Journal of Bone and Joint Infection
Journal of Bone and Joint Infection
JBJI
Articles | Volume 9, issue 5
Articles | Volume 9, issue 5
https://doi.org/10.5194/jbji-9-249-2024
© Author(s) 2024. This work is distributed under
the Creative Commons Attribution 4.0 License.
https://doi.org/10.5194/jbji-9-249-2024
© Author(s) 2024. This work is distributed under
the Creative Commons Attribution 4.0 License.
Articles | Volume 9, issue 5
Review
 | 
31 Oct 2024
Review |  | 31 Oct 2024

Exploring the potential of naturally occurring antimicrobials for managing orthopedic-device-related infections

Baixing Chen, T. Fintan Moriarty, Hans Steenackers, Georges F. Vles, Jolien Onsea, Thijs Vackier, Isabel Spriet, Rob Lavigne, R. Geoff Richards, and Willem-Jan Metsemakers

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Abedon, S. T., Kuhl, S. J., Blasdel, B. G., and Kutter, E. M.: Phage treatment of human infections, Bacteriophage, 1, 66–85, https://doi.org/10.4161/bact.1.2.15845, 2011. 
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Aunon, A., Tovar-Bazaga, M., Blanco-Garcia, A., Garcia-Canete, J., Parron, R., and Esteban, J.: Does a New Antibiotic Scheme Improve the Outcome of Staphylococcus aureus-Caused Acute Prosthetic Joint Infections (PJI) Treated with Debridement, Antibiotics and Implant Retention (DAIR)?, Antibiotics (Basel), 11, 922, https://doi.org/10.3390/antibiotics11070922, 2022. 
Benito, N., Franco, M., Ribera, A., Soriano, A., Rodriguez-Pardo, D., Sorli, L., Fresco, G., Fernandez-Sampedro, M., Dolores Del Toro, M., Guio, L., Sanchez-Rivas, E., Bahamonde, A., Riera, M., Esteban, J., Baraia-Etxaburu, J. M., Martinez-Alvarez, J., Jover-Saenz, A., Duenas, C., Ramos, A., Sobrino, B., Euba, G., Morata, L., Pigrau, C., Coll, P., Mur, I., Ariza, J., and the REIPI (Spanish Network for Research in Infectious Disease) Group for the Study of Prosthetic Joint Infections: Time trends in the aetiology of prosthetic joint infections: a multicentre cohort study, Clin. Microbiol. Infect., 22, 732 e731–738, https://doi.org/10.1016/j.cmi.2016.05.004, 2016. 
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Our research explores natural antimicrobials to combat orthopedic-device-related infections, a challenging issue due to antibiotic resistance. We reviewed agents from bacteria, fungi, viruses, animals, plants and minerals, evaluating their effectiveness and synergy with traditional antibiotics. Our findings suggest these natural alternatives could revolutionize infection management in orthopedic patients, offering new hope for reducing antibiotic resistance and improving treatment outcomes.
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