Engl. J. Med., 380, 425–436,
https://doi.org/10.1056/NEJMoa1710926, 2019.
Lin, J. S., Murad, M. H., Leas, B., Treadwell, J. R., Chou, R., Ivlev, I.,
and Kansagara, D.: A Narrative Review and Proposed Framework for Using
Health System Data with Systematic Reviews to Support Decision-making, J.
Gen. Intern. Med., 35, 1830–1835,
https://doi.org/10.1007/s11606-020-05783-5, 2020.
Lin, L. and Xu, C.: Arcsine-based transformations for meta-analysis of
proportions: Pros, cons, and alternatives, Heal. Sci. Reports, 3, e178,
https://doi.org/10.1002/hsr2.178, 2020.
Livorsi, D. J., Daver, N. G., Atmar, R. L., Shelburne, S. A., White, A. C.,
and Musher, D. M.: Outcomes of treatment for hematogenous Staphylococcus
aureus vertebral osteomyelitis in the MRSA ERA, J. Infect., 57, 128–131,
https://doi.org/10.1016/j.jinf.2008.04.012, 2008.
Locke, T., Kell, M. E., Bhattacharyya, D., Cole, A. A., and Chapman, A. L.
N.: Spontaneous methicillin-sensitive Staphylococcus aureus
spondylodiscitis-Short course antibiotic therapy may be adequate: Evidence
from a single centre cohort, J. Infect. Public Health, 7, 44–49,
https://doi.org/10.1016/j.jiph.2013.08.001, 2014.
Mader, J.: Oral ciprofloxacin compared with standard parenteral antibiotic
therapy for chronic osteomyelitis in adultsNo Title, J. Bone Jt. Surg., 72,
104–110, 1990.
Mogle, B. T., Beccari, M. V, Steele, J. M., Fazili, T., and Kufel, W. D.:
Clinical considerations for oral beta-lactams as step-down therapy for
Enterobacteriaceae bloodstream infections, Expert Opin. Pharmacother., 20,
903–907, https://doi.org/10.1080/14656566.2019.1594774, 2019.
Murad, M. H., Sultan, S., Haffar, S., and Bazerbachi, F.: Methodological
quality and synthesis of case series and case reports, BMJ evidence-based
Med., 23, 60–63, https://doi.org/10.1136/bmjebm-2017-110853, 2018.
Nathoo, N., Caris, E. C., Wiener, J. A., and Mendel, E.: History of the
Vertebral Venous Plexus and the Significant Contributions of Breschet and
Batson, Neurosurgery, 69, 1007–1014,
https://doi.org/10.1227/NEU.0b013e3182274865, 2011.
Oh, W. S., Moon, C., Chung, J. W., Choo, E. J., Kwak, Y. G., Kim, S. H.,
Ryu, S. Y., Park, S. Y., and Kim, B. N.: Antibiotic Treatment of Vertebral
Osteomyelitis caused by Methicillin-Susceptible Staphylococcus aureus: A
Focus on the Use of Oral β-lactams, Infect. Chemother., 51,
284–294, https://doi.org/10.3947/ic.2019.51.3.284, 2019.
Park, K.-H., Cho, O.-H., Lee, J. H., Park, J. S., Ryu, K. N., Park, S. Y.,
Lee, Y.-M., Chong, Y. P., Kim, S.-H., Lee, S.-O., Choi, S.-H., Bae, I.-G.,
Kim, Y. S., Woo, J. H., and Lee, M. S.: Optimal Duration of Antibiotic
Therapy in Patients With Hematogenous Vertebral Osteomyelitis at Low Risk
and High Risk of Recurrence, Clin. Infect. Dis., 62, 1262–1269,
https://doi.org/10.1093/cid/ciw098, 2016.
Russo, A., Ceccarelli, G., Bellelli, V., Bianchi, L., Marincola Cattaneo,
F., Gregori, F., Palmarini, V., Marotta, N., Landi, A., Cuzzolino, A.,
Stefanini, M., Aureli, A., Mastroianni, C. M., Venditti, M., d'Ettorre, G.,
and Sabetta, F.: Efficacy of Daptomycin-Containing Regimen for Treatment of
Staphylococcal or Enterococcal Vertebral Osteomyelitis: A Prospective
Clinical Experience, Antibiot. (Basel, Switzerland), 9, 889,
https://doi.org/10.3390/antibiotics9120889, 2020.
Sakeni, R. A. and Al-Nimer, M. S. M.: Infectious discitis in adults: 9 years
experience from Al-Yarmouk Teaching Hospital in Baghdad, Iraq, Int. J.
