Articles | Volume 9, issue 1
https://doi.org/10.5194/jbji-9-99-2024
© Author(s) 2024. This work is distributed under
the Creative Commons Attribution 4.0 License.
the Creative Commons Attribution 4.0 License.
https://doi.org/10.5194/jbji-9-99-2024
© Author(s) 2024. This work is distributed under
the Creative Commons Attribution 4.0 License.
the Creative Commons Attribution 4.0 License.
Characteristics and management of periprosthetic joint infections caused by rapidly growing mycobacteria: a retrospective study and a review of the literature
Pansachee Damronglerd
CORRESPONDING AUTHOR
Division of Public Health, Infectious Diseases and Occupational Medicine, Mayo Clinic, 200 First Street SW, Rochester, Minnesota, USA
Division of Infectious Diseases, Faculty of Medicine, Thammasat University, Pathum Thani, Thailand
Eibhlin Higgins
Division of Public Health, Infectious Diseases and Occupational Medicine, Mayo Clinic, 200 First Street SW, Rochester, Minnesota, USA
Madiha Fida
Division of Public Health, Infectious Diseases and Occupational Medicine, Mayo Clinic, 200 First Street SW, Rochester, Minnesota, USA
Don Bambino Geno Tai
Division of Infectious Diseases and International Medicine, University of Minnesota, Minneapolis, Minnesota, USA
Aaron J. Tande
Division of Public Health, Infectious Diseases and Occupational Medicine, Mayo Clinic, 200 First Street SW, Rochester, Minnesota, USA
Matthew P. Abdel
Department of Orthopedic Surgery, Mayo Clinic, Rochester, Minnesota, USA
Omar M. Abu Saleh
Division of Public Health, Infectious Diseases and Occupational Medicine, Mayo Clinic, 200 First Street SW, Rochester, Minnesota, USA
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Francesco Petri, Omar Mahmoud, Said El Zein, Ahmad Nassr, Brett A. Freedman, Jared T. Verdoorn, Aaron J. Tande, and Elie F. Berbari
J. Bone Joint Infect., 9, 173–182, https://doi.org/10.5194/jbji-9-173-2024, https://doi.org/10.5194/jbji-9-173-2024, 2024
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In recent years, there has been an increase in scientific production on native vertebral osteomyelitis (NVO), a condition whose incidence is rising and that can be highly detrimental to health. However, there is no consensus on the definition of this syndrome in the medical community. Therefore, we propose a new framework to synthesize the diagnostic tools at our disposal. This can help to advance research further and guide patient care more effectively.
Nicolás Cortés-Penfield, Don Bambino Geno Tai, and Angela Hewlett
J. Bone Joint Infect., 9, 161–165, https://doi.org/10.5194/jbji-9-161-2024, https://doi.org/10.5194/jbji-9-161-2024, 2024
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This survey study describes the composition of US-based orthopedic infectious diseases (Ortho ID) teams across more than a dozen large academic medical centers, finding many institutions have dedicated Ortho ID clinics or inpatient services. These teams are highly valued by both ID clinicians and surgeons for engendering strong multidisciplinary relationships and improving patient outcomes.
Said El Zein, Elie F. Berbari, Allison M. LeMahieu, Anil Jagtiani, Parham Sendi, Abinash Virk, Mark E. Morrey, and Aaron J. Tande
J. Bone Joint Infect., 9, 107–115, https://doi.org/10.5194/jbji-9-107-2024, https://doi.org/10.5194/jbji-9-107-2024, 2024
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Our study investigated olecranon septic bursitis treatment, focusing on postsurgical antibiotic use. Analyzing 22 years of Mayo Clinic data, we found that smoking and not administering antibiotics following surgery led to poorer outcomes. A 3-week antibiotic course following surgery was most effective. Our findings suggest that a subset of patients may benefit from longer courses of antibiotics; however, further research is needed to confirm these findings.
