Articles | Volume 7, issue 5
19 Sep 2022
Review |  | 19 Sep 2022

Intravenous antibiotic duration in the treatment of prosthetic joint infection: systematic review and meta-analysis

Nour Bouji, Sijin Wen, and Matthew J. Dietz

Related subject area

Subject: Prosthesis-related infections | Topic: Antibiotic therapy
Treatment of Neisseria meningitidis prosthetic joint infections with short-course antibiotics: three cases and a literature review
Sarah Browning, Harry N. Walker, Thomas Ryan, Robert Pickles, Michael Loftus, Jason A. Trubiano, Andrew Hardidge, and Joshua S. Davis
J. Bone Joint Infect., 6, 33–37,,, 2020
Short summary

Cited articles

Ascione, T., Pagliano, P., Balato, G., Mariconda, M., Rotondo, R., and Esposito, S.: Oral Therapy, Microbiological Findings, and Comorbidity Influence the Outcome of Prosthetic Joint Infections Undergoing 2-Stage Exchange, J. Arthroplasty, 32, 2239–2243,, 2017. 
Bernard, L., Legout, L., Zürcher-Pfund, L., Stern, R., Rohner, P., Peter, R., Assal, M., Lew, D., Hoffmeyer, P., and Uçkay, I.: Six weeks of antibiotic treatment is sufficient following surgery for septic arthroplasty, J. Infect., 61, 125–132,, 2010. 
Boclé, H., Lavigne, J.-P., Cellier, N., Crouzet, J., Kouyoumdjian, P., Sotto, A., and Loubet, P.: Effectiveness of early switching from intravenous to oral antibiotic therapy in Staphylococcus aureus prosthetic bone and joint or orthopedic metalware-associated infections, BMC Musculoskelet. Disord., 22, 1–7, 2021. 
Bozic, K. J. and Ries, M. D.: The Impact of Infection After Total Hip Arthroplasty on Hospital and Surgeon Resource Utilization, J. Bone Joint Surg. Am., 87, 1746–1751,, 2005. 
Short summary
Long antibiotic courses, including IV and oral administrations, are utilized in prosthetic joint infection (PJI) treatment. Most researchers focus on a shorter duration of the overall antibiotic course for the treatment of PJI; however, this is the first systematic review and meta-analysis to emphasize the IV component of the antibiotic course. The focus on IV treatment only is due to the burden associated with it and its prolonged utilization within the US without much evidence of practice.