Articles | Volume 9, issue 6
https://doi.org/10.5194/jbji-9-261-2024
https://doi.org/10.5194/jbji-9-261-2024
Original full-length article
 | 
07 Nov 2024
Original full-length article |  | 07 Nov 2024

The immediate ex vivo covering and filling characteristics of antibiotic-loaded resorbable calcium sulfate paste around intramedullary nails

Amber A. Hamilton, Jidapa Wongcharoenwatana, Jason S. Hoellwarth, Austin T. Fragomen, S. Robert Rozbruch, and Taylor J. Reif

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Cited articles

Abalkhail, T. B., Elhessy, A. H., and Conway, J. D.: Removal of Antibiotic Cement-Coated Interlocking Nails, J. Orthop. Trauma, 36, 317–320, https://doi.org/10.1097/BOT.0000000000002287, 2022. 
Abulaiti, A., Yilihamu, Y., Yasheng, T., Alike, Y., and Yusufu, A.: The psychological impact of external fixation using the Ilizarov or Orthofix LRS method to treat tibial osteomyelitis with a bone defect, Injury, 48, 2842–2846, https://doi.org/10.1016/j.injury.2017.10.036, 2017. 
Alt, V.: Treatment of an infected nonunion with additional fresh fracture of the femur with a silver-coated intramedullary nail: A case report, Trauma Case Reports, 39, 10064, https://doi.org/10.1016/j.tcr.2022.100641, 2022. 
Amin, T. J., Lamping, J. W., Hendricks, K. J., and McIff, T. E.: Increasing the Elution of Vancomycin from High-Dose Antibiotic-Loaded Bone Cement: A Novel Preparation Technique, J. Bone Joint Surg. Am., 94, 1946–1951, https://doi.org/10.2106/JBJS.L.00014, 2012. 
Anagnostakos, K. and Meyer, C.: Antibiotic Elution from Hip and Knee Acrylic Bone Cement Spacers: A Systematic Review, BioMed Res. Int., 2017, 1–7, https://doi.org/10.1155/2017/4657874, 2017. 
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Short summary
Implant-related osteomyelitis is common in orthopedics. Absorbable antibiotic-loaded calcium sulfate (ACS) is an alternative to nonabsorbable antibiotic depot options for osteomyelitis and fracture-related infections. This study aims to evaluate intramedullary canal filling and coating characteristics of ACS around tibial nails using a tibia SAWBONES model. This research was done to better understand the potential utility of ACS in situations requiring fixation in the setting of local infection.