Articles | Volume 11, issue 1
https://doi.org/10.5194/jbji-11-21-2026
© Author(s) 2026. This work is distributed under
the Creative Commons Attribution 4.0 License.
the Creative Commons Attribution 4.0 License.
https://doi.org/10.5194/jbji-11-21-2026
© Author(s) 2026. This work is distributed under
the Creative Commons Attribution 4.0 License.
the Creative Commons Attribution 4.0 License.
Fluoroquinolones vs. tetracycline agents combined with rifampicin for periprosthetic joint infections: a comparative study
Benoit Gachet
Infectious Diseases Department, Gustave Dron Hospital, 155 rue du président CotyTourcoing, France
Department of Biostatistics, ULR 2694 METRICS Lille University, Lille, France
Olivier Robineau
Infectious Diseases Department, Gustave Dron Hospital, 155 rue du président CotyTourcoing, France
Department of Biostatistics, ULR 2694 METRICS Lille University, Lille, France
INSERM, Institut Pierre Louis d'Epidémiologie et de Santé Publique, UMR-S 1136, AP-HP, Paris, France
Maxime Degrendel
Infectious Diseases Department, Gustave Dron Hospital, 155 rue du président CotyTourcoing, France
Jules Bauer
Infectious Diseases Department, Gustave Dron Hospital, 155 rue du président CotyTourcoing, France
Bertrand Cappeliez
Infectious Diseases Department, Gustave Dron Hospital, 155 rue du président CotyTourcoing, France
Emmanuelle Bontemps
Infectious Diseases Department, Gustave Dron Hospital, 155 rue du président CotyTourcoing, France
Ava Diarra
Infectious Diseases Department, Gustave Dron Hospital, 155 rue du président CotyTourcoing, France
Pierre Patoz
Department of Microbiology, Gustave Dron Hospital, 155 rue du président Coty, Tourcoing, France
Eric Beltrand
Department of Orthopaedic Surgery Unit, Gustave Dron Hospital, 155 rue du président Coty, Tourcoing, France
Eric Senneville
Infectious Diseases Department, Gustave Dron Hospital, 155 rue du président CotyTourcoing, France
Department of Biostatistics, ULR 2694 METRICS Lille University, Lille, France
Barthelemy Lafon-Desmurs
CORRESPONDING AUTHOR
Infectious Diseases Department, Gustave Dron Hospital, 155 rue du président CotyTourcoing, France
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Efthymia Giannitsioti, Mauro José Salles, Andreas Mavrogenis, Dolors Rodriguez-Pardo, Ibai Los-Arcos, Alba Ribera, Javier Ariza, María Dolores del Toro, Sophie Nguyen, Eric Senneville, Eric Bonnet, Monica Chan, Maria Bruna Pasticci, Sabine Petersdorf, Natividad Benito, Nuala O' Connell, Antonio Blanco García, Gábor Skaliczki, Pierre Tattevin, Zeliha Kocak Tufan, Nikolaos Pantazis, Panayiotis D. Megaloikonomos, Panayiotis Papagelopoulos, Alejandro Soriano, Antonios Papadopoulos, and the ESGIAI collaborators study group
J. Bone Joint Infect., 7, 279–288, https://doi.org/10.5194/jbji-7-279-2022, https://doi.org/10.5194/jbji-7-279-2022, 2022
Short summary
Short summary
Our multicentre study on a lower-limb osteosynthesis-associated infection (OAI) cohort by multidrug (MDR) and extensively drug (XDR) resistant Gram-negative bacteria found the following: implant retention with debridement was mostly performed in early OAI; 50.9 % of patients achieved remission of infection; remission reached 50 % (MDR) vs. 25 % (XDR) in early OAI and 60 % (MDR) vs. 44.4 % (XDR) in late OAI; age (> 60) and multiple surgeries were independent factors influencing lack of remission.
Kevin Sermet, François Demaeght, Isabelle Alcaraz, Nathalie Viget, Julie Dauenhauer, Eric Senneville, and Olivier Robineau
J. Bone Joint Infect., 6, 207–209, https://doi.org/10.5194/jbji-6-207-2021, https://doi.org/10.5194/jbji-6-207-2021, 2021
Short summary
Short summary
Non-typeable Haemophilus influenzae (NTHi) is here described for the first time as responsible for an invasive infection involving blood, vertebral and joint infection in a 79-year-old woman. It was triggered by an asymptomatic sinus condition. Surgical drainage and antibiotic therapy allowed recovery. This case shows that a full cartography of NTHi infection is unavoidable and may reveal unknown dissemination mechanisms.
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Short summary
Infections represent a serious complication following the implantation of osteoarticular devices. Rifampicin in combination with fluoroquinolone is the most prescribed antibiotic regimen. Nevertheless, fluoroquinolones are associated with significant adverse effects. We sought to evaluate whether oral tetracyclines could serve as an alternative therapeutic option. Our findings suggest that tetracyclines may constitute a suitable alternative in cases where fluoroquinolones are not usable.
Infections represent a serious complication following the implantation of osteoarticular...