Articles | Volume 10, issue 2
https://doi.org/10.5194/jbji-10-85-2025
https://doi.org/10.5194/jbji-10-85-2025
Review
 | 
28 Mar 2025
Review |  | 28 Mar 2025

The hidden connection between gut microbiota and periprosthetic joint infections: a scoping review

Alessandro Singlitico, Daniele Grassa, Rami Kaplan, Alessandro Smimmo, Giulio Maccauro, and Raffaele Vitiello

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Sex-related differences in periprosthetic joint infection research
Domenico De Mauro, Cesare Meschini, Giovanni Balato, Tiziana Ascione, Enrico Festa, Davide Bizzoca, Biagio Moretti, Giulio Maccauro, and Raffaele Vitiello
J. Bone Joint Infect., 9, 137–142, https://doi.org/10.5194/jbji-9-137-2024,https://doi.org/10.5194/jbji-9-137-2024, 2024
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Subject: Prosthesis-related infections | Topic: Epidemiology
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Cited articles

Al Bander, Z., Nitert, M. D., Mousa, A., and Naderpoor, N.: The Gut Microbiota and Inflammation: An Overview, Int. J. Environ. Res. Publ. Health, 17, 7618, https://doi.org/10.3390/ijerph17207618, 2020. 
Aleksandrova, K., Romero-Mosquera, B., and Hernandez, V.: Diet, Gut Microbiome and Epigenetics: Emerging Links with Inflammatory Bowel Diseases and Prospects for Management and Prevention, Nutrients, 9, 962, https://doi.org/10.3390/nu9090962, 2017. 
Arrieta, M. C., Bistritz, L., and Meddings, J. B.: Alterations in intestinal permeability, Gut, 55, 1512–1520, https://doi.org/10.1136/gut.2005.085373, 2006. 
Chisari, E., Cho, J., Wouthuyzen-Bakker, M., and Parvizi, J.: Periprosthetic Joint Infection and the Trojan Horse Theory: Examining the Role of Gut Dysbiosis and Epithelial Integrity, J. Arthroplast., 37, 1369–1374, https://doi.org/10.1016/j.arth.2022.03.030, 2022a. 
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Short summary
In this article we discuss how gut microbiota can affect the outcomes of a total joint arthroplasty. Total joint arthroplasty is a safe procedure for improving the quality of life in patients affected by arthrosis. Periprosthetic joint infection (PJI) is relatively rare but represents one of the most common causes of implant failure requiring revision surgery. Recently, there has been a major interest in the role of gut microbiome, in particular dysbiosis, as a risk factor for PJI.
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