Journal of Bone and Joint Infection
Journal of Bone and Joint Infection
JBJI
Articles | Volume 7, issue 1
Articles | Volume 7, issue 1
https://doi.org/10.5194/jbji-7-1-2022
© Author(s) 2022. This work is distributed under
the Creative Commons Attribution 4.0 License.
https://doi.org/10.5194/jbji-7-1-2022
© Author(s) 2022. This work is distributed under
the Creative Commons Attribution 4.0 License.
Articles | Volume 7, issue 1
Original full-length article
 | 
06 Jan 2022
Original full-length article |  | 06 Jan 2022

Nuclear imaging does not have clear added value in patients with low a priori chance of periprosthetic joint infection. A retrospective single-center experience

Karsten D. Ottink, Stefan J. Gelderman, Marjan Wouthuyzen-Bakker, Joris J. W. Ploegmakers, Andor W. J. M. Glaudemans, and Paul C. Jutte

Related authors

Risk factors for treatment failure in late acute periprosthetic joint infection in patients with rheumatoid arthritis treated with surgical debridement – a case-control study
Hendrika M. Schenk, Marine Sebillotte, Jose Lomas, Adrian Taylor, Eva Benavent, Oscar Murillo, Marta Fernandez-Sampedro, Kaisa Huotari, Craig Aboltins, Rihard Trebse, Alex Soriano, Marjan Wouthuyzen-Bakker, and on behalf of the ESCMID Study Group on Implant Associated Infections (ESGIAI)
J. Bone Joint Infect., 10, 217–224, https://doi.org/10.5194/jbji-10-217-2025,https://doi.org/10.5194/jbji-10-217-2025, 2025
Short summary
Debridement, antimicrobial therapy, and implant retention (DAIR) as curative surgical strategy for acute periprosthetic hip and knee infections: a summary of the position paper from the European Bone & Joint Infection Society (EBJIS)
Irene K. Sigmund, Marjan Wouthuyzen-Bakker, Tristan Ferry, Willem-Jan Metsemakers, Martin Clauss, Alex Soriano, Rihard Trebse, and Ricardo Sousa
J. Bone Joint Infect., 10, 139–142, https://doi.org/10.5194/jbji-10-139-2025,https://doi.org/10.5194/jbji-10-139-2025, 2025
Short summary
Debridement, antimicrobial therapy, and implant retention (DAIR) as curative strategy for acute periprosthetic hip and knee infections: a position paper of the European Bone & Joint Infection Society (EBJIS)
Irene K. Sigmund, Tristan Ferry, Ricardo Sousa, Alex Soriano, Willem-Jan Metsemakers, Martin Clauss, Rihard Trebse, and Marjan Wouthuyzen-Bakker
J. Bone Joint Infect., 10, 101–138, https://doi.org/10.5194/jbji-10-101-2025,https://doi.org/10.5194/jbji-10-101-2025, 2025
Short summary
Postoperative antibiotic treatment does not lower re-revision rate in presumed aseptic hip and knee revision arthroplasties with unexpected positive intraoperative cultures – a matched cohort study
Sebastian Simon, Marjan Wouthuyzen-Bakker, Susana Gardete Hartmann, Jennyfer A. Mitterer, Sujeesh Sebastian, Stephanie Huber, Bernhard J. H. Frank, and Jochen G. Hofstaetter
J. Bone Joint Infect., 10, 51–59, https://doi.org/10.5194/jbji-10-51-2025,https://doi.org/10.5194/jbji-10-51-2025, 2025
Short summary
Predicting periprosthetic joint infection: external validation of preoperative prediction models
Seung-Jae Yoon, Paul C. Jutte, Alex Soriano, Ricardo Sousa, Wierd P. Zijlstra, and Marjan Wouthuyzen-Bakker
J. Bone Joint Infect., 9, 231–239, https://doi.org/10.5194/jbji-9-231-2024,https://doi.org/10.5194/jbji-9-231-2024, 2024
Short summary
More articles (7)

