Locally delivered antistaphylococcal lysin exebacase or CF-296 is active in methicillin-resistant <i>Staphylococcus aureus</i> implant-associated osteomyelitis

Karau, Melissa; Schmidt-Malan, Suzannah; Mandrekar, Jay; Lehoux, Dario; Schuch, Raymond; Cassino, Cara; Patel, Robin

doi:https://doi.org/10.5194/jbji-7-169-2022

Articles | Volume 7, issue 4

https://doi.org/10.5194/jbji-7-169-2022

© Author(s) 2022. This work is distributed under
the Creative Commons Attribution 4.0 License.

https://doi.org/10.5194/jbji-7-169-2022

© Author(s) 2022. This work is distributed under
the Creative Commons Attribution 4.0 License.

Articles | Volume 7, issue 4

Original full-length article

|

27 Jul 2022

Original full-length article |

| 27 Jul 2022

Locally delivered antistaphylococcal lysin exebacase or CF-296 is active in methicillin-resistant Staphylococcus aureus implant-associated osteomyelitis

Melissa Karau, Suzannah Schmidt-Malan, Jay Mandrekar, Dario Lehoux, Raymond Schuch, Cara Cassino, and Robin Patel

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Cited articles

Alder, K. D., Lee, I., Munger, A. M., Kwon, H.-K., Morris, M. T., Cahill, S. V., Back, J., Kristin, E. Y., and Lee, F. Y.: Intracellular Staphylococcus aureus in bone and joint infections: A mechanism of disease recurrence, inflammation, and bone and cartilage destruction, Bone, 141, 115568, https://doi.org/10.1016/j.bone.2020.115568, 2020.

Asempa, T. E., Abdelraouf, K., Carabeo, T., Schuch, R., and Nicolau, D. P.: Synergistic activity of exebacase (CF-301) in addition to daptomycin against Staphylococcus aureus in a neutropenic murine thigh infection model, Antimicrob. Agents Chemother., 64, e02176–02119, 2019.

Chambers, H. F., Basuino, L., Diep, B., Steenbergen, J., Zhang, S., Tattevin, P., and Alder, J.: Relationship between susceptibility to daptomycin in vitro and activity in vivo in a rabbit model of aortic valve endocarditis, Antimicrob. Agents Chemother., 53, 1463–1467, 2009.

Clinicaltrials.gov: Direct lysis of Staph aureus resistant pathogen trial of exebacase (DISRUPT), NCT04160468, http://clinicaltrials.gov, last access: 24 September 2021.

Cobb, L. H., Park, J., Swanson, E. A., Beard, M. C., McCabe, E. M., Rourke, A. S., Seo, K. S., Olivier, A. K., and Priddy, L. B.: CRISPR-Cas9 modified bacteriophage for treatment of Staphylococcus aureus induced osteomyelitis and soft tissue infection, PLoS One, 14, e0220421, https://doi.org/10.1371/journal.pone.0220421, 2019.