Articles | Volume 8, issue 5
https://doi.org/10.5194/jbji-8-209-2023
© Author(s) 2023. This work is distributed under
the Creative Commons Attribution 4.0 License.
the Creative Commons Attribution 4.0 License.
https://doi.org/10.5194/jbji-8-209-2023
© Author(s) 2023. This work is distributed under
the Creative Commons Attribution 4.0 License.
the Creative Commons Attribution 4.0 License.
Should treatment decisions in septic arthritis of the native hip joint be based on the route of infection?
Fred Ruythooren
CORRESPONDING AUTHOR
Department of Orthopaedic Surgery, University Hospitals Leuven –
Gasthuisberg, Leuven, Belgium
Institute for Orthopaedic Research and Training (IORT), Catholic
University Leuven, Leuven, Belgium
Stijn Ghijselings
Department of Orthopaedic Surgery, University Hospitals Leuven –
Gasthuisberg, Leuven, Belgium
Institute for Orthopaedic Research and Training (IORT), Catholic
University Leuven, Leuven, Belgium
Jordi Cools
Department of Orthopaedic Surgery, University Hospitals Leuven –
Gasthuisberg, Leuven, Belgium
Institute for Orthopaedic Research and Training (IORT), Catholic
University Leuven, Leuven, Belgium
Melissa Depypere
Department of Laboratory Medicine, University Hospitals Leuven –
Gasthuisberg, Leuven, Belgium
Paul De Munter
Department of General Internal Medicine, University Hospitals Leuven – Gasthuisberg, Leuven, Belgium
Department of Microbiology, Immunology and Transplantation, Laboratory for Clinical Infectious and Inflammatory Disorders, KU Leuven, Leuven, Belgium
Willem-Jan Metsemakers
Department of Traumatology, University Hospitals Leuven –
Gasthuisberg, Belgium
Department of Development and Regeneration, KU Leuven, Leuven,
Belgium
Georges Vles
CORRESPONDING AUTHOR
Department of Orthopaedic Surgery, University Hospitals Leuven –
Gasthuisberg, Leuven, Belgium
Institute for Orthopaedic Research and Training (IORT), Catholic
University Leuven, Leuven, Belgium
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The article examines a unique case of Ureaplasma urealyticum causing osteomyelitis in the greater trochanter of a 26-year-old male treated with ocrelizumab for multiple sclerosis. It emphasizes the necessity of a multidisciplinary approach and advanced PCR diagnostics to manage such rare opportunistic infections effectively, highlighting the challenges faced due to the immunosuppressive nature of monoclonal antibody therapies of this kind.
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Cited articles
Anagnostakos, K., Duchow, L., and Koch, K.: Two-stage protocol and spacer
implantation in the treatment of destructive septic arthritis of the hip
joint, Arch. Orthop. Trauma Surg., 136, 899–906,
https://doi.org/10.1007/s00402-016-2455-3, 2016.
Balato, G., de Matteo, V., Ascione, T., de Giovanni, R., Marano, E., Rizzo,
M., and Mariconda, M.: Management of septic arthritis of the hip joint in
adults. A systematic review of the literature, BMC Musculoskelet. Disord., 22,
1006, https://doi.org/10.1186/s12891-021-04843-z, 2021.
Bauer, T., Lacoste, S., Lhotellier, L., Mamoudy, P., Lortat-Jacob, A., and
Hardy, P.: Arthroplasty following a septic arthritis history: A 53 cases
series, Orthop. Traumatol.-Sur., 96, 840–843,
https://doi.org/10.1016/j.otsr.2010.06.009, 2010.
Baumgarten, M., Margolis, D. J., Localio, A. R., Kagan, S. H., Lowe, R. A.,
Kinosian, B., Holmes, J. H., Abbuhl, S. B., Kavesh, W., and Ruffin, A.:
Pressure Ulcers Among Elderly Patients Early in the Hospital Stay,
J. Gerontol., 61, 749–754,
https://doi.org/10.1093/gerona/61.7.749, 2006.
Bettencourt, J. W., Wyles, C. C., Osmon, D. R., Hanssen, A. D., Berry, D.
J., and Abdel, M. P.: Outcomes of primary total hip arthroplasty following
septic arthritis of the hip, Bone Joint J., 104-B, 227–234,
https://doi.org/10.1302/0301-620X.104B2.BJJ-2021-1209.R1, 2022.