Related subject area

Subject: Prosthesis-related infections | Topic: Other
Synovial glucose and serum-to-synovial-glucose ratio perform better than other biomarkers for the diagnosis of acute postoperative prosthetic knee infection
Marta Sabater-Martos, Oscar Garcia, Laia Boadas, Laura Morata, Alex Soriano, and Juan Carlos Martínez-Pastor
J. Bone Joint Infect., 10, 41–49, https://doi.org/10.5194/jbji-10-41-2025,https://doi.org/10.5194/jbji-10-41-2025, 2025
Short summary
Changing the definition of treatment success alters treatment outcomes in periprosthetic joint infection: a systematic review and meta-analysis
Eytan M. Debbi, Tyler Khilnani, Ioannis Gkiatas, Yu-Fen Chiu, Andy O. Miller, Michael W. Henry, and Alberto V. Carli
J. Bone Joint Infect., 9, 127–136, https://doi.org/10.5194/jbji-9-127-2024,https://doi.org/10.5194/jbji-9-127-2024, 2024
Short summary
Diagnostic cutoff values of synovial fluid biomarkers for acute postoperative prosthetic joint infection: a systematic review and meta-analysis
Marta Sabater-Martos, Marc Ferrer, Laura Morata, Alex Soriano, and Juan Carlos Martínez-Pastor
J. Bone Joint Infect., 9, 17–26, https://doi.org/10.5194/jbji-9-17-2024,https://doi.org/10.5194/jbji-9-17-2024, 2024
Short summary
Is ultrasound-guided hip aspiration more successful than fluoroscopic-guided aspiration in diagnosing prosthetic joint infection?
Emily A. Treu, Daniel M. Cushman, John C. Wheelwright, Brenna E. Blackburn, Masaru Teramoto, and Michael J. Archibeck
J. Bone Joint Infect., 8, 151–163, https://doi.org/10.5194/jbji-8-151-2023,https://doi.org/10.5194/jbji-8-151-2023, 2023
Short summary
Simple and inexpensive synovial fluid biomarkers for the diagnosis of prosthetic joint infection according to the new EBJIS definition
Sara Elisa Diniz, Ana Ribau, André Vinha, José Carlos Oliveira, Miguel Araújo Abreu, and Ricardo Sousa
J. Bone Joint Infect., 8, 109–118, https://doi.org/10.5194/jbji-8-109-2023,https://doi.org/10.5194/jbji-8-109-2023, 2023
Short summary
More articles (3)

Cited articles

Auletta, S., Riolo, D., Varani, M., Lauri, C., Galli, F., and Signore, A.: Labelling and Clinical Performance of Human Leukocytes Labelled with 99mTc-HMPAO Using Leukokit® with Gelofusine versus Leukokit® with HES as Sedimentation Agent, Contrast Media Mol. I., 2019, 4368342, https://doi.org/10.1155/2019/4368342, 2019. 
Blanc, P., Bonnet, E., Giordano, G., Monteil, J., Salabert, A., and Payoux, P.: The use of labelled leucocyte scintigraphy to evaluate chronic periprosthetic joint infections: a retrospective multicentre study on 168 patients, Eur. J. Clin. Microbiol. Infect. Dis., 38, 1625–1631, https://doi.org/10.1007/s10096-019-03587-y, 2019. 
Bozhkova, S., Suardi, V., Sharma, H. K., Tsuchiya, H., Del Sel, H., Hafez, M. A., Benzakour, T., Drago, L., and Romanò, C. L.: The W.A.I.O.T. Definition of Peri-Prosthetic Joint Infection: A Multi-center, Retrospective Validation Study, J. Clin. Med., 9, 1965, https://doi.org/10.3390/jcm9061965, 2020. 
de Vries, E. F. J., Roca, M., Jamar, F., Israel, O., and Signore, A.: Guidelines for the labelling of leucocytes with (99m)Tc-HMPAO. Inflammation/Infection Taskgroup of the European Association of Nuclear Medicine, Eur. J. Nucl. Med. Mol. Imaging, 37, 842–848, https://doi.org/10.1007/s00259-010-1394-4, 2010. 
Diaz-Ledezma, C., Lamberton, C., Lichstein, P., and Parvizi, J.: Diagnosis of Periprosthetic Joint Infection: The Role of Nuclear Medicine May Be Overestimated, J. Arthroplasty, 30, 1044–1049, https://doi.org/10.1016/j.arth.2015.01.008, 2015. 
More articles (43)
Download
Short summary
A low-grade periprosthetic joint infection (PJI) may be difficult to diagnose, and nuclear imaging could help in the diagnosis. However, its diagnostic value is unclear. We retrospectively evaluated this diagnostic value. We conclude that in patients presenting with nonspecific symptoms and a low a priori chance of PJI based on clinical evaluation, nuclear imaging is of no clear added value in diagnosing a PJI.
Read more
Share