Matteo Passerini, Julian Maamari, Don Bambino Geno Tai, Robin Patel, Aaron J. Tande, Zelalem Temesgen, and Elie F. Berbari
J. Bone Joint Infect., 8, 143–149, https://doi.org/10.5194/jbji-8-143-2023, https://doi.org/10.5194/jbji-8-143-2023, 2023
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Physicians have difficulties interpreting the isolation of Cutibacterium acnes in the spine tissue. Here we provide the experience of our center about this topic, adding data that can help physicians in their choices. Our results show that some clinical, radiological, and microbiological features can help distinguish patients to treat or not to treat. Moreover, treatment with parenteral beta-lactams appears to be effective, but targeted oral therapy could be a valid alternative.
Eibhlin Higgins, Don Bambino Geno Tai, Brian Lahr, Gina A. Suh, Elie F. Berbari, Kevin I. Perry, Matthew P. Abdel, and Aaron J. Tande
J. Bone Joint Infect., 8, 125–131, https://doi.org/10.5194/jbji-8-125-2023, https://doi.org/10.5194/jbji-8-125-2023, 2023
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This retrospective case-matched study evaluated males and females with staphylococcal PJI (periprosthetic joint infection) treated with two-stage exchange arthroplasty. We matched 156 males and females for age, type of staphylococcal infection, and joint involved. We compared clinical parameters related to presentation, treatment, and outcome. We did not find a statistically significant difference in outcome between males and females treated with the same surgical approach at our institution.
Kareme D. Alder, Anthony P. Fiegen, Matthew M. Rode, Don Bambino Geno Tai, Gina A. Suh, Abinash Virk, and Nicholas Pulos
J. Bone Joint Infect., 8, 39–44, https://doi.org/10.5194/jbji-8-39-2023, https://doi.org/10.5194/jbji-8-39-2023, 2023
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We present the first published case of bilateral extensor tenosynovitis caused by Coxiella burnetii. C. burnetii should be considered in patients with inflammatory osteoarticular disease, including tenosynovitis, when conventional cultures are negative especially in elderly, male, or immunocompromised patients with exposure to animals.
Matteo Passerini, Julian Maamari, Tarek Nayfeh, Leslie C. Hassett, Aaron J. Tande, Mohammad H. Murad, Zelalem Temesgen, and Elie F. Berbari
J. Bone Joint Infect., 7, 249–257, https://doi.org/10.5194/jbji-7-249-2022, https://doi.org/10.5194/jbji-7-249-2022, 2022
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Despite a growing interest in oral therapy for native vertebral osteomyelitis, there is no evidence to recommend oral or parenteral therapy. From our single-center experience combined with a systematic review and a meta-analysis of the available literature, there is insufficient evidence to conclude that there is a difference in proportion of failure and relapse between an early switch to oral antibiotics and prolonged parenteral therapy. Further studies are needed to increase the evidence.
Talha Riaz, Matthew Howard, Felix Diehn, Aaron Joseph Tande, Courtney Ross, Paul Huddleston, and Elie Berbari
J. Bone Joint Infect., 7, 213–219, https://doi.org/10.5194/jbji-7-213-2022, https://doi.org/10.5194/jbji-7-213-2022, 2022
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In this study, we prospectively enrolled patients with a suspected diagnosis of native vertebral osteomyelitis (NVO) undergoing image-guided needle aspiration of the intervertebral disc. Based on this pilot study, a high manual cell count or a high neutrophilic predominance from the disc aspirate was associated with the diagnosis of NVO.
Katharine Dobos, Gina A. Suh, Aaron J. Tande, and Shanthi Kappagoda
J. Bone Joint Infect., 7, 137–141, https://doi.org/10.5194/jbji-7-137-2022, https://doi.org/10.5194/jbji-7-137-2022, 2022
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This paper describes five cases of prosthetic joint infection (PJI) caused by Mycobacterium avium complex (MAC). Infections occurred in both immune competent and immunosuppressed patients. Interestingly, using the Musculoskeletal Infection Society diagnostic criteria for PJI may miss some cases of MAC PJI. Treatment courses and outcomes are described.
