Articles | Volume 7, issue 3
https://doi.org/10.5194/jbji-7-117-2022
© Author(s) 2022. This work is distributed under
the Creative Commons Attribution 4.0 License.
the Creative Commons Attribution 4.0 License.
https://doi.org/10.5194/jbji-7-117-2022
© Author(s) 2022. This work is distributed under
the Creative Commons Attribution 4.0 License.
the Creative Commons Attribution 4.0 License.
Simulated large joint fluid model for evaluating intra-articular antibiotic delivery systems: initial evaluation using antibiotic-loaded calcium sulfate beads
Edward J. McPherson
Department of Orthopaedic Surgery, David Geffen School of Medicine at
UCLA, Santa Monica, 90404, USA
Jessica A. Jennings
Department of Biomedical Engineering, University of Memphis, Memphis,
38152, USA
Omar Yunis
Department of Biomedical Engineering, University of Memphis, Memphis,
38152, USA
Michael A. Harris
Department of Biomedical Engineering, University of Memphis, Memphis,
38152, USA
Matthew V. Dipane
CORRESPONDING AUTHOR
Department of Orthopaedic Surgery, David Geffen School of Medicine at
UCLA, Santa Monica, 90404, USA
Nora L. Curtin
Department of Orthopaedic Surgery, David Geffen School of Medicine at
UCLA, Santa Monica, 90404, USA
Madhav Chowdhry
Nuffield Department of Primary Care Health Sciences, Kellogg College,
University of Oxford, Oxford, OX1 2JD, UK
Andrew J. Wassef
Long Beach Lakewood Orthopedic Institute, Long Beach, 90808, USA
Joel D. Bumgardner
Department of Biomedical Engineering, University of Memphis, Memphis,
38152, USA
Scott P. Noel
Austin Medical Ventures, Germantown, 38138, USA
Related authors
Edward J. McPherson, Andrew J. Wassef, Matthew V. Dipane, and Madhav Chowdhry
J. Bone Joint Infect., 10, 309–315, https://doi.org/10.5194/jbji-10-309-2025, https://doi.org/10.5194/jbji-10-309-2025, 2025
Short summary
Short summary
We performed a mixing lab study describing 20 additional mixing formulas with mixing/set times in creating antimicrobial CaSO4 beads used for local delivery in periprosthetic joint infections, fracture-related infections, and other bone site infections. Most new formulas were focused on antifungal and antimycobacterial therapy. This information is to be utilized as an open-access reference for all physicians involved in the treatment of musculoskeletal infections.
Edward J. McPherson, Andrew J. Wassef, Matthew V. Dipane, and Madhav Chowdhry
J. Bone Joint Infect., 10, 309–315, https://doi.org/10.5194/jbji-10-309-2025, https://doi.org/10.5194/jbji-10-309-2025, 2025
Short summary
Short summary
We performed a mixing lab study describing 20 additional mixing formulas with mixing/set times in creating antimicrobial CaSO4 beads used for local delivery in periprosthetic joint infections, fracture-related infections, and other bone site infections. Most new formulas were focused on antifungal and antimycobacterial therapy. This information is to be utilized as an open-access reference for all physicians involved in the treatment of musculoskeletal infections.
Edward J. McPherson, Matthew V. Dipane, Madhav Chowdhry, and Andrew J. Wassef
J. Bone Joint Infect., 6, 405–412, https://doi.org/10.5194/jbji-6-405-2021, https://doi.org/10.5194/jbji-6-405-2021, 2021
Short summary
Short summary
The use of calcium sulfate as an antibiotic delivery vehicle is a growing treatment option used by surgeons in the face of infection following joint replacement surgery. Calcium sulfate can be mixed with antibiotics and formed into small beads, which can be delivered during surgery to the local site of infection. We performed a mixing study to formalize mixing methods for individual and combined antibiotics with a synthetic calcium sulfate product. We report our mixing formulas and set times.
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Short summary
A simulated large joint model has been established to help better understand the elution mechanics of antimicrobial agents and the devices used to deliver them to a large human joint. This model is unique to previously published models in that it more accurately represents the environment of a large human joint. The model was employed to evaluate four brands of commercial medical-grade calcium sulfate. These products were evaluated in both an unaltered state and when mixed with antibiotics.
A simulated large joint model has been established to help better understand the elution...