Articles | Volume 9, issue 6
https://doi.org/10.5194/jbji-9-261-2024
© Author(s) 2024. This work is distributed under
the Creative Commons Attribution 4.0 License.
the Creative Commons Attribution 4.0 License.
https://doi.org/10.5194/jbji-9-261-2024
© Author(s) 2024. This work is distributed under
the Creative Commons Attribution 4.0 License.
the Creative Commons Attribution 4.0 License.
The immediate ex vivo covering and filling characteristics of antibiotic-loaded resorbable calcium sulfate paste around intramedullary nails
Limb Lengthening and Complex Reconstruction Service, Hospital for Special Surgery, New York, NY 10021, USA
Department of Orthopedic Surgery, Weill Cornell Medical College, New York, NY 10021, USA
Jidapa Wongcharoenwatana
Limb Lengthening and Complex Reconstruction Service, Hospital for Special Surgery, New York, NY 10021, USA
Jason S. Hoellwarth
Limb Lengthening and Complex Reconstruction Service, Hospital for Special Surgery, New York, NY 10021, USA
Department of Orthopedic Surgery, Weill Cornell Medical College, New York, NY 10021, USA
Austin T. Fragomen
Limb Lengthening and Complex Reconstruction Service, Hospital for Special Surgery, New York, NY 10021, USA
Department of Orthopedic Surgery, Weill Cornell Medical College, New York, NY 10021, USA
S. Robert Rozbruch
Limb Lengthening and Complex Reconstruction Service, Hospital for Special Surgery, New York, NY 10021, USA
Department of Orthopedic Surgery, Weill Cornell Medical College, New York, NY 10021, USA
Taylor J. Reif
Limb Lengthening and Complex Reconstruction Service, Hospital for Special Surgery, New York, NY 10021, USA
Department of Orthopedic Surgery, Weill Cornell Medical College, New York, NY 10021, USA
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Shafaf Hasin Alam, Jason S. Hoellwarth, Kevin Tetsworth, Atiya Oomatia, Tristen N. Taylor, and Munjed Al Muderis
J. Bone Joint Infect., 9, 49–57, https://doi.org/10.5194/jbji-9-49-2024, https://doi.org/10.5194/jbji-9-49-2024, 2024
Short summary
Short summary
Osseointegration is a highly enabling reconstruction for patients with limb loss. However, infection can occur. There are currently poor diagnostic criteria for infection, and patients may be brought for surgery too much or too little. The study proposes an algorithm based on history, clinical, and laboratory data to predict the chance of culture-positive deep infection.
Jason S. Hoellwarth, Taylor J. Reif, Michael W. Henry, Andy O. Miller, Austin C. Kaidi, and S. Robert Rozbruch
J. Bone Joint Infect., 7, 155–162, https://doi.org/10.5194/jbji-7-155-2022, https://doi.org/10.5194/jbji-7-155-2022, 2022
Short summary
Short summary
The stoma for transcutaneous osseointegration carries a permanent source of bacterial ingress and infection. The value and role of intraoperative cultures to detect latent bacterial contamination or infection with targeted postoperative antibiotics has not been previously investigated. We compared two cohorts, 8 patients with unexpected positive cultures and 22 patients with negative intraoperative cultures, and found positive cultures do not appear to portend future infectious events.
Emilie-Ann Downey, Kayla M. Jaime, Taylor J. Reif, Asim M. Makhdom, S. Robert Rozbruch, and Austin T. Fragomen
J. Bone Joint Infect., 7, 101–107, https://doi.org/10.5194/jbji-7-101-2022, https://doi.org/10.5194/jbji-7-101-2022, 2022
Short summary
Short summary
The use of dissolving local antibiotic delivery systems in orthopedic surgery is improving the way we treat infection. Early analysis of a small cohort suggests that antibiotic-loaded calcium sulfate-coated interlocking intramedullary nails (CS-IMN) are safe and may be as effective as the more established method for infection eradication. Future studies with larger cohorts of patients will be required to confirm these findings.
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Short summary
Implant-related osteomyelitis is common in orthopedics. Absorbable antibiotic-loaded calcium sulfate (ACS) is an alternative to nonabsorbable antibiotic depot options for osteomyelitis and fracture-related infections. This study aims to evaluate intramedullary canal filling and coating characteristics of ACS around tibial nails using a tibia SAWBONES model. This research was done to better understand the potential utility of ACS in situations requiring fixation in the setting of local infection.
Implant-related osteomyelitis is common in orthopedics. Absorbable antibiotic-loaded calcium...