Journal of Bone and Joint Infection
Journal of Bone and Joint Infection
JBJI
Articles | Volume 6, issue 7
Articles | Volume 6, issue 7
https://doi.org/10.5194/jbji-6-241-2021
© Author(s) 2021. This work is distributed under
the Creative Commons Attribution 4.0 License.
https://doi.org/10.5194/jbji-6-241-2021
© Author(s) 2021. This work is distributed under
the Creative Commons Attribution 4.0 License.
Articles | Volume 6, issue 7
Original full-length article
 | 
02 Jul 2021
Original full-length article |  | 02 Jul 2021

The Staphylococcus aureus toxin–antitoxin system YefM–YoeB is associated with antibiotic tolerance and extracellular dependent biofilm formation

Xinyu Qi, Kimberly M. Brothers, Dongzhu Ma, Jonathan B. Mandell, Niles P. Donegan, Ambrose L. Cheung, Anthony R. Richardson, and Kenneth L. Urish

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Short summary
Periprosthetic joint infection (PJI) is one of the most challenging complications following total joint arthroplasty. PJI infections are primarily caused by antibiotic-tolerant biofilms on the surface of the implant. Bacterial toxin antitoxin systems are believed to play a critical role in biofilm antibiotic tolerance and resistance. The objective of this study was to identify the role of the S. aureus toxin YoeB in biofilm formation, antibiotic susceptibility, and virulence.
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