Articles | Volume 9, issue 1
https://doi.org/10.5194/jbji-9-87-2024
© Author(s) 2024. This work is distributed under
the Creative Commons Attribution 4.0 License.
the Creative Commons Attribution 4.0 License.
https://doi.org/10.5194/jbji-9-87-2024
© Author(s) 2024. This work is distributed under
the Creative Commons Attribution 4.0 License.
the Creative Commons Attribution 4.0 License.
Original full-length article
| 
28 Feb 2024
Original full-length article |
| 28 Feb 2024
| 28 Feb 2024
Potential value of a rapid syndromic multiplex PCR for the diagnosis of native and prosthetic joint infections: a real-world evidence study
Stéphanie Pascual
CORRESPONDING AUTHOR
bioMérieux, Marcy l'Etoile, France
Brooklyn Noble
bioMérieux, Salt Lake City, USA
Nusreen Ahmad-Saeed
University Hospital Southampton NHS Foundation Trust, Southampton, United Kingdom
Catherine Aldridge
Newcastle Upon Tyne Hospitals NHS Foundation Trust, Newcastle Upon Tyne, United Kingdom
Simone Ambretti
S. Orsola Bologna, Microbiology Unit, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy
Sharon Amit
Sheba Medical Center, Ramat Gan, Israel
Rachel Annett
University Hospital of Wales, Cardiff, Wales, United Kingdom
Shaan Ashk O'Shea
University Hospital Southampton NHS Foundation Trust, Southampton, United Kingdom
Anna Maria Barbui
San Giovanni Battista, Department of Public Health and Pediatrics Microbiology and Virology Unit, Città della Salute e della Scienza, Turin, Italy
Gavin Barlow
Hull University Teaching Hospitals NHS Trust, Hull, United Kingdom
Lucinda Barrett
Oxford University Hospitals (OUH), Oxford, United Kingdom
Mario Berth
AZ Alma, Eeklo, Belgium
Alessandro Bondi
Department of Public Health and Pediatrics, University of Turin, Turin, Italy
Nicola Boran
Mater Misericordiae University Hospital, Dublin, Ireland
Sara E. Boyd
Chelsea and Westminster NHS Foundation Trust, London, United Kingdom
Catarina Chaves
Centro Hospitalar e Universitário de Coimbra, Coimbra, Portugal
Martin Clauss
University Hospital Basel, Basel, Switzerland
Peter Davies
NHS Greater Glasgow and Clyde, Glasgow Royal Infirmary, University of Glasgow, Glasgow, United Kingdom
Ileana T. Dianzo-Delgado
Servicio de Microbiología, Hospital Universitario Ramón y Cajal and Instituto Ramón y Cajal de Investigación Sanitaria (IRYCIS), Madrid, Spain
Jaime Esteban
Dept. of Clinical Microbiology, IIS-Fundación Jiménez Díaz, CIBERINFEC-CIBER de Enfermedades Infecciosas, Madrid, Spain
Stefan Fuchs
Institute of Hygiene and Medical Microbiology Medizinische Universität Innsbruck, Innsbruck, Austria
Lennart Friis-Hansen
Copenhagen University Hospital, Bispebjerg, Copenhagen, Denmark
Dept. Clinical Microbiology at Rigshospitalet, Copenhagen, Denmark
Daniel Goldenberger
University Hospital Basel, Basel, Switzerland
Andrej Golle
NZOLH Maribor, Maribor, Slovenia
Juha O. Groonroos
Varsinais-Suomen sairaanhoitopiiri, Loimaa, Finland
Ines Hoffmann
MVZ Labor Dr. Reising-Ackermann und Kollegen, Limbach Leipzig, Germany
Tomer Hoffmann
Sheba Medical Center, Ramat Gan, Israel
Harriet Hughes
University Hospital of Wales, Cardiff, Wales, United Kingdom
Marina Ivanova
East Tallinn Central Hospital, Tallin, Estonia
Peter Jezek
Regional Hospital Příbram, Příbram, Czech Republic
Gwennan Jones
University Hospital of Wales, Cardiff, Wales, United Kingdom
Zeynep Ceren Karahan
Ankara University School of Medicine Department of Medical Microbiology, Ankara, Türkiye
Cornelia Lass-Flörl
Institute of Hygiene and Medical Microbiology Medizinische Universität Innsbruck, Innsbruck, Austria
Frédéric Laurent
Hospices Civils de Lyon, Lyon, France
Laura Leach
Oxford University Hospitals (OUH), Oxford, United Kingdom
Matilde Lee Horsbøll Pedersen
Copenhagen University Hospital, Bispebjerg, Copenhagen, Denmark
Dept. Clinical Microbiology at Rigshospitalet, Copenhagen, Denmark
Caroline Loiez
Centre Hospitalier Universitaire de Lille, Lille, France
Maureen Lynch
Mater Misericordiae University Hospital, Dublin, Ireland
