Articles | Volume 9, issue 3
https://doi.org/10.5194/jbji-9-167-2024
https://doi.org/10.5194/jbji-9-167-2024
Case report
 | 
13 Jun 2024
Case report |  | 13 Jun 2024

Ureaplasma urealyticum osteomyelitis of the greater trochanter in a patient with multiple sclerosis using ocrelizumab – a case report

Fred Ruythooren, Stijn Ghijselings, Melissa Depypere, Willem-Jan Metsemakers, Liesbet Henckaerts, Nathalie Noppe, and Georges Vles

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Cited articles

Cunliffe, N. A., Fergusson, S., Davidson, F., Lyon, A., and Ross, P. W.: Comparison of culture with the polymerase chain reaction for detection of Ureaplasma urealyticum in endotracheal aspirates of preterm infants, J. Med. Microbiol., 45, 27–30, https://doi.org/10.1099/00222615-45-1-27, 1996. 
El Zein, S., Garvey, T., Amin, S., and Tande, A. J.: Native joint polyarticular septic arthritis secondary to disseminated Ureaplasma urealyticum infection in a patient on rituximab therapy with hypogammaglobulinemia: A Case Report, IDCases, 32, e01744, https://doi.org/10.1016/j.idcr.2023.e01744, 2023. 
Fernández, J., Karau, M. J., Cunningham, S. A., Greenwood-Quaintance, K. E., and Patel, R.: Antimicrobial susceptibility and clonality of clinical Ureaplasma isolates in the United States, Antimicrob. Agents Chemother., 60, 4793–4798, https://doi.org/10.1128/AAC.00671-16, 2016. 
Friberg, J.: Diagnosis of genital Mycoplasma and Ureaplasma infections, J. Reprod. Med., 30, 258–261, 1985. 
Furr, P. M., Taylor-Robinson, D., and Webster, A. D.: Mycoplasmas and ureaplasmas in patients with hypogammaglobulinaemia and their role in arthritis: microbiological observations over twenty years., Ann. Rheum. Dis., 53, 183–187, https://doi.org/10.1136/ard.53.3.183, 1994. 
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Short summary
The article examines a unique case of Ureaplasma urealyticum causing osteomyelitis in the greater trochanter of a 26-year-old male treated with ocrelizumab for multiple sclerosis. It emphasizes the necessity of a multidisciplinary approach and advanced PCR diagnostics to manage such rare opportunistic infections effectively, highlighting the challenges faced due to the immunosuppressive nature of monoclonal antibody therapies of this kind.