Julian Maamari, Aaron J. Tande, Felix Diehn, Don Bambino Geno Tai, and Elie F. Berbari
J. Bone Joint Infect., 7, 23–32, https://doi.org/10.5194/jbji-7-23-2022, https://doi.org/10.5194/jbji-7-23-2022, 2022
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The yearly incidence of native vertebral osteomyelitis (NVO) is increasing. In 2013 the prevalence of NVO in the USA was 5.4 cases per 100 000. Delays in the diagnosis of NVO remain common, in part due to the insidious nature of the infection and its related symptoms. The mean time between the onset of symptoms to diagnosis of NVO is 45.5 d. We herein review available and novel diagnostic modalities at the disposal of healthcare providers to reach an accurate and timely diagnosis of NVO.
Don Bambino Geno Tai, Nathan J. Brinkman, Omar Abu Saleh, Douglas R. Osmon, Matthew P. Abdel, and Christina G. Rivera
J. Bone Joint Infect., 6, 147–150, https://doi.org/10.5194/jbji-6-147-2021, https://doi.org/10.5194/jbji-6-147-2021, 2021
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Antibiotics are frequently used in bone cement during joint replacements or treatment of bone and joint infections. Amikacin is rarely used in bone cement, particularly the liquid formulation. We describe a series of patients in which liquid amikacin was incorporated into bone cement. We did not observe the occurrence of adverse drug reactions definitively attributed to its use. All patients had favorable outcomes.
Stephanie L. Grach and Aaron J. Tande
J. Bone Joint Infect., 6, 39–42, https://doi.org/10.5194/jbji-6-39-2020, https://doi.org/10.5194/jbji-6-39-2020, 2020
Related subject area
Subject: Prosthesis-related infections | Topic: Epidemiology
Predicting periprosthetic joint infection: external validation of preoperative prediction models
Sex-related differences in periprosthetic joint infection research
Sex-specific analysis of clinical features and outcomes in staphylococcal periprosthetic joint infections managed with two-stage exchange arthroplasty
Characteristics and outcomes of culture-negative prosthetic joint infections from the Prosthetic Joint Infection in Australia and New Zealand Observational (PIANO) cohort study
Has the time come for regional periprosthetic joint infection centers in the United States? A first-year experience
Seung-Jae Yoon, Paul C. Jutte, Alex Soriano, Ricardo Sousa, Wierd P. Zijlstra, and Marjan Wouthuyzen-Bakker
J. Bone Joint Infect., 9, 231–239, https://doi.org/10.5194/jbji-9-231-2024, https://doi.org/10.5194/jbji-9-231-2024, 2024
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This study validated three models for predicting infection after hip and knee replacement surgery. By analyzing data from 2684 patients in the Netherlands, Portugal, and Spain, we found that the models developed by Tan, Del Toro, and Bülow effectively identified high-risk patients. These models can be used to enhance preoperative counseling and to tailor infection prevention measures individually, potentially improving outcomes and reducing healthcare costs.
Domenico De Mauro, Cesare Meschini, Giovanni Balato, Tiziana Ascione, Enrico Festa, Davide Bizzoca, Biagio Moretti, Giulio Maccauro, and Raffaele Vitiello
J. Bone Joint Infect., 9, 137–142, https://doi.org/10.5194/jbji-9-137-2024, https://doi.org/10.5194/jbji-9-137-2024, 2024
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This study investigates sex-related differences in periprosthetic Joint Infections (PJIs) after total joint arthroplasty. A systematic review of nine studies reveals a higher risk of infectious complications in males compared to females, as indicated by statistically significant findings in half of the studies. This underscores the need for ongoing sex-related analysis to enhance evidence and insights in the field of PJIs.