Robert J. Maloney
Hull University Teaching Hospitals NHS Trust, Hull, United Kingdom
Martin Marsh
Newcastle Upon Tyne Hospitals NHS Foundation Trust, Newcastle Upon Tyne, United Kingdom
Olivia Milburn
Newcastle Upon Tyne Hospitals NHS Foundation Trust, Newcastle Upon Tyne, United Kingdom
Shanine Mitchell
University Hospital of Wales, Cardiff, Wales, United Kingdom
Luke S. P. Moore
Chelsea and Westminster NHS Foundation Trust, London, United Kingdom
Lynn Moffat
NHS Greater Glasgow and Clyde, Glasgow Royal Infirmary, University of Glasgow, Glasgow, United Kingdom
Marianna Murdjeva
University Hospital “St George”, Plovdiv, Bulgaria
Michael E. Murphy
NHS Greater Glasgow and Clyde, Glasgow Royal Infirmary, University of Glasgow, Glasgow, United Kingdom
Deepa Nayar
Newcastle Upon Tyne Hospitals NHS Foundation Trust, Newcastle Upon Tyne, United Kingdom
Giacomo Nigrisoli
S. Orsola Bologna, Microbiology Unit, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy
Fionnuala O'Sullivan
Mater Misericordiae University Hospital, Dublin, Ireland
Büşra Öz
Ankara University School of Medicine Department of Medical Microbiology, Ankara, Türkiye
Teresa Peach
University Hospital of Wales, Cardiff, Wales, United Kingdom
Christina Petridou
Hampshire Hospitals NHS Foundation Trust, Winchester, UK
Mojgan Prinz
Krankenhaus Göttlicher Heiland, Vienna, Austria
Mitja Rak
Koper lab, Orthopedic Hospital Valdoltra, Valdoltra, Slovenia
Niamh Reidy
Mater Misericordiae University Hospital, Dublin, Ireland
Gian Maria Rossolini
Careggi University Hospital, Florence, Italy
Anne-Laure Roux
Hôpital Ambroise Paré, APHP, Boulogne-Billancourt, France
Patricia Ruiz-Garbajosa
CIBER de Enfermedades Infecciosas, Instituto de Salud Carlos III. Servicio de Microbiología, Hospital Universitario Ramón y Cajal and Instituto Ramón y Cajal de Investigación Sanitaria (IRYCIS), Madrid, Spain
Kordo Saeed
University Hospital Southampton NHS Foundation Trust, Southampton, United Kingdom
Llanos Salar-Vidal
Dept. of Clinical Microbiology, IIS-Fundación Jiménez Díaz, CIBERINFEC-CIBER de Enfermedades Infecciosas, Madrid, Spain
Carlos Salas Venero
Hospital Universitario Marqués de Valdecilla, Santander, Spain
Mathyruban Selvaratnam
Oxford University Hospitals (OUH), Oxford, United Kingdom
Eric Senneville
Centre Hospitalier Universitaire de Lille, Lille, France
Peter Starzengruber
Allgemeines Krankenhaus Wien, Vienna, Austria
Ben Talbot
NHS Greater Glasgow and Clyde, Glasgow Royal Infirmary, University of Glasgow, Glasgow, United Kingdom
Vanessa Taylor
University Hospital of Wales, Cardiff, Wales, United Kingdom
Rihard Trebše
Koper lab, Orthopedic Hospital Valdoltra, Valdoltra, Slovenia
Deborah Wearmouth
Hull University Teaching Hospitals NHS Trust, Hull, United Kingdom
Birgit Willinger
Allgemeines Krankenhaus Wien, Vienna, Austria
Marjan Wouthuyzen-Bakker
University Medical Center Groningen, Groningen, the Netherlands
Brianne Couturier
bioMérieux, Salt Lake City, USA
Florence Allantaz
bioMérieux, Marcy l'Etoile, France
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Céline Dupieux, Ghislaine Descours, Paul Verhoeven, Florence Grattard, Yvonne Benito, François Vandenesch, Céline Cazorla, Tristan Ferry, Sébastien Lustig, Bertrand Boyer, Sandrine Boisset, Anne Carricajo, Frédéric Laurent, and PIRLA investigator group
J. Bone Joint Infect., 9, 37–48, https://doi.org/10.5194/jbji-9-37-2024, https://doi.org/10.5194/jbji-9-37-2024, 2024
Short summary
Short summary
We define an algorithm to optimize bone and joint infection diagnosis in adults on synovial fluid samples. This prospective multi-center study included a large number of synovial fluids and compared the performance of classical culture on different media, inoculation of synovial fluid in blood culture bottles, and broad-range and specific PCR. We proposed an algorithm associating culture onto three solid media and into blood culture bottles and 16S, Staphylococcus, and Streptococcus PCR.
