Articles | Volume 9, issue 1
https://doi.org/10.5194/jbji-9-9-2024
© Author(s) 2024. This work is distributed under
the Creative Commons Attribution 4.0 License.
the Creative Commons Attribution 4.0 License.
https://doi.org/10.5194/jbji-9-9-2024
© Author(s) 2024. This work is distributed under
the Creative Commons Attribution 4.0 License.
the Creative Commons Attribution 4.0 License.
Multiplex PCR test as an intra-operative diagnostic tool for periprosthetic joint infection in presumed aseptic revision hip and knee arthroplasty: a 1-year follow-up study of 200 cases
Thomas J. A. van Schaik
CORRESPONDING AUTHOR
Department of Orthopaedic Surgery, Sint Maartenskliniek, Nijmegen, the Netherlands
Department of Orthopaedic Surgery, Rijnstate Ziekenhuis, Arnhem, the Netherlands
Department of Orthopaedic Surgery, Radboud University Medical Center, Nijmegen, the Netherlands
Petra J. C. Heesterbeek
Department of Research, Sint Maartenskliniek, Nijmegen, the Netherlands
Job L. C. van Susante
Department of Orthopaedic Surgery, Rijnstate Ziekenhuis, Arnhem, the Netherlands
Wim H. C. Rijnen
Department of Orthopaedic Surgery, Radboud University Medical Center, Nijmegen, the Netherlands
Jon H. M. Goosen
Department of Orthopaedic Surgery, Sint Maartenskliniek, Nijmegen, the Netherlands
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Yoni Lodewijk-van den Brink, Jon H. M. Goosen, Denise S. C. Telgt, Marrigje Nabuurs-Franssen, and Karin C. M. Veerman
J. Bone Joint Infect., 11, 229–235, https://doi.org/10.5194/jbji-11-229-2026, https://doi.org/10.5194/jbji-11-229-2026, 2026
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Early postoperative orthopaedic infections require rapid empirical antibiotic treatment, but the optimal regimen may differ by anatomical site. In this retrospective cohort study, empirical coverage was evaluated across anatomical sites. Vancomycin combined with ceftriaxone provided high coverage for most sites, while foot and ankle infections showed higher rates of resistant Gram-negative bacteria. These findings support an anatomy-specific approach to treatment.
Ruben Scholten, Gerjon Hannink, Matthijs P. Somford, and Job L. C. van Susante
J. Bone Joint Infect., 10, 207–215, https://doi.org/10.5194/jbji-10-207-2025, https://doi.org/10.5194/jbji-10-207-2025, 2025
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This study explores the effectiveness of repeated debridement, antibiotics, and implant retention (DAIR) for early periprosthetic joint infections (PJIs) after total joint arthroplasty. It shows that repeated DAIR procedures may achieve over 75 % success, which indicates that this approach may have value in managing early PJIs after weighing the benefits and risks of repeated DAIR against implant removal for each patient.
Michelle M. J. Jacobs, Petra J. C. Heesterbeek, Karin Veerman, and Jon H. M. Goosen
J. Bone Joint Infect., 10, 185–192, https://doi.org/10.5194/jbji-10-185-2025, https://doi.org/10.5194/jbji-10-185-2025, 2025
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We compared the outcomes of one-stage and two-stage revision surgeries for periprosthetic joint infections of the knee and hip joints. Patients in both groups had similar reinfection rates and functional recovery, but two-stage hip patients experienced more complications, partly due to the temporary use of cement spacers. Our findings suggest that one-stage revision may be a viable alternative to two-stage revision, potentially reducing complications without increasing reinfection risk.
Thomas J. A. van Schaik, Lex D. de Jong, Maurits P. A. van Meer, Jon H. M. Goosen, and Matthijs P. Somford
J. Bone Joint Infect., 7, 259–267, https://doi.org/10.5194/jbji-7-259-2022, https://doi.org/10.5194/jbji-7-259-2022, 2022
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This systematic review presents the results regarding the concordance rate between preoperative synovial fluid and intraoperative tissue culturing in patients with a prosthetic joint infection (PJI). The included studies had heterogeneous results and were at a high risk of bias. Higher-quality future research may help to better understand the true concordance between these cultures. This may result in better guidance for orthopedic surgeons regarding the treatment of patients with PJI.
Joyce van Eck, Wai-Yan Liu, Jon H. M. Goosen, Wim H. C. Rijnen, Babette C. van der Zwaard, Petra Heesterbeek, Walter van der Weegen, and the further members of Regional Prosthetic Joint
Infection Group
J. Bone Joint Infect., 7, 143–149, https://doi.org/10.5194/jbji-7-143-2022, https://doi.org/10.5194/jbji-7-143-2022, 2022
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Patients who receive joint replacement surgery might suffer from infection, which usually requires another surgery to clean the prosthesis and remove infected tissue. This tissue is analysed for bacteria in order to start appropriate antibiotic therapy. Bacteria are not always found, calling the appropriateness of the second surgery into question. We compared the treatment outcome in a large group of culture-positive and culture-negative patients and noticed a better outcome in the latter group.
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Short summary
This study evaluated the use of an automated custom-made multiplex PCR (mPCR) test of synovial fluid in presumed aseptic revision hip and knee arthroplasties. Of all 200 patients, none developed a periprosthetic joint infection (PJI) within the first year after surgery. The study showed that a positive mPCR test did not have value for prediction of PJI development. Therefore, the authors do not recommend using this test in presumed aseptic hip or knee revision surgery.
This study evaluated the use of an automated custom-made multiplex PCR (mPCR) test of synovial...