Journal of Bone and Joint Infection
Journal of Bone and Joint Infection
JBJI
Articles | Volume 10, issue 6
Articles | Volume 10, issue 6
https://doi.org/10.5194/jbji-10-597-2025
© Author(s) 2025. This work is distributed under
the Creative Commons Attribution 4.0 License.
https://doi.org/10.5194/jbji-10-597-2025
© Author(s) 2025. This work is distributed under
the Creative Commons Attribution 4.0 License.
Articles | Volume 10, issue 6
Original full-length article
 | 
10 Dec 2025
Original full-length article |  | 10 Dec 2025

A human-scale porcine fasciocutaneous and muscle flap model for the evaluation of ortho-plastic reconstructions of lower-limb defects

Josefine Slater, Maiken Stilling, Andreas Engel Krag, Sara Kousgaard Tøstesen, Mads Kristian Duborg Mikkelsen, Martin McNally, Alexander James Ramsden, Louise Kruse Jensen, Birgitte Jul Kiil, and Mats Bue

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Short summary
We developed a pig model to study how different tissue flaps support the healing microenvironment of lower-leg composite defects. By measuring tissue metabolism and examining tissue samples under the microscope, we found distinct early responses between muscle and fascia-based flaps. This model may help researchers and clinicians better understand the healing of complex bone and soft-tissue defects and may provide a platform for evaluating clinically relevant ortho-plastic outcomes.
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