Jorrit Willem Adriaan Schoenmakers, Rosanne de Boer, Lilli Gard, Greetje Anna Kampinga, Marleen van Oosten, Jan Maarten van Dijl, Paulus Christiaan Jutte, and Marjan Wouthuyzen-Bakker
J. Bone Joint Infect., 8, 45–50, https://doi.org/10.5194/jbji-8-45-2023, https://doi.org/10.5194/jbji-8-45-2023, 2023
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In a first evaluation, the accuracy of a novel multiplex PCR (polymerase chain reaction) panel for rapid detection of pathogens in patients with a clinical suspicion of acute septic arthritis of native and prosthetic joints is assessed. Clear benefit is seen in patients with a suspected native septic arthritis and late acute prosthetic joint infection. This indicates that the panel allows for fast tailoring of antibiotics and may prompt the surgeon for surgical lavage in doubtful clinical cases.
Marjan Wouthuyzen-Bakker and Alexander L. Boerboom
J. Bone Joint Infect., 7, 33–34, https://doi.org/10.5194/jbji-7-33-2022, https://doi.org/10.5194/jbji-7-33-2022, 2022
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This case illustrates the clinical picture of a worn-out elbow prosthesis resulting in severe metallosis and a subsequent periprosthetic joint infection.
Karsten D. Ottink, Stefan J. Gelderman, Marjan Wouthuyzen-Bakker, Joris J. W. Ploegmakers, Andor W. J. M. Glaudemans, and Paul C. Jutte
J. Bone Joint Infect., 7, 1–9, https://doi.org/10.5194/jbji-7-1-2022, https://doi.org/10.5194/jbji-7-1-2022, 2022
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A low-grade periprosthetic joint infection (PJI) may be difficult to diagnose, and nuclear imaging could help in the diagnosis. However, its diagnostic value is unclear. We retrospectively evaluated this diagnostic value. We conclude that in patients presenting with nonspecific symptoms and a low a priori chance of PJI based on clinical evaluation, nuclear imaging is of no clear added value in diagnosing a PJI.
Simon Martin Heinrich, Parham Sendi, and Martin Clauss
J. Bone Joint Infect., 6, 423–424, https://doi.org/10.5194/jbji-6-423-2021, https://doi.org/10.5194/jbji-6-423-2021, 2021
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We report on an 83-year-old woman who had an open removal of a baker's cyst several months after total knee arthroplasty. The following wound healing problem was first misinterpreted as being superficial. With an injection of methylene blue and a contrast medium, we showed the extent of the sinus tract, proving the periprosthetic joint infection.
Karel-Jan Dag François Lensen, Rosa Escudero-Sanchez, Javier Cobo, Rihard Trebše, Camelia Gubavu, Sara Tedeschi, Jose M. Lomas, Cedric Arvieux, Dolors Rodriguez-Pardo, Massimo Fantoni, Maria Jose Garcia Pais, Francisco Jover, Mauro José Costa Salles, Ignacio Sancho, Marta Fernandez Sampedro, Alex Soriano, Marjan Wouthuyzen-Bakker, and ESCMID Study Group of Implant Associated Infections (ESGIAI)
J. Bone Joint Infect., 6, 313–319, https://doi.org/10.5194/jbji-6-313-2021, https://doi.org/10.5194/jbji-6-313-2021, 2021
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Our data suggest that, in periprosthetic joint infection (PJI) patients with a draining sinus, suppressive antibiotic treatment (SAT) can be considered on an individual basis. SAT may reduce pain and favour the closure of the sinus tract in certain individuals, but the prescription of SAT does not appear to have any influence on the prevention of prosthetic loosening and other infectious complications.
