Articles | Volume 10, issue 6
https://doi.org/10.5194/jbji-10-597-2025
© Author(s) 2025. This work is distributed under
the Creative Commons Attribution 4.0 License.
the Creative Commons Attribution 4.0 License.
https://doi.org/10.5194/jbji-10-597-2025
© Author(s) 2025. This work is distributed under
the Creative Commons Attribution 4.0 License.
the Creative Commons Attribution 4.0 License.
Original full-length article
| 
10 Dec 2025
Original full-length article |
| 10 Dec 2025
| 10 Dec 2025
A human-scale porcine fasciocutaneous and muscle flap model for the evaluation of ortho-plastic reconstructions of lower-limb defects
Josefine Slater
CORRESPONDING AUTHOR
Aarhus Denmark Microdialysis Research (ADMIRE), Orthopaedic Research Laboratory, Aarhus University Hospital, Aarhus, 8200, Denmark
Department of Clinical Medicine, Aarhus University, Aarhus, 8200, Denmark
Maiken Stilling
Aarhus Denmark Microdialysis Research (ADMIRE), Orthopaedic Research Laboratory, Aarhus University Hospital, Aarhus, 8200, Denmark
Department of Clinical Medicine, Aarhus University, Aarhus, 8200, Denmark
Department of Orthopaedic Surgery, Aarhus University Hospital, Aarhus, 8200, Denmark
Andreas Engel Krag
Aarhus Denmark Microdialysis Research (ADMIRE), Orthopaedic Research Laboratory, Aarhus University Hospital, Aarhus, 8200, Denmark
Department of Clinical Medicine, Aarhus University, Aarhus, 8200, Denmark
Department of Plastic and Breast Surgery, Aarhus University Hospital, Aarhus, 8200, Denmark
Sara Kousgaard Tøstesen
Aarhus Denmark Microdialysis Research (ADMIRE), Orthopaedic Research Laboratory, Aarhus University Hospital, Aarhus, 8200, Denmark
Department of Clinical Medicine, Aarhus University, Aarhus, 8200, Denmark
Mads Kristian Duborg Mikkelsen
Aarhus Denmark Microdialysis Research (ADMIRE), Orthopaedic Research Laboratory, Aarhus University Hospital, Aarhus, 8200, Denmark
Department of Clinical Medicine, Aarhus University, Aarhus, 8200, Denmark
Martin McNally
Bone Infection Unit, Nuffield Orthopaedic Centre, Oxford University Hospital, Oxford, OX3 7LD, United Kingdom
Alexander James Ramsden
Bone Infection Unit, Nuffield Orthopaedic Centre, Oxford University Hospital, Oxford, OX3 7LD, United Kingdom
Louise Kruse Jensen
Department of Veterinary Animal Sciences, University of Copenhagen, Frederiksberg, Denmark
Birgitte Jul Kiil
Department of Plastic and Breast Surgery, Aarhus University Hospital, Aarhus, 8200, Denmark
Aarhus Denmark Microdialysis Research (ADMIRE), Orthopaedic Research Laboratory, Aarhus University Hospital, Aarhus, 8200, Denmark
Department of Clinical Medicine, Aarhus University, Aarhus, 8200, Denmark
Department of Orthopaedic Surgery, Aarhus University Hospital, Aarhus, 8200, Denmark
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Short summary
We developed a pig model to study how different tissue flaps support the healing microenvironment of lower-leg composite defects. By measuring tissue metabolism and examining tissue samples under the microscope, we found distinct early responses between muscle and fascia-based flaps. This model may help researchers and clinicians better understand the healing of complex bone and soft-tissue defects and may provide a platform for evaluating clinically relevant ortho-plastic outcomes.
We developed a pig model to study how different tissue flaps support the healing...