Eibhlin Higgins, Don Bambino Geno Tai, Brian Lahr, Gina A. Suh, Elie F. Berbari, Kevin I. Perry, Matthew P. Abdel, and Aaron J. Tande
J. Bone Joint Infect., 8, 125–131, https://doi.org/10.5194/jbji-8-125-2023, https://doi.org/10.5194/jbji-8-125-2023, 2023
Short summary
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This retrospective case-matched study evaluated males and females with staphylococcal PJI (periprosthetic joint infection) treated with two-stage exchange arthroplasty. We matched 156 males and females for age, type of staphylococcal infection, and joint involved. We compared clinical parameters related to presentation, treatment, and outcome. We did not find a statistically significant difference in outcome between males and females treated with the same surgical approach at our institution.
Sarah Browning, Laurens Manning, Sarah Metcalf, David L. Paterson, James O. Robinson, Benjamin Clark, and Joshua S. Davis
J. Bone Joint Infect., 7, 203–211, https://doi.org/10.5194/jbji-7-203-2022, https://doi.org/10.5194/jbji-7-203-2022, 2022
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Culture-negative (CN) prosthetic joint infections (PJIs) present significant challenges for clinicians. While previous retrospective analyses have been conducted, inconsistencies in inclusion criteria and treatment success measures limit the opportunity for direct comparisons and use in guiding clinical practice. We compared baseline characteristics and outcomes of CN with culture-positive (CP) cases in a large multicentre prospective cohort and demonstrated improved overall outcomes in CN PJI.
Murillo Adrados, Michael M. Valenzuela, Bryan D. Springer, Susan M. Odum, Thomas K. Fehring, and Jesse E. Otero
J. Bone Joint Infect., 7, 51–53, https://doi.org/10.5194/jbji-7-51-2022, https://doi.org/10.5194/jbji-7-51-2022, 2022
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Areas in orthopedics, such as spinal metastasis and sarcomas, have shown benefits of concentrated care in specialized centers. Currently in the US, no such centers exist for treatment of periprosthetic joint infection (PJI). We established a PJI center and review our first-year experience. Additionally, we note the complexity and volume of referrals, in addition to the abundant opportunities for research that referral centers provide. PJI centers are feasible and can improve PJI care.
Cited articles
Ando, J., Miyata, R., Harada, M., Takeuchi, M., Kasahara, K., Yoshimoto, Y., Koyama, F., and Kuwahara, M.: A Ventral Hernia-repair-related Mycobacterium mageritense Mesh Infection Treated with NPWT without Mesh Removal, Plast. Reconstr. Surg. Glob. Open, 9, e3799, https://doi.org/10.1097/GOX.0000000000003799, 2021.
Badelon, O., David, H., Meyer, L., Radault, A., and Zucman, J.: [Mycobacterium fortuitum infection after total hip prosthesis. A report of 3 cases (author's transl.)], Rev. Chir. Orthop. Reparatrice. Appar. Mot., 65, 39–43, 1979.
Brown-Elliott, B. A. and Wallace Jr., R. J.: Clinical and taxonomic status of pathogenic nonpigmented or late-pigmenting rapidly growing mycobacteria, Clin. Microbiol. Rev., 15, 716–746, https://doi.org/10.1128/CMR.15.4.716-746.2002, 2002.
Caravedo Martinez, M. A. and Blanton, L. S.: Mycobacterium mageritense Prosthetic Joint Infection, Case Rep. Infect. Dis., 2020, 8845430, https://doi.org/10.1155/2020/8845430, 2020.
Cariello, P. F., Kwak, E. J., Abdel-Massih, R. C., and Silveira, F. P.: Safety and tolerability of clofazimine as salvage therapy for atypical mycobacterial infection in solid organ transplant recipients, Transpl. Infect. Dis., 17, 111–118, https://doi.org/10.1111/tid.12340, 2015.
Cassidy, P. M., Hedberg, K., Saulson, A., McNelly, E., and Winthrop, K. L.: Nontuberculous mycobacterial disease prevalence and risk factors: a changing epidemiology, Clin. Infect. Dis., 49, e124–129, https://doi.org/10.1086/648443, 2009.
