Simulated large joint fluid model for evaluating intra-articular antibiotic delivery systems: initial evaluation using antibiotic-loaded calcium sulfate beads

McPherson, Edward J.; Jennings, Jessica A.; Yunis, Omar; Harris, Michael A.; Dipane, Matthew V.; Curtin, Nora L.; Chowdhry, Madhav; Wassef, Andrew J.; Bumgardner, Joel D.; Noel, Scott P.

doi:https://doi.org/10.5194/jbji-7-117-2022

Articles | Volume 7, issue 3

https://doi.org/10.5194/jbji-7-117-2022

© Author(s) 2022. This work is distributed under
the Creative Commons Attribution 4.0 License.

https://doi.org/10.5194/jbji-7-117-2022

© Author(s) 2022. This work is distributed under
the Creative Commons Attribution 4.0 License.

Articles | Volume 7, issue 3

Original full-length article

|

17 May 2022

Original full-length article |

| 17 May 2022

Simulated large joint fluid model for evaluating intra-articular antibiotic delivery systems: initial evaluation using antibiotic-loaded calcium sulfate beads

Edward J. McPherson, Jessica A. Jennings, Omar Yunis, Michael A. Harris, Matthew V. Dipane, Nora L. Curtin, Madhav Chowdhry, Andrew J. Wassef, Joel D. Bumgardner, and Scott P. Noel

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Cited articles

Abosala, A. and Ali, M.: The Use of Calcium Sulphate beads in Periprosthetic Joint Infection, a systematic review, J. Bone Joint Infect., 5, 43–49, https://doi.org/10.7150/jbji.41743, 2020.

Aiken, S. S., Cooper, J. J., Florance, H., Robinson, M. T., and Michell, S.: Local Release of Antibiotics for Surgical Site Infection Management Using High-Purity Calcium Sulfate: An In Vitro Elution Study, Surg. Infect. (Larchmt.), 16, 54–61, https://doi.org/10.1089/sur.2013.162, 2015.

Andreacchio, A., Alberghina, F., Paonessa, M., Cravino, M., De Rosa, V., and Canavese, F.: Tobramycin-impregnated calcium sulfate pellets for the treatment of chronic osteomyelitis in children and adolescents, J. Pediatr. Orthop. B., 28, 189–195, https://doi.org/10.1097/BPB.0000000000000517, 2019.

Bortel, E. L., Charbonnier, B., and Heuberger, R.: Development of a Synthetic Synovial Fluid for Tribological Testing, Lubricants, 3, 664–686, https://doi.org/10.3390/lubricants3040664, 2015.

Bowyer, G. W. and Cumberland, N.: Antibiotic release from impregnated pellets and beads, J. Trauma, 36, 31–35, https://doi.org/10.1097/00005373-199403000-00008, 1994.