Journal of Bone and Joint Infection
Journal of Bone and Joint Infection
JBJI
Articles | Volume 7, issue 2
Articles | Volume 7, issue 2
https://doi.org/10.5194/jbji-7-71-2022
© Author(s) 2022. This work is distributed under
the Creative Commons Attribution 4.0 License.
https://doi.org/10.5194/jbji-7-71-2022
© Author(s) 2022. This work is distributed under
the Creative Commons Attribution 4.0 License.
Articles | Volume 7, issue 2
Case report
 | 
04 Apr 2022
Case report |  | 04 Apr 2022

Severe acidosis due to 5-oxoprolinase inhibition by flucloxacillin in a patient with shoulder prosthesis joint infection

Julia Elisabeth Lenz, Volker Alt, and Thomas Dienemann

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Latest update: 26 Apr 2024
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Short summary
This case report is the first description of severe metabolic acidosis due to flucloxacillin therapy without relevant comedication that we know of. The described patient had been treated with flucloxacillin for 14 d due to intraoperative evidence of multisensitive Staphylococcus aureus due to periprosthetic shoulder infection. In patients on flucloxacillin therapy, acidosis should therefore always be considered as a differential diagnosis of tachypnoea or impaired mental status.
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