Journal of Bone and Joint Infection
Journal of Bone and Joint Infection
JBJI
Articles | Volume 11, issue 1
Articles | Volume 11, issue 1
https://doi.org/10.5194/jbji-11-21-2026
© Author(s) 2026. This work is distributed under
the Creative Commons Attribution 4.0 License.
https://doi.org/10.5194/jbji-11-21-2026
© Author(s) 2026. This work is distributed under
the Creative Commons Attribution 4.0 License.
Articles | Volume 11, issue 1
Original full-length article
 | 
12 Jan 2026
Original full-length article |  | 12 Jan 2026

Fluoroquinolones vs. tetracycline agents combined with rifampicin for periprosthetic joint infections: a comparative study

Benoit Gachet, Olivier Robineau, Maxime Degrendel, Jules Bauer, Bertrand Cappeliez, Emmanuelle Bontemps, Ava Diarra, Pierre Patoz, Eric Beltrand, Eric Senneville, and Barthelemy Lafon-Desmurs

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Short summary
Infections represent a serious complication following the implantation of osteoarticular devices. Rifampicin in combination with fluoroquinolone is the most prescribed antibiotic regimen. Nevertheless, fluoroquinolones are associated with significant adverse effects. We sought to evaluate whether oral tetracyclines could serve as an alternative therapeutic option. Our findings suggest that tetracyclines may constitute a suitable alternative in cases where fluoroquinolones are not usable.
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