Articles | Volume 9, issue 5
https://doi.org/10.5194/jbji-9-249-2024
https://doi.org/10.5194/jbji-9-249-2024
Review
 | 
31 Oct 2024
Review |  | 31 Oct 2024

Exploring the potential of naturally occurring antimicrobials for managing orthopedic-device-related infections

Baixing Chen, T. Fintan Moriarty, Hans Steenackers, Georges F. Vles, Jolien Onsea, Thijs Vackier, Isabel Spriet, Rob Lavigne, R. Geoff Richards, and Willem-Jan Metsemakers

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Cited articles

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Akita, S., Namiki, T., Kawasaki, Y., Rikihisa, N., Ogata, H., Tokumoto, H., Tezuka, T., Kubota, Y., Kuriyama, M., Nakamura, M., and Mitsukawa, N.: The beneficial effect of traditional Japanese herbal (Kampo) medicine, Hochu-ekki-to (Bu-Zhong-Yi-Qi-Tang), for patients with chronic wounds refractory to conventional therapies: A prospective, randomized trial, Wound Repair Regen., 27, 672–679, https://doi.org/10.1111/wrr.12753, 2019. 
Aunon, A., Tovar-Bazaga, M., Blanco-Garcia, A., Garcia-Canete, J., Parron, R., and Esteban, J.: Does a New Antibiotic Scheme Improve the Outcome of Staphylococcus aureus-Caused Acute Prosthetic Joint Infections (PJI) Treated with Debridement, Antibiotics and Implant Retention (DAIR)?, Antibiotics (Basel), 11, 922, https://doi.org/10.3390/antibiotics11070922, 2022. 
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Short summary
Our research explores natural antimicrobials to combat orthopedic-device-related infections, a challenging issue due to antibiotic resistance. We reviewed agents from bacteria, fungi, viruses, animals, plants and minerals, evaluating their effectiveness and synergy with traditional antibiotics. Our findings suggest these natural alternatives could revolutionize infection management in orthopedic patients, offering new hope for reducing antibiotic resistance and improving treatment outcomes.