Articles | Volume 7, issue 1
J. Bone Joint Infect., 7, 1–9, 2022
J. Bone Joint Infect., 7, 1–9, 2022

Original full-length article 06 Jan 2022

Original full-length article | 06 Jan 2022

Nuclear imaging does not have clear added value in patients with low a priori chance of periprosthetic joint infection. A retrospective single-center experience

Karsten D. Ottink et al.

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Cited articles

Auletta, S., Riolo, D., Varani, M., Lauri, C., Galli, F., and Signore, A.: Labelling and Clinical Performance of Human Leukocytes Labelled with 99mTc-HMPAO Using Leukokit® with Gelofusine versus Leukokit® with HES as Sedimentation Agent, Contrast Media Mol. I., 2019, 4368342,, 2019. 
Blanc, P., Bonnet, E., Giordano, G., Monteil, J., Salabert, A., and Payoux, P.: The use of labelled leucocyte scintigraphy to evaluate chronic periprosthetic joint infections: a retrospective multicentre study on 168 patients, Eur. J. Clin. Microbiol. Infect. Dis., 38, 1625–1631,, 2019. 
Bozhkova, S., Suardi, V., Sharma, H. K., Tsuchiya, H., Del Sel, H., Hafez, M. A., Benzakour, T., Drago, L., and Romanò, C. L.: The W.A.I.O.T. Definition of Peri-Prosthetic Joint Infection: A Multi-center, Retrospective Validation Study, J. Clin. Med., 9, 1965,, 2020. 
de Vries, E. F. J., Roca, M., Jamar, F., Israel, O., and Signore, A.: Guidelines for the labelling of leucocytes with (99m)Tc-HMPAO. Inflammation/Infection Taskgroup of the European Association of Nuclear Medicine, Eur. J. Nucl. Med. Mol. Imaging, 37, 842–848,, 2010. 
Diaz-Ledezma, C., Lamberton, C., Lichstein, P., and Parvizi, J.: Diagnosis of Periprosthetic Joint Infection: The Role of Nuclear Medicine May Be Overestimated, J. Arthroplasty, 30, 1044–1049,, 2015. 
Short summary
A low-grade periprosthetic joint infection (PJI) may be difficult to diagnose, and nuclear imaging could help in the diagnosis. However, its diagnostic value is unclear. We retrospectively evaluated this diagnostic value. We conclude that in patients presenting with nonspecific symptoms and a low a priori chance of PJI based on clinical evaluation, nuclear imaging is of no clear added value in diagnosing a PJI.