Articles | Volume 10, issue 6
https://doi.org/10.5194/jbji-10-459-2025
https://doi.org/10.5194/jbji-10-459-2025
Original full-length article
 | 
18 Nov 2025
Original full-length article |  | 18 Nov 2025

Microbiological profile of prosthetic joint infections in orthopedic oncology: a comparison with conventional joint arthroplasty

Joseph J. Connolly, Marcos R. Gonzalez, Joshua B. Davis, Youssef H. Moussaoui, Graham S. Goh, Antonia F. Chen, Adam S. Olsen, and Santiago A. Lozano-Calderón

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Ahmed Siddiqi, Zuhdi E. Abdo, Bryan D. Springer, and Antonia F. Chen
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Cited articles

Abdeen, A., Della Valle, C. J., Kendoff, D., and Chen, A. F.: The Paradox of Prosthetic Joint Infection and the Microbiome: Are Some Bacteria Actually Helpful?, Arthroplast. Today, 13, https://doi.org/10.1016/j.artd.2021.11.011, 2022. 
Boursi, B., Mamtani, R., Haynes, K., and Yang, Y.-X.: Recurrent antibiotic exposure may promote cancer formation – Another step in understanding the role of the human microbiota?, Eur. J. Cancer, 51, 2655–2664, https://doi.org/10.1016/j.ejca.2015.08.015, 2015. 
Carr, C., Wilcox, H., Burton, J. P., Menon, S., Al, K. F., O'Gorman, D., Lanting, B. A., Vasarhelyi, E. M., Neufeld, M., and Teeter, M. G.: Deciphering the low abundance microbiota of presumed aseptic hip and knee implants, PLoS One, 16, e0257471, https://doi.org/10.1371/journal.pone.0257471, 2021. 
Chisari, E., Cho, J., Wouthuyzen-Bakker, M., and Parvizi, J.: Gut permeability may be associated with periprosthetic joint infection after total hip and knee arthroplasty, Sci. Rep., 12, https://doi.org/10.1038/s41598-022-19034-6, 2022a. 
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Short summary
Periprosthetic joint infection  (PJI) is a serious complication of oncologic joint reconstructions with large endoprosthetics. Although the microbiology of PJI in conventional joint replacements is well characterized, it is lacking for oncologic patients. This study found that the microbiology of oncologic PJI is distinct from conventional joint replacement PJI and that microbiology varies in different cancer subpopulations. These findings will help improve targeted antibiotic treatment for PJI.
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