Karel-Jan Lensen, Rosa Escudero-Sanchez, Javier Cobo, Alex Soriano, and Marjan Wouthuyzen-Bakker
J. Bone Joint Infect., 6, 43–45, https://doi.org/10.5194/jbji-6-43-2020, https://doi.org/10.5194/jbji-6-43-2020, 2020
Related subject area
Subject: Microbiology of bone and joint infections | Topic: All topics
Optimized decision algorithm for the microbiological diagnosis of osteoarticular infections in adults using synovial fluid samples: a prospective study in two French hospitals including 423 samples of synovial fluid
Osteosynthesis-associated infection of the lower limbs by multidrug-resistant and extensively drug-resistant Gram-negative bacteria: a multicentre cohort study
Prosthetic joint infections caused by Mycobacterium avium complex: a series of five cases
Diagnosis of orthopaedic-implant-associated infections caused by slow-growing Gram-positive anaerobic bacteria – a clinical perspective
Céline Dupieux, Ghislaine Descours, Paul Verhoeven, Florence Grattard, Yvonne Benito, François Vandenesch, Céline Cazorla, Tristan Ferry, Sébastien Lustig, Bertrand Boyer, Sandrine Boisset, Anne Carricajo, Frédéric Laurent, and PIRLA investigator group
J. Bone Joint Infect., 9, 37–48, https://doi.org/10.5194/jbji-9-37-2024, https://doi.org/10.5194/jbji-9-37-2024, 2024
Short summary
Short summary
We define an algorithm to optimize bone and joint infection diagnosis in adults on synovial fluid samples. This prospective multi-center study included a large number of synovial fluids and compared the performance of classical culture on different media, inoculation of synovial fluid in blood culture bottles, and broad-range and specific PCR. We proposed an algorithm associating culture onto three solid media and into blood culture bottles and 16S, Staphylococcus, and Streptococcus PCR.
Efthymia Giannitsioti, Mauro José Salles, Andreas Mavrogenis, Dolors Rodriguez-Pardo, Ibai Los-Arcos, Alba Ribera, Javier Ariza, María Dolores del Toro, Sophie Nguyen, Eric Senneville, Eric Bonnet, Monica Chan, Maria Bruna Pasticci, Sabine Petersdorf, Natividad Benito, Nuala O' Connell, Antonio Blanco García, Gábor Skaliczki, Pierre Tattevin, Zeliha Kocak Tufan, Nikolaos Pantazis, Panayiotis D. Megaloikonomos, Panayiotis Papagelopoulos, Alejandro Soriano, Antonios Papadopoulos, and the ESGIAI collaborators study group
J. Bone Joint Infect., 7, 279–288, https://doi.org/10.5194/jbji-7-279-2022, https://doi.org/10.5194/jbji-7-279-2022, 2022
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Our multicentre study on a lower-limb osteosynthesis-associated infection (OAI) cohort by multidrug (MDR) and extensively drug (XDR) resistant Gram-negative bacteria found the following: implant retention with debridement was mostly performed in early OAI; 50.9 % of patients achieved remission of infection; remission reached 50 % (MDR) vs. 25 % (XDR) in early OAI and 60 % (MDR) vs. 44.4 % (XDR) in late OAI; age (> 60) and multiple surgeries were independent factors influencing lack of remission.
Katharine Dobos, Gina A. Suh, Aaron J. Tande, and Shanthi Kappagoda
J. Bone Joint Infect., 7, 137–141, https://doi.org/10.5194/jbji-7-137-2022, https://doi.org/10.5194/jbji-7-137-2022, 2022
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This paper describes five cases of prosthetic joint infection (PJI) caused by Mycobacterium avium complex (MAC). Infections occurred in both immune competent and immunosuppressed patients. Interestingly, using the Musculoskeletal Infection Society diagnostic criteria for PJI may miss some cases of MAC PJI. Treatment courses and outcomes are described.
Diana Salomi Ponraj, Thomas Falstie-Jensen, Nis Pedersen Jørgensen, Christen Ravn, Holger Brüggemann, and Jeppe Lange
J. Bone Joint Infect., 6, 367–378, https://doi.org/10.5194/jbji-6-367-2021, https://doi.org/10.5194/jbji-6-367-2021, 2021
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Implant-associated infections (IAIs) in orthopaedic surgery are associated with high morbidity and mortality. Slow-growing anaerobic bacteria are increasingly being recognized as potential causative agents in such infections, but their diagnosis is difficult. The purpose of this review is to summarize the current knowledge of IAIs with these bacteria. In particular, the review gives an overview of the current methodology in the diagnosis of such infections, to serve as a guide for clinicians.
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Short summary
This study conducted in multiple sites across Europe aimed to evaluate the BIOFIRE Joint Infection (JI) Panel, a new technology that uses multiplex PCR to detect microorganisms in synovial fluid of patients with suspicion of joint infections in 1 h, in comparison with synovial fluid culture. Results showed an overall agreement of 85 % to 88.4 % between the two methods. The JI Panel detected additional organisms, and the positive user experience highlights its clinical significance.
This study conducted in multiple sites across Europe aimed to evaluate the BIOFIRE Joint...
