Articles | Volume 7, issue 3
Original full-length article
17 May 2022
Original full-length article |  | 17 May 2022

Simulated large joint fluid model for evaluating intra-articular antibiotic delivery systems: initial evaluation using antibiotic-loaded calcium sulfate beads

Edward J. McPherson, Jessica A. Jennings, Omar Yunis, Michael A. Harris, Matthew V. Dipane, Nora L. Curtin, Madhav Chowdhry, Andrew J. Wassef, Joel D. Bumgardner, and Scott P. Noel


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Short summary
A simulated large joint model has been established to help better understand the elution mechanics of antimicrobial agents and the devices used to deliver them to a large human joint. This model is unique to previously published models in that it more accurately represents the environment of a large human joint. The model was employed to evaluate four brands of commercial medical-grade calcium sulfate. These products were evaluated in both an unaltered state and when mixed with antibiotics.