Journal of Bone and Joint Infection
Journal of Bone and Joint Infection
JBJI
Articles | Volume 10, issue 5
Articles | Volume 10, issue 5
https://doi.org/10.5194/jbji-10-363-2025
© Author(s) 2025. This work is distributed under
the Creative Commons Attribution 4.0 License.
https://doi.org/10.5194/jbji-10-363-2025
© Author(s) 2025. This work is distributed under
the Creative Commons Attribution 4.0 License.
Articles | Volume 10, issue 5
Review
 | 
10 Oct 2025
Review |  | 10 Oct 2025

Serum inflammatory markers for the screening and diagnosis of periprosthetic joint infection: a systematic review and meta-analysis

Irene K. Sigmund, Matthew J. Dietz, Marta Sabater-Martos, Antony J. R. Palmer, Nicolas Cortés-Penfield, and the “Serum Marker Workgroup” for the Unified PJI Definition Taskforce

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Latest update: 08 Sep 2026
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Short summary
Serum C-reactive protein, fibrinogen, and interleukin-6 show the best performance among serum markers for diagnosing periprosthetic joint infection (PJI), but they lack sufficient accuracy to confirm or exclude infection reliably. These markers should be re-evaluated in future PJI definitions, as they are not suitable as stand-alone tests. Given their limitations and the superior diagnostic performance of synovial markers, the role of serum markers in PJI diagnosis should be reconsidered.
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