Domenech, P., Jimenez, M. S., Menendez, M. C., Bull, T. J., Samper, S., Manrique, A., and Garcia, M. J.: Mycobacterium mageritense sp. nov, Int. J. Syst. Bacteriol., 47, 535–540, https://doi.org/10.1099/00207713-47-2-535, 1997.
Eid, A. J., Berbari, E. F., Sia, I. G., Wengenack, N. L., Osmon, D. R., and Razonable, R. R.: Prosthetic joint infection due to rapidly growing mycobacteria: report of 8 cases and review of the literature, Clin. Infect. Dis., 45, 687–694, https://doi.org/10.1086/520982, 2007.
Garcia-Zamora, E., Sanz-Robles, H., Elosua-Gonzalez, M., Rodriguez-Vasquez, X., and Lopez-Estebaranz, J. L.: Cutaneous infection due to Mycobacterium immunogenum: an European case report and review of the literature, Dermatol. Online J., 23, https://doi.org/10.5070/D32310036992, 2017.
Goldstein, N., St Clair, J. B., Kasperbauer, S. H., Daley, C. L., and Lindeque, B.: Nontuberculous Mycobacterial Musculoskeletal Infection Cases from a Tertiary Referral Center, Colorado, USA, Emerg. Infect. Dis., 25, 1075–1083, https://doi.org/10.3201/eid2406.181041, 2019.
Gordon, T., Nadziejko, C., Galdanes, K., Lewis, D., and Donnelly, K.: Mycobacterium immunogenum causes hypersensitivity pneumonitis-like pathology in mice, Inhal. Toxicol., 18, 449–456, https://doi.org/10.1080/08958370600563904, 2006.
Henry, M. W., Miller, A. O., Kahn, B., Windsor, R. E., and Brause, B. D.: Prosthetic joint infections secondary to rapidly growing mycobacteria: Two case reports and a review of the literature, Infect. Dis. (Lond.), 48, 453–460, https://doi.org/10.3109/23744235.2016.1142673, 2016.
Jitmuang, A., Yuenyongviwat, V., Charoencholvanich, K., and Chayakulkeeree, M.: Rapidly-growing mycobacterial infection: a recognized cause of early-onset prosthetic joint infection, BMC Infect. Dis., 17, 802, https://doi.org/10.1186/s12879-017-2926-3, 2017.
Kim, M., Ha, C. W., Jang, J. W., and Park, Y. B.: Rapidly growing non-tuberculous mycobacteria infection of prosthetic knee joints: A report of two cases, Knee, 24, 869–875, https://doi.org/10.1016/j.knee.2017.04.015, 2017.
Koyama, T., Funakoshi, Y., Imamura, Y., Nishimura, S., Fujishima, Y., Toyoda, M., Kiyota, N., Tanino, H., and Minami, H.: Device-related Mycobacterium mageritense Infection in a Patient Treated with Nivolumab for Metastatic Breast Cancer, Intern. Med., 60, 3485–3488, https://doi.org/10.2169/internalmedicine.6550-20, 2021.
Kurtz, S. M., Lau, E., Watson, H., Schmier, J. K., and Parvizi, J.: Economic burden of periprosthetic joint infection in the United States, J. Arthroplasty, 27, 61–65, https://doi.org/10.1016/j.arth.2012.02.022, 2012.
Kurz, S. G., Zha, B. S., Herman, D. D., Holt, M. R., Daley, C. L., Ruminjo, J. K., and Thomson, C. C.: Summary for Clinicians: 2020 Clinical Practice Guideline Summary for the Treatment of Nontuberculous Mycobacterial Pulmonary Disease, Ann. Am. Thorac. Soc., 17, 1033–1039, https://doi.org/10.1513/AnnalsATS.202003-222CME, 2020.
