Articles | Volume 8, issue 2
https://doi.org/10.5194/jbji-8-91-2023
https://doi.org/10.5194/jbji-8-91-2023
Original full-length article
 | 
22 Mar 2023
Original full-length article |  | 22 Mar 2023

The efficacy of antibiotic-impregnated calcium sulfate (AICS) in the treatment of infected non-union and fracture-related infection: a systematic review

Connor C. Jacob, Jad H. Daw, and Juan Santiago-Torres

Related subject area

Subject: Anti-bacterial agents | Topic: Local administration
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Cited articles

Aquino-Martínez, R., Angelo, A. P., and Pujol, F. V.: Calcium-containing scaffolds induce bone regeneration by regulating mesenchymal stem cell differentiation and migration, Stem Cell Res. Ther., 8, 265, https://doi.org/10.1186/s13287-017-0713-0, 2017. 
Boyle, K. K., Sosa, B., Osagie, L., Turajane, K., Bostrom, M. P. G., and Yang, X.: Vancomycin-laden calcium phosphate-calcium sulfate composite allows bone formation in a rat infection model, PloS One, 14, e0222034, https://doi.org/10.1371/journal.pone.0222034, 2019. 
Cai, X., Han, K., Cong, X., Cai, J., Tong, D., Han, D., Wang, Y., and Yu, B.: The use of calcium sulfate impregnated with vancomycin in the treatment of open fractures of long bones: a preliminary study, Orthopedics, 33, 152–157, https://doi.org/10.3928/01477447-20100129-17, 2010. 
Cheung, E., Baerlocher, M. O., Asch, M., and Myers, A.: Venous access: a practical review for 2009, Can. Fam. Physician Med. Fam. Can., 55, 494–496, 2009. 
Coetzee, A. S.: Regeneration of bone in the presence of calcium sulfate, Arch. Otolaryngol. Chic. Ill, 106, 405–409, https://doi.org/10.1001/archotol.1980.00790310029007, 1980. 
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Short summary
Sometimes after surgery to repair an injured bone or joint, infection can cause the bone to heal improperly. Surgeons use calcium sulfate to prevent infections in joints after surgery. Calcium sulfate can be impregnated with antibiotics and placed inside the joint, where the bloodstream often cannot deliver intravenous or oral antibiotics effectively. We reviewed 20 years of studies of the effectiveness of calcium sulfate and found high rates of healing and infection eradication.