Journal of Bone and Joint Infection
Journal of Bone and Joint Infection
JBJI
Articles | Volume 9, issue 2
Articles | Volume 9, issue 2
https://doi.org/10.5194/jbji-9-121-2024
© Author(s) 2024. This work is distributed under
the Creative Commons Attribution 4.0 License.
https://doi.org/10.5194/jbji-9-121-2024
© Author(s) 2024. This work is distributed under
the Creative Commons Attribution 4.0 License.
Articles | Volume 9, issue 2
Brief report
 | 
22 Mar 2024
Brief report |  | 22 Mar 2024

Local delivery of linezolid in the treatment of complex orthopedic bone and joint infections in patients with vancomycin allergy: a case series

Abhijith Annasamudram, Aja Janyavula, Ahmed H. Elhessy, Raj Krishna Shrestha, Martin Gesheff, and Janet D. Conway

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Latest update: 30 Jul 2026
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Short summary
A retrospective study on 13 patients treated with linezolid-loaded spacers for bone and joint infections revealed that 9 patients achieved successful limb salvage and remained infection-free after an average follow-up of 55.5 months. Linezolid-loaded bone cement is a viable option for managing chronic bone and joint infections, especially in patients with vancomycin allergy.
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