Rheum. Dis., 11, 175–180, https://doi.org/10.1111/j.1756-185X.2008.00354.x,
2008.
Spellberg, B. and Lipsky, B. A.: Systemic antibiotic therapy for chronic
osteomyelitis in adults, Clin. Infect. Dis., 54, 393–407,
https://doi.org/10.1093/cid/cir842, 2012.
Spellberg, B., Chambers, H. F., Musher, D. M., Walsh, T. L., and Bayer, A.
S.: Evaluation of a Paradigm Shift From Intravenous Antibiotics to Oral
Step-Down Therapy for the Treatment of Infective Endocarditis, JAMA Intern.
Med., 180, 769, https://doi.org/10.1001/jamainternmed.2020.0555, 2020.
Spellberg, B., Aggrey, G., Brennan, M. B., Footer, B., Forrest, G.,
Hamilton, F., Minejima, E., Moore, J., Ahn, J., Angarone, M., Centor, R. M.,
Cherabuddi, K., Curran, J., Davar, K., Davis, J., Dong, M. Q., Ghanem, B.,
Hutcheon, D., Jent, P., Kang, M., Lee, R., McDonald, E. G., Morris, A. M.,
Reece, R., Schwartz, I. S., So, M., Tong, S., Tucker, C., Wald-Dickler, N.,
Weinstein, E. J., Williams, R., Yen, C., Zhou, S., Lee, T. C., Baden, R.,
Bedard-Dallare, S., Beltran, C., Blythe, M., Brass, E., Chi, S., Coffey, C.,
Cowart, M., Diaz, A., Dwyer, J., Jordan Villegas, A., Khan, E., Martinez,
J., Mattappallil, A., Meshkaty, N., Patel, A., Pullen, M., Rajan, S.,
Saxinger, L., Tirupathi, R., Trivedi, J., Vilchez-Molina, G., Werge, D., and
Werge, D.: Use of Novel Strategies to Develop Guidelines for Management of
Pyogenic Osteomyelitis in Adults, JAMA Netw. Open, 5, e2211321,
https://doi.org/10.1001/jamanetworkopen.2022.11321, 2022.
Stang, A.: Critical evaluation of the Newcastle-Ottawa scale for the
assessment of the quality of nonrandomized studies in meta-analyses, Eur.
J. Epidemiol., 25, 603–605, https://doi.org/10.1007/s10654-010-9491-z, 2010.
Sterne, J. A. C., Savović, J., Page, M. J., Elbers, R. G., Blencowe, N.
S., Boutron, I., Cates, C. J., Cheng, H.-Y., Corbett, M. S., Eldridge, S.
M., Emberson, J. R., Hernán, M. A., Hopewell, S., Hróbjartsson, A.,
Junqueira, D. R., Jüni, P., Kirkham, J. J., Lasserson, T., Li, T.,
McAleenan, A., Reeves, B. C., Shepperd, S., Shrier, I., Stewart, L. A.,
Tilling, K., White, I. R., Whiting, P. F., and Higgins, J. P. T.: RoB 2: a
revised tool for assessing risk of bias in randomised trials, BMJ, 366,
l4898, https://doi.org/10.1136/bmj.l4898, 2019.
Wald-Dickler, N., Holtom, P. D., Phillips, M. C., Centor, R. M., Lee, R. A.,
Baden, R., and Spellberg, B.: Oral Is the New IV. Challenging Decades of
Blood and Bone Infection Dogma: A Systematic Review, Am. J. Med., 135,
369–379.e1, https://doi.org/10.1016/j.amjmed.2021.10.007, 2022.
Wallace, B. C., Dahabreh, I. J., Trikalinos, T. A., Lau, J., Trow, P., and
Schmid, C. H.: Closing the Gap between Methodologists and End-Users: R as a
Computational Back-End, J. Stat. Softw., 49, 1–15,
https://doi.org/10.18637/jss.v049.i05, 2012.
Zimmerli, W.: Clinical practice. Vertebral osteomyelitis, N. Engl. J. Med.,
362, 1022–1029, https://doi.org/10.1056/NEJMcp0910753, 2010.
Short summary
Despite a growing interest in oral therapy for native vertebral osteomyelitis, there is no evidence to recommend oral or parenteral therapy. From our single-center experience combined with a systematic review and a meta-analysis of the available literature, there is insufficient evidence to conclude that there is a difference in proportion of failure and relapse between an early switch to oral antibiotics and prolonged parenteral therapy. Further studies are needed to increase the evidence.
Despite a growing interest in oral therapy for native vertebral osteomyelitis, there is no...
