The <i>Staphylococcus aureus</i> toxin–antitoxin system YefM–YoeB is associated with antibiotic tolerance and extracellular dependent biofilm formation

Qi, Xinyu; Brothers, Kimberly M.; Ma, Dongzhu; Mandell, Jonathan B.; Donegan, Niles P.; Cheung, Ambrose L.; Richardson, Anthony R.; Urish, Kenneth L.

doi:10.5194/jbji-6-241-2021

Articles | Volume 6, issue 7

https://doi.org/10.5194/jbji-6-241-2021

© Author(s) 2021. This work is distributed under
the Creative Commons Attribution 4.0 License.

https://doi.org/10.5194/jbji-6-241-2021

© Author(s) 2021. This work is distributed under
the Creative Commons Attribution 4.0 License.

Articles | Volume 6, issue 7

Original full-length article

|

02 Jul 2021

Original full-length article |

| 02 Jul 2021

The Staphylococcus aureus toxin–antitoxin system YefM–YoeB is associated with antibiotic tolerance and extracellular dependent biofilm formation

Xinyu Qi, Kimberly M. Brothers, Dongzhu Ma, Jonathan B. Mandell, Niles P. Donegan, Ambrose L. Cheung, Anthony R. Richardson, and Kenneth L. Urish

Related authors

The proportion of chronic periprosthetic joint infection patients with Candida isolates

Samuelson E. Osifo, Adrian Santana, Michael F. Shannon, Victoria R. Wong, Caroline F. Tyndall, Christian Cisneros, Niosha Parvizi, Brian A. Klatt, Johannes F. Plate, Nicolas S. Piuzzi, and Kenneth L. Urish

J. Bone Joint Infect., 11, 31–41, https://doi.org/10.5194/jbji-11-31-2026,https://doi.org/10.5194/jbji-11-31-2026, 2026

Short summary

No difference in failure between static, articulating, and prosthetic low-friction spacers for periprosthetic joint infection of total knee arthroplasty

Michael F. Shannon, Timothy Edwards, Timothy Maurer, Andrew J. Frear, Victoria R. Wong, Shaan Sadhwani, Clair Smith, Anthony Kamson, Brian Omslaer, Christian Cisneros, Andrew Gordon, Akeem Williams, Neel B. Shah, and Kenneth L. Urish

J. Bone Joint Infect., 10, 243–253, https://doi.org/10.5194/jbji-10-243-2025,https://doi.org/10.5194/jbji-10-243-2025, 2025

Short summary

Type of acute periprosthetic joint infection may not affect failure of debridement, antibiotics, and implant retention after total knee arthroplasty

Andrew J. Frear, Michael F. Shannon, Shaan Sadhwani, Anthony O. Kamson, Clair Smith, Charity G. Patterson, Victoria R. Wong, Frank Johannes Plate, and Kenneth L. Urish

J. Bone Joint Infect., 10, 225–235, https://doi.org/10.5194/jbji-10-225-2025,https://doi.org/10.5194/jbji-10-225-2025, 2025

Short summary

Cited articles

Bakar, F. A., Yeo, C. C., and Harikrishna, J. A.: Expression of the Streptococcus pneumoniae yoeB chromosomal toxin gene causes cell death in the model plant Arabidopsis thaliana, BMC Biotechnol., 15, 26, https://doi.org/10.1186/s12896-015-0138-8, 2015.

Biau, D. J., Larousserie, F., Thevenin, F., Piperno-Neumann, S., and Anract, P.: Results of 32 allograft-prosthesis composite reconstructions of the proximal femur, Clin. Orthop. Relat. Res., 468, 834–845, https://doi.org/10.1007/s11999-009-1132-z, 2010.

Cerca, N., Jefferson, K. K., Oliveira, R., Pier, G. B., and Azeredo, J.: Comparative antibody-mediated phagocytosis of Staphylococcus epidermidis cells grown in a biofilm or in the planktonic state, Infect. Immun., 74, 4849–4855, https://doi.org/10.1128/IAI.00230-06, 2006.

Chan, W. T., Moreno-Cordoba, I., Yeo, C. C., and Espinosa, M.: Toxin-antitoxin genes of the Gram-positive pathogen Streptococcus pneumoniae: so few and yet so many, Microbiol. Mol. Biol. Rev., 76, 773–791, https://doi.org/10.1128/MMBR.00030-12, 2012.

Chan, W. T., Domenech, M., Moreno-Cordoba, I., Navarro-Martinez, V., Nieto, C., Moscoso, M., Garcia, E., and Espinosa, M.: The Streptococcus pneumoniae yefM-yoeB and relBE Toxin-Antitoxin Operons Participate in Oxidative Stress and Biofilm Formation, Toxins (Basel), 10, 1–15, https://doi.org/10.3390/toxins10090378, 2018.