Articles | Volume 11, issue 5
https://doi.org/10.5194/jbji-11-569-2026
https://doi.org/10.5194/jbji-11-569-2026
Review
 | 
14 Sep 2026
Review |  | 14 Sep 2026

Investigating long-term quality of life and depressive symptoms following fracture-related infection: a systematic review with meta-analysis of heterogeneous evidence

Johann Alexander Betker, Nike Walter, Markus Rupp, Susanne Baertl, and Volker Alt

Model code and software

Data_Review_FRI_Results.xlsx and Systematic_Review_FRI.R Johann Betker https://osf.io/9qzds/overview?view_only=16b51194fc3c4f8ea5698172f119a574

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Short summary
An infected bone fracture can lead to long-lasting problems with movement, daily function, and mental well-being. A review of 15 studies found that physical recovery often stayed below normal even after 1 year or more. Overall mental quality of life seemed stable, but other tests showed signs of ongoing depression. The evidence was mixed and limited, therefore better long-term studies and regular psychological screening are needed.
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