Articles | Volume 11, issue 4
https://doi.org/10.5194/jbji-11-441-2026
© Author(s) 2026. This work is distributed under the Creative Commons Attribution 4.0 License.
Review
| 
28 Jul 2026
Review |
| 28 Jul 2026
| 28 Jul 2026
Bromelain and N-acetylcysteine (BromAc) as novel adjunctive therapy for prosthetic joint infection: a narrative review
Cited articles
Abbaszadeh, A., Yilmaz, M. K., Izadi, N., Hoveidaei, A. H., Taheriazam, A., Abedi, A. A., and Parvizi, J.: Efficacy of Debridement, Antibiotics, and Implant Retention in Total Hip and Knee Arthroplasty: A Systematic Review and Meta-Analysis, J. Arthroplasty, 41, 19–38, https://doi.org/10.1016/j.arth.2025.05.121, 2026.
Aftab, M. H. S., Joseph, T., Almeida, R., Sikhauli, N., and Pietrzak, J. R. T.: Periprosthetic Joint Infection: A Multifaceted Burden Undermining Arthroplasty Success, Orthop. Rev., 17, 138205, https://doi.org/10.52965/001c.138205, 2025.
Al-Madboly, L. A., Aboulmagd, A., El-Salam, M. A., Kushkevych, I., and El-Morsi, R. M.: Microbial enzymes as powerful natural anti-biofilm candidates, Microb. Cell Factories, 23, 343, https://doi.org/10.1186/s12934-024-02610-y, 2024.
Blasi, F., Page, C., Rossolini, G. M., Pallecchi, L., Matera, M. G., Rogliani, P., and Cazzola, M.: The effect of N-acetylcysteine on biofilms: Implications for the treatment of respiratory tract infections, Respir. Med., 117, 190–197, https://doi.org/10.1016/j.rmed.2016.06.015, 2016.
Bourgonjen, Y. P., Hooning van Duyvenbode, J. F. F., van Dijk, B., Nurmohamed, F. R. H. A., Veltman, E. S., Vogely, H. C., and van der Wal, B. C. H.: Long-term outcome of two-stage revision surgery after hip and knee prosthetic joint infections: an observational study, J. Bone Joint Infect., 6, 379–387, https://doi.org/10.5194/jbji-6-379-2021, 2021.
