Implant-related osteomyelitis is common in orthopedics. Absorbable antibiotic-loaded calcium sulfate (ACS) is an alternative to nonabsorbable antibiotic depot options for osteomyelitis and fracture-related infections. This study aims to evaluate intramedullary canal filling and coating characteristics of ACS around tibial nails using a tibia SAWBONES model. This research was done to better understand the potential utility of ACS in situations requiring fixation in the setting of local infection.

Osseointegration is a highly enabling reconstruction for patients with limb loss. However, infection can occur. There are currently poor diagnostic criteria for infection, and patients may be brought for surgery too much or too little. The study proposes an algorithm based on history, clinical, and laboratory data to predict the chance of culture-positive deep infection.