Journal of Bone and Joint Infection
Journal of Bone and Joint Infection
JBJI
Articles | Volume 11, issue 4
Articles | Volume 11, issue 4
https://doi.org/10.5194/jbji-11-535-2026
© Author(s) 2026. This work is distributed under
the Creative Commons Attribution 4.0 License.
https://doi.org/10.5194/jbji-11-535-2026
© Author(s) 2026. This work is distributed under
the Creative Commons Attribution 4.0 License.
Articles | Volume 11, issue 4
Original full-length article
 | 
25 Aug 2026
Original full-length article |  | 25 Aug 2026

Feasibility of a rat femoral-defect model for immediate perioperative and delayed post-implantation implant-associated bone infections

Pardis Keikhosravani, Michiel Croes, Nada Ristya Rahmani, Flurina Stabuli, Leonardo Cecotto, H. Charls Vogely, Bart C. H. van der Wal, Marianne Koolen, Debby Gawlitta, Harrie Weinans, Azin Khodaei, and Saber Amin Yavari

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Short summary
This study delivers a practical rat model for both early and delayed implant‑site infections. We show which bacterial doses and states produce consistent infections at each time point, creating a dependable platform to evaluate new materials and treatments that prevent or clear implant infections. 
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