Articles | Volume 11, issue 1
https://doi.org/10.5194/jbji-11-31-2026
https://doi.org/10.5194/jbji-11-31-2026
Original full-length article
 | 
13 Jan 2026
Original full-length article |  | 13 Jan 2026

The proportion of chronic periprosthetic joint infection patients with Candida isolates

Samuelson E. Osifo, Adrian Santana, Michael F. Shannon, Victoria R. Wong, Caroline F. Tyndall, Christian Cisneros, Niosha Parvizi, Brian A. Klatt, Johannes F. Plate, Nicolas S. Piuzzi, and Kenneth L. Urish

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Cited articles

Alkhawashki, H., Benevenia, J., Drago, L., and Kadkoy, Y.: A One- or Two-Stage Revision of Fungal Prosthetic Joint Infection: A Review of Current Knowledge, Pitfalls and Recommendations, Antibiotics, 14, https://doi.org/10.3390/antibiotics14070658, 2025. 
Aunon, A., Ortiz, I., Penarrubia, S., Alvaro, C., Torrecilla-Sadaba, E., Garcia-Canete, J., and Esteban, J.: Polymicrobial Prosthetic Joint Infections: Unraveling Risk Factors and Outcomes in a Single-Center Study, Microorganisms, 13, https://doi.org/10.3390/microorganisms13071679, 2025. 
Baecker, H., Frieler, S., Gessmann, J., Pauly, S., Schildhauer, T. A., and Hanusrichter, Y.: Three-stage revision arthroplasty for the treatment of fungal periprosthetic joint infection: outcome analysis of a novel treatment algorithm: a prospective study, Bone Jt. Open, 2, 671–678, https://doi.org/10.1302/2633-1462.28.BJO-2021-0002.R2, 2021. 
Brown, T. S., Petis, S. M., Osmon, D. R., Mabry, T. M., Berry, D. J., Hanssen, A. D., and Abdel, M. P.: Periprosthetic Joint Infection With Fungal Pathogens, J. Arthroplasty, 33, 2605–2612, https://doi.org/10.1016/j.arth.2018.03.003, 2018. 
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Short summary
Fungal organisms are conventionally estimated to account for 1 % –2 % of periprosthetic joint infection (PJI) cases, although diagnostic and reporting limitations may result in systematic underestimation. Using a quantitative missing-data sensitivity analysis across 23 studies encompassing 28 253 PJI cases, we estimated an adjusted Candida PJI proportion of approximately 5 %, increasing to nearly 10 % in chronic or refractory infections.
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