Blitzer, C. M.: Arthroscopic management of septic arthritis of the hip,
Arthroscopy, 9, 414–416, https://doi.org/10.1016/S0749-8063(05)80315-9,
1993.
Chen, C. E., Wang, J. W., and Juhn, R. J.: Total hip arthroplasty for
primary septic arthritis of the hip in adults, Int. Orthop., 32, 573–580,
https://doi.org/10.1007/s00264-007-0366-1, 2008.
Crespo, A., Stevens, N. M., Chiu, E., Pham, V., and Leucht, P.: Incidence of
Osteomyelitis in Sacral Decubitus Ulcers and Recommendations for Management,
JBJS Rev., 8, e0141, https://doi.org/10.2106/JBJS.RVW.19.00187, 2020.
D'Angelo, F., Monestier, L., and Zagra, L.: Active septic arthritis of the
hip in adults: what's new in the treatment? A systematic review, EFORT Open
Rev., 6, 164–172, https://doi.org/10.1302/2058-5241.6.200082, 2021.
DeVivo, M. J.: Epidemiology of traumatic spinal cord injury: trends and
future implications, Spinal Cord, 50, 365–372,
https://doi.org/10.1038/sc.2011.178, 2012.
Fukushima, K., Uekusa, Y., Koyama, T., Ohashi, Y., Uchiyama, K., Takahira,
N., and Takaso, M.: Efficacy and safety of arthroscopic treatment for native
acute septic arthritis of the hip joint in adult patients, BMC Musculoskelet. Disord., 22, 318, https://doi.org/10.1186/s12891-021-04195-8, 2021.
George, J., Chandy, V. J., Premnath, J., Hariharan, T. D., Oommen, A.,
Balaji, V., and Poonnoose, P.: Microbiological profile of septic arthritis
in adults: Lessons learnt and treatment strategies, Indian J. Med. Microbiol.,
37, 29–33, https://doi.org/10.4103/ijmm.IJMM_19_134, 2019.
Hipfl, C., Karczewski, D., Oronowicz, J., Pumberger, M., Perka, C., and
Hardt, S.: Total hip arthroplasty for destructive septic arthritis of the
hip using a two-stage protocol without spacer placement, Arch. Orthop. Trauma Surg., 143, 19–28, https://doi.org/10.1007/s00402-021-03981-2, 2023.
Huang, T.-W., Huang, K.-C., Lee, P.-C., Tai, C.-L., and Hsieh, P.-H.:
Encouraging Outcomes of Staged, Uncemented Arthroplasty With Short-Term
Antibiotic Therapy for Treatment of Recalcitrant Septic Arthritis of the
Native Hip, J. Trauma Acute Care, 68, 965–969, https://doi.org/10.1097/TA.0b013e3181af6e70, 2010.
Huang, Y.-C., Ho, C.-H., Lin, Y.-J., Chen, H.-J., Liu, S.-Y., Wang, C.-L.,
Lin, C.-H., Wang, J.-J., and Chien, C.-C.: Site-specific mortality in native
joint septic arthritis: a national population study, Rheumatology, 59,
3826–3833, https://doi.org/10.1093/rheumatology/keaa162, 2020.
Hunter, J. G., Gross, J. M., Dahl, J. D., Amsdell, S. L., and Gorczyca, J.
T.: Risk Factors for Failure of a Single Surgical Debridement in Adults with
Acute Septic Arthritis, J. Bone Surg., 97, 558–564, https://doi.org/10.2106/JBJS.N.00593, 2015.
Kao, F.-C., Hsu, Y.-C., Liu, P.-H., Tu, Y.-K., and Jou, I.-M.: High 2-year
mortality and recurrent infection rates after surgical treatment for primary
septic arthritis of the hip in adult patients: An observational study,
Medicine, 98, e16765, https://doi.org/10.1097/MD.0000000000016765, 2019.
Kennedy, N., Chambers, S. T., Nolan, I., Gallagher, K., Werno, A., Browne,
M., and Stamp, L. K.: Native Joint Septic Arthritis: Epidemiology, Clinical
Features, and Microbiological Causes in a New Zealand Population, J.
Rheumatol., 42, 2392–2397, https://doi.org/10.3899/jrheum.150434, 2015.
