Articles | Volume 11, issue 3
https://doi.org/10.5194/jbji-11-363-2026
https://doi.org/10.5194/jbji-11-363-2026
Original full-length article
 | 
22 Jun 2026
Original full-length article |  | 22 Jun 2026

Neutrophil extracellular trap (NET)-related index as an indicator of periprosthetic joint infection

Tingrun Cui, Yongjian Liang, Zeyu Feng, Libo Hao, Guoqiang Zhang, Ming Ni, Jing Sheng, Dihua Shangguan, Jiying Chen, and Jun Fu

Cited articles

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Cai, Y., Liang, J., Chen, X., Zhang, G., Jing, Z., Zhang, R., Lv, L., Zhang, W., and Dang, X.: Synovial fluid neutrophil extracellular traps could improve the diagnosis of periprosthetic joint infection, Bone Joint Res., 12, 113–120, https://doi.org/10.1302/2046-3758.122.Bjr-2022-0391.R1, 2023. 
Cobra, H., Mozella, A. P., da Palma, I. M., Salim, R., and Leal, A. C.: Cell-free Deoxyribonucleic Acid: A Potential Biomarker of Chronic Periprosthetic Knee Joint Infection, J. Arthroplasty, 37, 2455–2459, https://doi.org/10.1016/j.arth.2022.07.002, 2022. 
Cutter, A. R. and Hayes, J. J.: A brief review of nucleosome structure, FEBS Lett., 589, 2914–2922, https://doi.org/10.1016/j.febslet.2015.05.016, 2015. 
de Sandes Kimura, O., Mozella, A., Cobra, H., Maciel Saraiva, A. C., Carvalho de Almendra Freitas, E. H., Cury Fernandes, M. B., Matheus Guimarães, J. A., Defino, H., and Leal, A. C.: Neutrophil Extracellular Trap-related Biomarkers Are Increased in the Synovial Fluid of Patients With Periprosthetic Joint Infections, Clin. Orthop. Relat. Res., 482, 727–733, https://doi.org/10.1097/corr.0000000000002891, 2024. 
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Short summary
Periprosthetic joint infection is the most challenging complication following arthroplasty. This study, utilizing clinically obtained synovial fluid specimens, confirmed the unique value of neutrophil extracellular traps and their constituent components in the diagnosis of periprosthetic joint infection, thereby enabling further precision in the diagnosis of periprosthetic joint infection and reducing the severe consequences associated with it.
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