Articles | Volume 9, issue 2
https://doi.org/10.5194/jbji-9-121-2024
https://doi.org/10.5194/jbji-9-121-2024
Brief report
 | 
22 Mar 2024
Brief report |  | 22 Mar 2024

Local delivery of linezolid in the treatment of complex orthopedic bone and joint infections in patients with vancomycin allergy: a case series

Abhijith Annasamudram, Aja Janyavula, Ahmed H. Elhessy, Raj Krishna Shrestha, Martin Gesheff, and Janet D. Conway

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Subject: Anti-bacterial agents | Topic: Local administration
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Cited articles

Alvarez-Arango, S., Yerneni, S., Tang, O., Zhou, L., Mancini, C. M., Blackley, S. V., Keet, C. A., and Blumenthal, K. G.: Vancomycin hypersensitivity reactions documented in electronic health records, J. Aller. Cl. Imm.-Pract., 9, 906–912, 2021. 
Anagnostakos, K., Kelm, J., Grün, S., Schmitt, E., Jung, W., and Swoboda, S.: Antimicrobial properties and elution kinetics of linezolid-loaded hip spacers in vitro, J. Biomed. Mater. Res. B, 87, 173–178, 2008. 
Anguita-Alonso, P., Rouse, M. S., Piper, K. E., Jacofsky, D. J., Osmon, D. R., and Patel, R.: Comparative study of antimicrobial release kinetics from polymethylmethacrylate, Clin. Orthop. Relat. R., 445, 239–244, 2006. 
Balato, G., Roscetto, E., Vollaro, A., Galasso, O., Gasparini, G., Ascione, T., Catania, M. R., and Mariconda, M.: Bacterial biofilm formation is variably inhibited by different formulations of antibiotic-loaded bone cement in vitro, Knee Surg. Sport. Tr. A., 27, 1943–1952, 2019. 
Bassetti, M., Vitale, F., Melica, G., Righi, E., Di Biagio, A., Molfetta, L., Pipino, F., Cruciani, M., and Bassetti, D.: Linezolid in the treatment of Gram-positive prosthetic joint infections, J. Antimicrob. Chemoth., 55, 387–390, 2005. 
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Short summary
A retrospective study on 13 patients treated with linezolid-loaded spacers for bone and joint infections revealed that 9 patients achieved successful limb salvage and remained infection-free after an average follow-up of 55.5 months. Linezolid-loaded bone cement is a viable option for managing chronic bone and joint infections, especially in patients with vancomycin allergy.