Khazi, Z. M., Cates, W. T., An, Q., Duchman, K. R., Wolf, B. R., and
Westermann, R. W.: Arthroscopy Versus Open Arthrotomy for Treatment of
Native Hip Septic Arthritis: An Analysis of 30-Day Complications,
Arthroscopy, 36, 1048–1052, https://doi.org/10.1016/j.arthro.2019.10.008,
2020.
Kim, B., Boukebous, B., White, D., and Baker, J. F.: Septic arthritis of the
native hip joint: a multi-pattern, multi-outcome disease, Eur. J.
Orthop. Surg. Tr., 33, 2587–2594,
https://doi.org/10.1007/s00590-023-03477-2, 2023.
Lee, Y.-K., Park, K.-S., Ha, Y.-C., and Koo, K.-H.: Arthroscopic treatment
for acute septic arthritis of the hip joint in adults, Knee Surgery, Sports
Traumatology, Arthroscopy, 22, 942–945,
https://doi.org/10.1007/s00167-012-2283-0, 2014.
Le Fort, M., Rome-Saulnier, J., Lejeune, F., Bellier-Waast, F., Touchais,
S., Kieny, P., Duteille, F., and Perrouin-Verbe, B.: Sepsis of the hip due
to pressure sore in spinal cord injured patients: advocacy for a one-stage
surgical procedure, Spinal Cord, 53, 226–231,
https://doi.org/10.1038/sc.2014.170, 2015.
Lum, Z. C., Shieh, A. K., and Meehan, J. P.: Native Adult Hip with Bacterial
Septic Arthritis, JBJS Rev., 6, e2, https://doi.org/10.2106/JBJS.RVW.17.00211, 2018.
Mabille, C., El Samad, Y., Joseph, C., Brunschweiler, B., Goeb, V., Grados,
F., and Lanoix, J. P.: Medical versus surgical treatment in native hip and
knee septic arthritis, Infect. Dis. Now, 51, 164–169,
https://doi.org/10.1016/j.medmal.2020.04.019, 2021.
Manadan, A. M. and Block, J. A.: Daily needle aspiration versus surgical
lavage for the treatment of bacterial septic arthritis in adults, Am. J. Ther.,
11, 412–415, https://doi.org/10.1097/01.mph.0000087296.80768.1e, 2004.
Margaretten, M. E., Kohlwes, J., Moore, D., and Bent, S.: Does This Adult
Patient Have Septic Arthritis?, JAMA, 297, 1478–1488,
https://doi.org/10.1001/jama.297.13.1478, 2007.
Mathews, C. J., Kingsley, G., Field, M., Jones, A., Weston, V. C., Phillips,
M., Walker, D., and Coakley, G.: Management of septic arthritis: a
systematic review, Ann. Rheum. Dis., 84, 265–270,
https://doi.org/10.1136/ard.2006.058909, 2007.
Mathews, C. J., Weston, V. C., Jones, A., Field, M., and Coakley, G.:
Bacterial septic arthritis in adults, Lancet, 375, 846–855,
https://doi.org/10.1016/S0140-6736(09)61595-6, 2010.
Matthews, P. C., Dean, B. J. F., Medagoda, K., Gundle, R., Atkins, B. L.,
Berendt, A. R., and Byren, I.: Native hip joint septic arthritis in 20
adults: Delayed presentation beyond three weeks predicts need for excision
arthroplasty, J. Infection, 57, 185–190,
https://doi.org/10.1016/j.jinf.2008.07.001, 2008.
Mue, D., Salihu, M., Awonusi, F., Yongu, W., Kortor, J., and Elachi, C.: The
epidemiology and outcome of acute septic arthritis: a hospital based study,
J. West Afr. Coll. Surg., 3, 40–52, 2014.
Papanna, M. C., Chebbout, R., Buckley, S., Stockley, I., and Hamer, A.:
Infection and failure rates following total hip arthroplasty for septic
arthritis: a case-controlled study, HIP Int., 28, 63–67,
https://doi.org/10.5301/hipint.5000538, 2017.
Petersen, S. K., Hansen, I. M. J., and Andreasen, R. A.: Low frequency of
septic arthritis after arthrocentesis and intra-articular glucocorticoid
injection, Scand. J. Rheumatol., 48, 393–397,
https://doi.org/10.1080/03009742.2019.1584329, 2019.
