Severe acidosis due to 5-oxoprolinase inhibition by flucloxacillin in a patient with shoulder prosthesis joint infection

Lenz, Julia Elisabeth; Alt, Volker; Dienemann, Thomas

doi:https://doi.org/10.5194/jbji-7-71-2022

Articles | Volume 7, issue 2

https://doi.org/10.5194/jbji-7-71-2022

© Author(s) 2022. This work is distributed under
the Creative Commons Attribution 4.0 License.

https://doi.org/10.5194/jbji-7-71-2022

© Author(s) 2022. This work is distributed under
the Creative Commons Attribution 4.0 License.

Articles | Volume 7, issue 2

Case report

|

04 Apr 2022

Case report |

| 04 Apr 2022

Severe acidosis due to 5-oxoprolinase inhibition by flucloxacillin in a patient with shoulder prosthesis joint infection

Julia Elisabeth Lenz, Volker Alt, and Thomas Dienemann

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Cited articles

Adeva-Andany, M. M., Fernandez-Fernandez, C., Mourino-Bayolo, D., Castro-Quintela, E., and Dominguez-Montero, A.: Sodium bicarbonate therapy in patients with metabolic acidosis, Scientific World Journal, 2014, 627673, https://doi.org/10.1155/2014/627673, 2014.

Agrawal, A., Kishlyansky, M., Biso, S., Patnaik, S., and Punjabi, C.: Common, yet elusive: a case of severe anion gap acidosis, Oxf. Med. Case Reports, 2017, omx054, https://doi.org/10.1093/omcr/omx054, 2017.

Berbee, J. K., Lammers, L. A., Krediet, C. T. P., Fischer, J. C., and Kemper, E. M.: Metabolic acidosis caused by concomitant use of paracetamol (acetaminophen) and flucloxacillin? A case report and a retrospective study, Eur. J. Clin. Pharmacol., 73, 1459–1465, https://doi.org/10.1007/s00228-017-2311-6, 2017.

Emmett, M.: Acetaminophen toxicity and 5-oxoproline (pyroglutamic acid): a tale of two cycles, one an ATP-depleting futile cycle and the other a useful cycle, Clin. J. Am. Soc. Nephrol., 9, 191–200, https://doi.org/10.2215/CJN.07730713, 2014.

Hundemer, G. L. and Fenves, A. Z.: Acquired 5-oxoproline acidemia successfully treated with N-acetylcysteine, Proc (Bayl Univ Med Cent), 30, 169–170, https://doi.org/10.1080/08998280.2017.11929570, 2017.