Articles | Volume 11, issue 4
https://doi.org/10.5194/jbji-11-535-2026
© Author(s) 2026. This work is distributed under
the Creative Commons Attribution 4.0 License.
the Creative Commons Attribution 4.0 License.
https://doi.org/10.5194/jbji-11-535-2026
© Author(s) 2026. This work is distributed under
the Creative Commons Attribution 4.0 License.
the Creative Commons Attribution 4.0 License.
Original full-length article
| 
25 Aug 2026
Original full-length article |
| 25 Aug 2026
| 25 Aug 2026
Feasibility of a rat femoral-defect model for immediate perioperative and delayed post-implantation implant-associated bone infections
Pardis Keikhosravani
Department of Orthopedics, University Medical Center Utrecht, Utrecht 3508GA, the Netherlands
Michiel Croes
Department of Orthopedics, University Medical Center Utrecht, Utrecht 3508GA, the Netherlands
Nada Ristya Rahmani
Department of Orthopedics, University Medical Center Utrecht, Utrecht 3508GA, the Netherlands
Flurina Stabuli
Department of Maxillofacial Surgery, University Medical Center Utrecht, Utrecht 3508GA, the Netherlands
Leonardo Cecotto
Department of Orthopedics, University Medical Center Utrecht, Utrecht 3508GA, the Netherlands
H. Charls Vogely
Department of Orthopedics, University Medical Center Utrecht, Utrecht 3508GA, the Netherlands
Bart C. H. van der Wal
Department of Orthopedics, University Medical Center Utrecht, Utrecht 3508GA, the Netherlands
Marianne Koolen
Department of Orthopedics, University Medical Center Utrecht, Utrecht 3508GA, the Netherlands
Debby Gawlitta
Department of Maxillofacial Surgery, University Medical Center Utrecht, Utrecht 3508GA, the Netherlands
Harrie Weinans
CORRESPONDING AUTHOR
Department of Orthopedics, University Medical Center Utrecht, Utrecht 3508GA, the Netherlands
Department of Biomechanical Engineering, Delft University of Technology, 2628 CD, Delft, the Netherlands
Azin Khodaei
Department of Orthopedics, University Medical Center Utrecht, Utrecht 3508GA, the Netherlands
Saber Amin Yavari
CORRESPONDING AUTHOR
Department of Orthopedics, University Medical Center Utrecht, Utrecht 3508GA, the Netherlands
Regenerative Medicine Centre Utrecht, Utrecht University, 3508 GA Utrecht, the Netherlands
Latest update: 26 Aug 2026
Short summary
This study delivers a practical rat model for both early and delayed implant‑site infections. We show which bacterial doses and states produce consistent infections at each time point, creating a dependable platform to evaluate new materials and treatments that prevent or clear implant infections.
This study delivers a practical rat model for both early and delayed implant‑site infections....