Portier, E., Zeller, V., Kerroumi, Y., Heym, B., Marmor, S., and Chazerain,
P.: Arthroplasty after septic arthritis of the native hip and knee:
retrospective analysis of 49 joints, J. Bone Joint Infect., 7, 81–90,
https://doi.org/10.5194/jbji-7-81-2022, 2022.
Ravn, C., Neyt, J., Benito, N., Abreu, M. A., Achermann, Y., Bozhkova, S., Coorevits, L., Ferrari, M. C., Gammelsrud, K. W., Gerlach, U.-J., Giannitsioti, E., Gottliebsen, M., Jørgensen, N. P., Madjarevic, T., Marais, L., Menon, A., Moojen, D. J., Pääkkönen, M., Pokorn, M., Pérez-Prieto, D., Renz, N., Saavedra-Lozano, J., Sabater-Martos, M., Sendi, P., Tevell, S., Vogely, C., Soriano, A., and the SANJO guideline group: Guideline for management of septic arthritis in native joints (SANJO), J. Bone Joint Infect., 8, 29–37, https://doi.org/10.5194/jbji-8-29-2023, 2023.
R Core Team: R: A language and environment for statistical computing, R Foundation for Statistical Computing, Vienna, Austria, https://www.R-project.org/ (last access: 26 February 2023), 2015.
Ross, J. J.: Septic Arthritis of Native Joints, Infect. Dis. Clin. North Am.,
31, 203–218, https://doi.org/10.1016/j.idc.2017.01.001,
2017.
Ruythooren, F.: SA native hip joints, V1, Mendeley Data [data set], https://doi.org/10.17632/3gd63zcgnj.1, 2023.
Selton-Suty, C., Célard, M., Le Moing, V., Doco-Lecompte, T., Chirouze, C., Iung, B., Strady, C., Revest, M., Vandenesch, F., Bouvet, A., Delahaye, F., Alla, F., Duval, X., Hoen, B., on behalf of the AEPEI Study Groupa:
Preeminence of Staphylococcus aureus in Infective Endocarditis: A 1-Year
Population-Based Survey, Clin. Infect. Dis., 54, 1230–1239,
https://doi.org/10.1093/cid/cis199, 2012.
Shirtliff, M. E. and Mader, J. T.: Acute septic arthritis, Clin. Microbiol. Rev., 15, 527–44,
https://doi.org/10.1128/CMR.15.4.527-544.2002, 2002.
Suda, A. J. and Heppert, V.: Vastus lateralis muscle flap for infected hips
after resection arthroplasty, J. Bone Joint Surg. Br., 92-B, 1654–1658,
https://doi.org/10.1302/0301-620X.92B12.25212, 2010.
Tan, T., Xu, C., Kuo, F.-C., Ghanem, E., Higuera, C., and Parvizi, J.: Risk
Factors for Failure and Optimal Treatment of Total Joint Arthroplasty for
Septic Arthritis, J. Arthroplasty, 36, 892–896,
https://doi.org/10.1016/j.arth.2020.09.020, 2021.
Vassallo, C., Borg, A. A., Farrugia, D., and Mercieca, C.: The epidemiology
and outcomes of septic arthritis in the Maltese Islands: A hospital-based
retrospective cohort study, Mediterr. J. Rheumatol., 31, 195–205,
https://doi.org/10.31138/mjr.31.2.195, 2020.
Whitney, J., Phillips, L., Aslam, R., Barbul, A., Gottrup, F., Gould, L.,
Robson, M. C., Rodeheaver, G., Thomas, D., and Stotts, N.: Guidelines for
the treatment of pressure ulcers, Wound Repair Regen., 14,
663–679, https://doi.org/10.1111/j.1524-475X.2006.00175.x,
2006.
Short summary
A total of 41 patients who underwent surgical treatment for septic arthritis (SA) of the native hip were studied. We show that patients with SA of the native hip can be divided in three distinct clinical subgroups based on route of infection. Route of infection is directly related to the chance of femoral head preservation and should, therefore, be the basis for decision-making. Only patients with blood-borne infections in an undamaged hip had a reasonable chance of femoral head preservation.
A total of 41 patients who underwent surgical treatment for septic arthritis (SA) of the native...