Articles | Volume 10, issue 6
https://doi.org/10.5194/jbji-10-597-2025
https://doi.org/10.5194/jbji-10-597-2025
Original full-length article
 | 
10 Dec 2025
Original full-length article |  | 10 Dec 2025

A human-scale porcine fasciocutaneous and muscle flap model for the evaluation of ortho-plastic reconstructions of lower-limb defects

Josefine Slater, Maiken Stilling, Andreas Engel Krag, Sara Kousgaard Tøstesen, Mads Kristian Duborg Mikkelsen, Martin McNally, Alexander James Ramsden, Louise Kruse Jensen, Birgitte Jul Kiil, and Mats Bue

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Cited articles

Acland, R. D., Anderson, G., Siemionow, M., and McCabe, S.: Direct in vivo observations of embolic events in the microcirculation distal to a small-vessel anastomosis, Plast. Reconstr. Surg., 84, 280–288; 1989. 
Angelini, A., Tiengo, C., Cerchiaro, M. C., Soto, F., Biz, C., Messana, F., Bassetto, F., and Ruggieri, P.: Ortho-oncoplastic surgery in foot and ankle: A narrative overview on reconstruction of soft-tissue defects after oncologic resections, Microsurgery, 44, e31168, https://doi.org/10.1002/micr.31168, 2024. 
Bjarnsholt, T., Whiteley, M., Rumbaugh, K. P., Stewart, P. S., Jensen, P. O., and Frimodt-Moller, N.: The importance of understanding the infectious microenvironment, Lancet Infect Dis., 22, e88–e92, https://doi.org/10.1016/S1473-3099(21)00122-5, 2022. 
Calderon, W., Chang, N., and Mathes, S. J.: Comparison of the effect of bacterial inoculation in musculocutaneous and fasciocutaneous flaps, Plast Reconstr. Surg., 77, 785–794, https://doi.org/10.1097/00006534-198605000-00016, 1986. 
Cierny, G., 3rd, Mader, J. T., and Penninck, J. J.: A clinical staging system for adult osteomyelitis, Clin. Orthop. Relat. Res., 7–24, https://doi.org/10.1097/01.blo.0000088564.81746.62, 2003. 
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Short summary
We developed a pig model to study how different tissue flaps support the healing microenvironment of lower-leg composite defects. By measuring tissue metabolism and examining tissue samples under the microscope, we found distinct early responses between muscle and fascia-based flaps. This model may help researchers and clinicians better understand the healing of complex bone and soft-tissue defects and may provide a platform for evaluating clinically relevant ortho-plastic outcomes.
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