Loots, M. A., de Jong, M. D., van Soolingen, D., Wetsteyn, J. C., and Faber, W. R.: Chronic leg ulcer caused by Mycobacterium immunogenum, J. Travel. Med., 12, 347–349, https://doi.org/10.2310/7060.2005.12609, 2005.
McMullen, A. R., Mattar, C., Kirmani, N., and Burnham, C. A.: Brown-Pigmented Mycobacterium mageritense as a Cause of Prosthetic Valve Endocarditis and Bloodstream Infection, J. Clin. Microbiol., 53, 2777–2780, https://doi.org/10.1128/JCM.01041-15, 2015.
McNeil, E. P., Goldfarb, N., Hannon, G. R., Miller, D. D., and Farah, R. S.: Mycobacterium immunogenum folliculitis on the lower extremities of a healthy young adult, Clin. Exp. Dermatol., 44, 328–330, https://doi.org/10.1111/ced.13703, 2019.
Parvizi, J., Tan, T. L., Goswami, K., Higuera, C., Della Valle, C., Chen, A. F., and Shohat, N.: The 2018 Definition of Periprosthetic Hip and Knee Infection: An Evidence-Based and Validated Criteria, J. Arthroplasty, 33, 1309–1314, https://doi.org/10.1016/j.arth.2018.02.078, 2018.
Prevots, D. R., Shaw, P. A., Strickland, D., Jackson, L. A., Raebel, M. A., Blosky, M. A., Montes de Oca, R., Shea, Y. R., Seitz, A. E., Holland, S. M., and Olivier, K. N.: Nontuberculous mycobacterial lung disease prevalence at four integrated health care delivery systems, Am. J. Respir. Crit. Care Med., 182, 970–976, https://doi.org/10.1164/rccm.201002-0310OC, 2010.
Spaulding, A. B., Lai, Y. L., Zelazny, A. M., Olivier, K. N., Kadri, S. S., Prevots, D. R., and Adjemian, J.: Geographic Distribution of Nontuberculous Mycobacterial Species Identified among Clinical Isolates in the United States, 2009–2013, Ann. Am. Thorac. Soc., 14, 1655–1661, https://doi.org/10.1513/AnnalsATS.201611-860OC, 2017.
Tai, D. B. G., Patel, R., Abdel, M. P., Berbari, E. F., and Tande, A. J.: Microbiology of hip and knee periprosthetic joint infections: a database study, Clin. Microbiol. Infect., 28, 255–259, https://doi.org/10.1016/j.cmi.2021.06.006, 2022.
van Ingen, J., Totten, S. E., Helstrom, N. K., Heifets, L. B., Boeree, M. J., and Daley, C. L.: In vitro synergy between clofazimine and amikacin in treatment of nontuberculous mycobacterial disease, Antimicrob. Agents Chemother., 56, 6324–6327, https://doi.org/10.1128/AAC.01505-12, 2012.
Wilson, R. W., Steingrube, V. A., Bottger, E. C., Springer, B., Brown-Elliott, B. A., Vincent, V., Jost, K. C., Zhang, Y., Garcia, M. J., Chiu, S. H., Onyi, G. O., Rossmoore, H., Nash, D. R., and Wallace, R. J.: Mycobacterium immunogenum sp. nov., a novel species related to Mycobacterium abscessus and associated with clinical disease, pseudo-outbreaks and contaminated metalworking fluids: an international cooperative study on mycobacterial taxonomy, Int. J. Syst. Evol. Microbiol., 51, 1751–1764, https://doi.org/10.1099/00207713-51-5-1751, 2001.
Short summary
This work investigates periprosthetic joint infection (PJI) caused by rapidly growing mycobacteria (RGM) following total joint arthroplasty. Eight patients were identified as part of a retrospective review. The isolated RGM species included Mycobacterium abscessus (three cases), M. fortuitum (three cases), and one case each of M. immunogenum and M. mageritense. We provide novel insights into the successful treatment of PJIs caused by newly identified RGM (M. immunogenum and M. mageritense).
This work investigates periprosthetic joint infection (PJI) caused by rapidly growing...