Articles | Volume 11, issue 1
https://doi.org/10.5194/jbji-11-21-2026
https://doi.org/10.5194/jbji-11-21-2026
Original full-length article
 | 
12 Jan 2026
Original full-length article |  | 12 Jan 2026

Fluoroquinolones vs. tetracycline agents combined with rifampicin for periprosthetic joint infections: a comparative study

Benoit Gachet, Olivier Robineau, Maxime Degrendel, Jules Bauer, Bertrand Cappeliez, Emmanuelle Bontemps, Ava Diarra, Pierre Patoz, Eric Beltrand, Eric Senneville, and Barthelemy Lafon-Desmurs

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Cited articles

Agwuh, K. N.: Pharmacokinetics and pharmacodynamics of the tetracyclines including glycylcyclines, Journal of Antimicrobial Chemotherapy, 58, 256–265, https://doi.org/10.1093/jac/dkl224, 2006. 
Anon: Recommandations de pratique clinique. Infections osteo-articulaires sur materiel (prothese, implant, osteosynthese), Médecine et Maladies Infectieuses, 39, 745–774, https://doi.org/10.1016/j.medmal.2009.05.003, 2009. 
Anon: Prothèse de hanche ou de genou: diagnostic et prise en charge de l'infection dans le mois suivant l'implantation, Haute Autorité de Santé, 134, https://www.has-sante.fr/jcms/c_1228574/fr/prothese-de-hanche-ou-de-genou-diagnostic-et-prise-en-charge-de-l-infection-dans-le-mois-suivant-l-implantation (last access: 19 December 2025), 2014. 
Asseray, N., Bourigault, C., Boutoille, D., Happi, L., Touchais, S., Corvec, S., Bemer, P., and Navas, D.: Levofloxacin at the usual dosage to treat bone and joint infections: a cohort analysis, Int. J. Antimicrob. Agents, 47, 478–481, https://doi.org/10.1016/j.ijantimicag.2016.03.003, 2016. 
Bart, G., Zeller, V., Kerroumi, Y., Heym, B., Meyssonnier, V., Desplaces, N., Kitzis, M. D., Ziza, J. M., and Marmor, S.: Minocycline Combined with Vancomycin for the Treatment of Methicillin-Resistant Coagulase-Negative Staphylococcal Prosthetic Joint Infection Managed with Exchange Arthroplasty, J. Bone Jt. Infect., 5, 110–117, https://doi.org/10.7150/jbji.43254, 2020. 
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Short summary
Infections represent a serious complication following the implantation of osteoarticular devices. Rifampicin in combination with fluoroquinolone is the most prescribed antibiotic regimen. Nevertheless, fluoroquinolones are associated with significant adverse effects. We sought to evaluate whether oral tetracyclines could serve as an alternative therapeutic option. Our findings suggest that tetracyclines may constitute a suitable alternative in cases where fluoroquinolones are not usable.
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