Journal of Bone and Joint Infection
Journal of Bone and Joint Infection
JBJI
Articles | Volume 11, issue 4
Articles | Volume 11, issue 4
https://doi.org/10.5194/jbji-11-493-2026
© Author(s) 2026. This work is distributed under
the Creative Commons Attribution 4.0 License.
https://doi.org/10.5194/jbji-11-493-2026
© Author(s) 2026. This work is distributed under
the Creative Commons Attribution 4.0 License.
Articles | Volume 11, issue 4
Original full-length article
 | 
13 Aug 2026
Original full-length article |  | 13 Aug 2026

In vitro analysis of antiseptic solution effects on Staphylococcus aureus biofilms on orthopedic implant materials

Madison Balagtas, Kenneth Chrulski, Marina Feffer, Matthew Baldridge, and Ashley E. Levack

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Short summary

Bacterial infections on orthopedic implants are difficult to treat because bacteria form protective biofilms. We tested antiseptic solutions against Staphylococcus aureus biofilms on stainless steel. Povidone-iodine achieved the greatest reduction, exceeding 99.9% bacterial killing. Dilute povidone-iodine performed as well as full-strength, important since lower concentrations reduce tissue toxicity. Hypochlorous acid and chlorhexidine showed lower activity, while saline was minimally effective.

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