Articles | Volume 7, issue 5
https://doi.org/10.5194/jbji-7-191-2022
https://doi.org/10.5194/jbji-7-191-2022
Review
 | 
19 Sep 2022
Review |  | 19 Sep 2022

Intravenous antibiotic duration in the treatment of prosthetic joint infection: systematic review and meta-analysis

Nour Bouji, Sijin Wen, and Matthew J. Dietz

Related subject area

Subject: Prosthesis-related infections | Topic: Antibiotic therapy
Dosing and treatment duration of suppressive antimicrobial therapy in orthopedic implant infections: a cohort study
Jaap L. J. Hanssen, Robert J. P. van der Wal, Henrica M. J. van der Linden, Joffrey van Prehn, Henk Scheper, and Mark G. J. de Boer
J. Bone Joint Infect., 9, 149–159, https://doi.org/10.5194/jbji-9-149-2024,https://doi.org/10.5194/jbji-9-149-2024, 2024
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No differences in outcomes with stopping or continuing antibiotic suppression in periprosthetic joint infections
Daisuke Furukawa, Megan Dunning, Sa Shen, Amy Chang, Jenny Aronson, Derek F. Amanatullah, Gina A. Suh, and Shanthi Kappagoda
J. Bone Joint Infect., 9, 143–148, https://doi.org/10.5194/jbji-9-143-2024,https://doi.org/10.5194/jbji-9-143-2024, 2024
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Antibiotic prophylaxis before tissue biopsy has no effect on culture results in presumed aseptic revision total hip arthroplasty
Jesse D. De Groot, Roy G. B. Brokelman, Bas L. Fransen, Tim U. Jiya, and Dean F. M. Pakvis
J. Bone Joint Infect., 9, 67–74, https://doi.org/10.5194/jbji-9-67-2024,https://doi.org/10.5194/jbji-9-67-2024, 2024
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Treatment of Neisseria meningitidis prosthetic joint infections with short-course antibiotics: three cases and a literature review
Sarah Browning, Harry N. Walker, Thomas Ryan, Robert Pickles, Michael Loftus, Jason A. Trubiano, Andrew Hardidge, and Joshua S. Davis
J. Bone Joint Infect., 6, 33–37, https://doi.org/10.5194/jbji-6-33-2020,https://doi.org/10.5194/jbji-6-33-2020, 2020
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Cited articles

Ascione, T., Pagliano, P., Balato, G., Mariconda, M., Rotondo, R., and Esposito, S.: Oral Therapy, Microbiological Findings, and Comorbidity Influence the Outcome of Prosthetic Joint Infections Undergoing 2-Stage Exchange, J. Arthroplasty, 32, 2239–2243, https://doi.org/10.1016/j.arth.2017.02.057, 2017. 
Bernard, L., Legout, L., Zürcher-Pfund, L., Stern, R., Rohner, P., Peter, R., Assal, M., Lew, D., Hoffmeyer, P., and Uçkay, I.: Six weeks of antibiotic treatment is sufficient following surgery for septic arthroplasty, J. Infect., 61, 125–132, https://doi.org/10.1016/j.jinf.2010.05.005, 2010. 
Boclé, H., Lavigne, J.-P., Cellier, N., Crouzet, J., Kouyoumdjian, P., Sotto, A., and Loubet, P.: Effectiveness of early switching from intravenous to oral antibiotic therapy in Staphylococcus aureus prosthetic bone and joint or orthopedic metalware-associated infections, BMC Musculoskelet. Disord., 22, 1–7, 2021. 
Bozic, K. J. and Ries, M. D.: The Impact of Infection After Total Hip Arthroplasty on Hospital and Surgeon Resource Utilization, J. Bone Joint Surg. Am., 87, 1746–1751, https://doi.org/10.2106/JBJS.D.02937, 2005. 
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Short summary
Long antibiotic courses, including IV and oral administrations, are utilized in prosthetic joint infection (PJI) treatment. Most researchers focus on a shorter duration of the overall antibiotic course for the treatment of PJI; however, this is the first systematic review and meta-analysis to emphasize the IV component of the antibiotic course. The focus on IV treatment only is due to the burden associated with it and its prolonged utilization within the US without much evidence of practice.