Journal of Bone and Joint Infection
Journal of Bone and Joint Infection
JBJI
Articles | Volume 7, issue 4
Articles | Volume 7, issue 4
https://doi.org/10.5194/jbji-7-169-2022
© Author(s) 2022. This work is distributed under
the Creative Commons Attribution 4.0 License.
https://doi.org/10.5194/jbji-7-169-2022
© Author(s) 2022. This work is distributed under
the Creative Commons Attribution 4.0 License.
Articles | Volume 7, issue 4
Original full-length article
 | 
27 Jul 2022
Original full-length article |  | 27 Jul 2022

Locally delivered antistaphylococcal lysin exebacase or CF-296 is active in methicillin-resistant Staphylococcus aureus implant-associated osteomyelitis

Melissa Karau, Suzannah Schmidt-Malan, Jay Mandrekar, Dario Lehoux, Raymond Schuch, Cara Cassino, and Robin Patel

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Latest update: 23 Nov 2024
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Short summary
Orthopedic infections are complex, often requiring surgical intervention and prolonged antibiotic therapy, especially in the presence of a foreign body. In a rabbit model of implant-associated methicillin-resistant Staphylococcus aureus osteomyelitis, the lysins exebacase and CF-296 delivered locally with and without systemic daptomycin resulted in lower bacterial counts than those of control animals, showing a promising complement to conventional antibiotics in implant-associated infections.
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